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Vitiligo pp 25-32 | Cite as

Histopathology

  • Flávia Pretti AslanianEmail author
  • Absalom Filgueira
  • Tullia Cuzzi
  • Béatrice Vergier

Core Messages

  • › Adjacent, apparently normally pigmented skin should always be included to compare pig-mented and non-pigmented skin.

  • › It is important to indicate to the pathologist whether the lesion is stable or progressive.

  • › The main histological finding in vitiligo is a marked reduction or absence of pigmentation along the basal layer of the epidermis.

  • › Absence or loss of melanocytes in vitiligo leads to an absence of melanin resulting in depigmen-tation. Histochemistry (Fontana-Masson stain) and immunohistochemistry help to demonstrate pigment and cell loss.

  • › Associated inflammatory changes and/or pigmentary incontinence may or may not be present, in variable intensity, generally mild, and are noted at an early stage at the border of progressing lesions.

  • › Histopathology is needed to rule out other causes of acquired hypopigmentation, especially mycosis fungoides and leprosy.

Keywords

Basal Layer Mycosis Fungoides Outer Root Sheath Vitiligo Patient Active Vitiligo 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Flávia Pretti Aslanian
    • 1
    Email author
  • Absalom Filgueira
    • 2
  • Tullia Cuzzi
    • 3
  • Béatrice Vergier
    • 4
  1. 1.Federal University of Rio de JaneiroRio de JaneiroBrasil
  2. 2.Department of DermatologyFederal University of Rio de JaneiroLeblonBrasil
  3. 3.Federal University of Rio de JaneiroRio de JaneiroBrasil
  4. 4.Department of PathologyHôpital du Haut Lév®queBordeauxFrance

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