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cGMP: Generators, Effectors and Therapeutic Implications pp 409–421Cite as

cGMP-Dependent Protein Kinase Modulators

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 191))

Abstract

The first cGMP-dependent protein kinase (PKG) modulators were described nearly 30 years ago and since then more than 200 compounds have been synthesized and tested, but only a small subset of these compounds has found widespread application. The aim of this review is to suggest a framework for evaluating and using PKG activators and inhibitors and to explore and interpret PKG signal transduction in cell culture-based model systems. Therefore, cross-reactivity of cGMP-analogs with other classes of cyclic nucleotide binding proteins, as well as the advantages and problems of newly designed PKG inhibitors, are discussed.

Additional information and a search option are available at www.cyclic-nucleotides.org.

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Authors and Affiliations

  1. Institute of Clinical Biochemistry, University of Wuerzburg, Grombuehlstrasse 12, Wuerzburg, 97080, Germany

    Elke Butt

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  1. Elke Butt
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Editors and Affiliations

  1. Dept. Pharmacology, Monash University, Wellington Road, Clayton, VIC, 3800, Australia

    Harald H. H. W. Schmidt

  2. Inst. Pharmakologie und Toxikologie, TU München, Biedersteiner Str. 29, München, 80802, Germany

    Franz Hofmann

  3. Bayer Schering Pharma AG Cardiology Research, Pharma Research Center, Wuppertal, 42096, Germany

    Johannes-Peter Stasch

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Butt, E. (2009). cGMP-Dependent Protein Kinase Modulators. In: Schmidt, H.H.H.W., Hofmann, F., Stasch, JP. (eds) cGMP: Generators, Effectors and Therapeutic Implications. Handbook of Experimental Pharmacology, vol 191. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68964-5_17

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