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Vitiligo pp 311-315 | Cite as

Editor’s Synthesis

  • Mauro PicardoEmail author
  • Alain Taïeb
Chapter

Core Messages

  • > Some mechanisms of melanocyte loss have been pooe In Viro

  • > Pathomechanisms should be envisioned within an enlarged dermal—epidermal melanin unit (including nerve endings)

  • > Melanocyte Stemnes, innate immunity Somatic Mosaicism (for SV), Membrane Lipids are newamas in the puzzle of utiligo pathophy-siology

Keywords

Atopic Dermatitis Somatic Mosaicism Hair Bulb NALP1 Inflammasome Mitf Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Cario-André M, Pain C, Gauthier Y et al (2006) In vivo and in vitro evidence of dermal fibroblasts influence on human epidermal pigmentation. Pigment Cell Res 19:434–442PubMedCrossRefGoogle Scholar
  2. 2.
    Fitzpatrick TB, Breathnach AS (1963) The epidermal melanin unit system. Dermatol Wochenschr 147:481–489PubMedGoogle Scholar
  3. 3.
    Gauthier Y (1995) The importance of Koebner's phenomenon in the induction of vitiligo vulgaris lesions. Eur J Dermatol 5:704–708Google Scholar
  4. 4.
    Hannun YA, Obeid LM (2008) Principles of bioactive lipid signalling:lessons from sphingolipids. Nat Rev Mol Cell Biol 9:139–150PubMedCrossRefGoogle Scholar
  5. 5.
    Happle R (2007) Superimposed segmental manifestation of polygenic skin disorders. J Am Acad Dermatol 57:690–699PubMedCrossRefGoogle Scholar
  6. 6.
    Jin Y, Mailloux CM, Gowan K et al (2007) NALP1 in viti-ligo-associated multiple autoimmune disease. N Engl J Med 356:1216–1225PubMedCrossRefGoogle Scholar
  7. 7.
    Le Poole IC, Das PK, van den Wijngaard RM et al (1993) Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 2:145–153PubMedCrossRefGoogle Scholar
  8. 8.
    Picardo M (2009) Lipid-mediated signalling and melanocyte function. Pigment Cell Mel Res 22:152–153CrossRefGoogle Scholar
  9. 9.
    Saha B, Singh SK, Mallik S et al (2009) Sphingolipid-mediated restoration of Mitf expression and repigmentation in vivo in a mouse model of hair graying. Pigment Cell Mel Res 22:205–218CrossRefGoogle Scholar
  10. 10.
    Strömberg S, Björklund MG, Asplund A et al (2008) Transcriptional profiling of melanocytes from patients with vitiligo vulgaris. Pigment Cell Melanoma Res 21:162–171PubMedCrossRefGoogle Scholar
  11. 11.
    Taieb A (1999) Hypothesis: from epidermal barrier dysfunction to atopic disorders. Contact Dermatitis 41:177–180PubMedCrossRefGoogle Scholar
  12. 12.
    Taieb A (2007) NALP1 and the inflammasomes: challenging our perception of vitiligo and vitiligo-related autoimmune disorders. Pigment Cell Res 20:260–262PubMedCrossRefGoogle Scholar
  13. 13.
    Taïeb A, Morice-Picard F, Jouary T et al (2008) Segmental vitiligo as the possible expression of cutaneous somatic mosaicism: implications for common non-segmental viti-ligo. Pigment Cell Melanoma Res 21:646–652PubMedCrossRefGoogle Scholar
  14. 14.
    Yonetani S, Moriyama M, Nishigori C et al (2008) In vitro expansion of immature melanoblasts and their ability to repopulate melanocyte stem cells in the hair follicle. J Invest Dermatol 128:408–420PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2010

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