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African Swine Fever Virus

  • Chapter
Lesser Known Large dsDNA Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 328))

African swine fever virus (ASFV) is a large, intracytoplasmically-replicating DNA arbovirus and the sole member of the family Asfarviridae. It is the etiologic agent of a highly lethal hemorrhagic disease of domestic swine and therefore extensively studied to elucidate the structures, genes, and mechanisms affecting viral replication in the host, virus—host interactions, and viral virulence. Increasingly apparent is the complexity with which ASFV replicates and interacts with the host cell during infection. ASFV encodes novel genes involved in host immune response modulation, viral virulence for domestic swine, and in the ability of ASFV to replicate and spread in its tick vector. The unique nature of ASFV has contributed to a broader understanding of DNA virus/host interactions.

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Authors and Affiliations

  1. Department of Pathobiology and Veterinary Science, and Center of Excellence for Vaccine Research, University of Connecticut, Storrs, CT, 06269, USA

    E. R. Tulman

  2. Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, 61802, USA

    G. A. Delhon

  3. National Veterinary Research and Quarantine Service, Anyang Kyonggido, 430-016, Korea

    B. K. Ku

  4. Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, 61802, USA

    D. L. Rock

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  1. Department of Plant Pathology and Nebraska Center for Virology, University of Nebraska, Lincoln, NE, 68583-0722, USA

    James L. Van Etten

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Tulman, E.R., Delhon, G.A., Ku, B.K., Rock, D.L. (2009). African Swine Fever Virus. In: Van Etten, J.L. (eds) Lesser Known Large dsDNA Viruses. Current Topics in Microbiology and Immunology, vol 328. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68618-7_2

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