Vitiligo pp 387-391 | Cite as

Empirical, Traditional, and Alternative Treatments

  • Mauro Picardo
  • Alain Taïeb


Trials have tested the use of alternative natural health products for the treatment of the vitiligo. Some prospective controlled, double-blind, and randomized studies have been performed. Traditional Chinese products and plant-derived photosensitizing agents have been proposed, and they are the most tested products.


Vitiligo Patient Melanocyte Proliferation Segmental Vitiligo Intracellular Signal Transduction Mechanism Decrease PGE2 Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Anbar TS, Westerhof W, Abdel-Rahman AT, Ewiss AA, El-Khayyat MA (2008). Effect of one session of ERG:YAG laser ablation plus topical 5Fluorouracil on the outcome of short-term NB-UVB phototherapy in the treatment of non-segmental vitiligo: a left-right comparative study. Photodermatol Photoimmunol Photomed 24:322–329PubMedCrossRefGoogle Scholar
  2. 2.
    Bedi KL, Zutshi U, Chopra CL et al (1989). Picrorhiza kur-roa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Etnopharmacol 27:347–352CrossRefGoogle Scholar
  3. 3.
    Durak I, Karayvaz M, Cimen MY, et al (2001). Aspirin impairs antioxidant system and causes peroxidation in human erythrocytes and guinea pig myocardial tissue. Hum Exp Toxicol 20:34–37PubMedCrossRefGoogle Scholar
  4. 4.
    Kapoor R, Phiske MM, Jerajani HR (2009). Evaluation of safety and efficacy of topical prostaglandin E2 in treatment of vitiligo. Br J Dermatol. 2009;160:861–3PubMedCrossRefGoogle Scholar
  5. 5.
    Khemis A, Ortonne JP (2004). Comparative study of vegetable extracts possessing active superoxide dismutase and catalase (Vitix) plus selective UVB phototherapy versus an excipient plus selective UVB phototherapy in the treatment of common vitiligo. Nouvelles Dermatologiques 23:45–46Google Scholar
  6. 6.
    Jeon S, Kim NH, Koo BS, et al (2007). Bee venom stimulates human melanocyte proliferation, melanogenesis, den-driticity and migration. Exp Mol Med 39:603–613PubMedCrossRefGoogle Scholar
  7. 7.
    Jin QX, Wj M, Zs D et al (1983). Clinical efficacy observation of combined treatment with chinese traditional medicine and western medicine for 407 cases of vitiligo. 12:9–11Google Scholar
  8. 8.
    Lin Z, Liao Y, Venkatasamy R, et al (2007). Amides from Piper nigrum L. with dissimilar effects on melanocytes proliferation in vitro. Pharm Pharmacol 59:529–536CrossRefGoogle Scholar
  9. 9.
    Liu ZJ, Xiang YP (2003). Clinical observation on treatment of vitiligo with xiaobai mixture. Chinese J Integr Trad Western Med 23:596–598Google Scholar
  10. 10.
    Mal'tsev VI, Kaliuzhnaia LD, Gubko LM (1995). Experience in introducing the method of placental therapy in vitiligo in Ukraine. Lik Sprava 7–8:123–125PubMedGoogle Scholar
  11. 11.
    Mallick S, Mandal SK, Bhadra R (2002). Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. J Biosci 27:243–249PubMedCrossRefGoogle Scholar
  12. 12.
    Namazi MR (2004). Statins: novel additions to the dermato-logic arsenal? Exp Dermatol 13:337–339PubMedCrossRefGoogle Scholar
  13. 13.
    Noel M, Gagné C, Bergeron J, et al (2004). Positive pleiotro-pic effects of HMG-CoA reductase inhibitor on vitiligo. Lip Health Dis 3:7–11CrossRefGoogle Scholar
  14. 14.
    Pal P, Mallick S, Mandal SK, et al (2002). A human placen-tal extract: in vivo and in vitro assessments of its melanocyte growth and pigment-inducing activities. Int J Dermatol 41:760–767PubMedCrossRefGoogle Scholar
  15. 15.
    Sethi S, Mahajan BB, Gupta RR, Ohri A (2007). Comparative evaluation of theraputic efficacy of dermoabrasion, der-moabrasion combined with topical 5% 5-fluorouracil cream, and dermoabrasion combined with topicalmplacentrex gel in localized stable vitiligo. Int J Dermatol 46:875–879PubMedCrossRefGoogle Scholar
  16. 16.
    Szczurko O, Boon HS (2008). A systematic review of natural health product treatment for vitiligo. BMC Dermatol 8:2–14PubMedCrossRefGoogle Scholar
  17. 17.
    Zailaie MZ (2004a). Short- and long-term effects of acetyl-salicylic acid treatment on the proliferation and lipid peroxidation of skin cultured melanocytes of active vitiligo. Saudi Med J 25:1656–1663PubMedGoogle Scholar
  18. 18.
    Zailaie MZ (2004b). The effect of acetylsalicylic acid on the release rates of leukotrienes B4 and C4 from cultured mel-anocytes of active vitiligo. Saudi Med J 25:1439–1444PubMedGoogle Scholar
  19. 19.
    Zailaie MZ (2005a). Aspirin reduces serum anti-melanocyte antibodies and soluble interleukin-2 receptors in vitiligo patients. Saudi Med J 26:1085–1091PubMedGoogle Scholar
  20. 20.
    Zailaie MZ (2005b). Decreased proinflammatory cytokine production by peripheral blood mononuclear cells from viti-ligo patients following aspirin treatment. Saudi Med J 26:799–805PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Mauro Picardo
    • Alain Taïeb

      There are no affiliations available

      Personalised recommendations