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Anatomical Imaging and Post-Genomic Biology

  • Benedikt Hallgrímsson
  • Nicholas Jones

Abstract

Anatomical imaging provides the morphological context for post-genomic biology. Volumetric imaging is central to the creation of atlases of gene expression as well as the visualization of increasingly complex molecular information in a spa-tiotemporal context. To become integrated into the types of hypotheses that systems biology and other post-genomic approaches generate, however, anatomical imaging must evolve further. Modes of phenotypic analyses must begin to generate databases and data repositories that will support data-mining approaches to increasingly complex and broad biological questions. For this to happen there must be increasing emphasis on high-throughput phenotypic analysis, data standardization, data sharing, and the systematic quantification of phenotypic variation. The solutions to these issues will lay the foundations for a new field of study, that of phenogenomics.

Keywords

Phenotypic Analysis Microcomputed Tomography Compute Microtomography Volumetric Dataset Optical Projection Tomography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Benedikt Hallgrímsson
    • 1
  • Nicholas Jones
    • 1
  1. 1.Department of Cell Biology and Anatomy and the McCaig Bone and Joint InstituteUniversity of Calgary, Faculty of MedicineCalgaryCanada

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