Abstract
Osteoporosis is the most common metabolic bone disease. It is characterised by reduced bone mass, altered bone architecture and the clinical consequence of fracture with little or no trauma (low-trauma fractures, insufficiency fractures). These fractures tend to occur most commonly in sites of the skeleton that are rich in trabecular bone: the wrist, spine and hip. It is the last of these which has the greatest morbidity and mortality, but all osteoporotic fractures result in pain and suffering for patients and have considerable socio-economic impact on health care systems and society generally (Cooper 1996). 1 in 2 women and 1 in 5 men over the age of 50 years will suffer a fracture in their lifetime in the Western world (van Staa et al. 2001). In the past 20 years there have been significant advances in knowledge of the epidemiology, patho-physiology, and treatment of osteoporosis (Sambrook and Cooper 2006). These therapies increase bone mineral density (BMD) by between 5–12% and, more importantly, reduce future fracture risk to a greater magnitude (decrements between 30–70%) (Royal College of Physicians 1999, 2000; Meunier 2001; Compston 2005; Poole and Compston 2006; Keen 2007).
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References
Adams JE (1998) Single-and dual-energy X-ray absorptiometry. In: Genant HK, Guglielmi G, Jergas M (eds) Bone densitometry and osteoporosis. Springer, Berlin Heidelberg New York, p 305–334
Adams JE (2008) Metabolic and endocrine skeletal disease. In: Grainger & Allison’s Diagnostic Radiology, 5th Edition. Vol 2, Sect 5 Musculoskeletal Chap 49. Churchill Livingstone Elsevier, Philadelphia, p 1083–1113
Ahmed AIH, Blake GM, Rymer JM, Fogelman I (1997) Screening for osteoporosis and osteopenia: do the accepted normal ranges lead to overdiagnosis? Osteoporos Int 7:432–438
Bachrach LK (2005) Assessing bone health in children: who to test and what does it mean? Pediatr Endocrinol Rev 2(S3):332–336
Beck TJ (2007) Extending DXA beyond bone mineral density: understanding hip structure analysis. Curr Osteoporos Rep 5:49–55
Blake GM, Fogelman I (1997) Technical principles of dual energy X-ray absorptiometry. Semin Nucl Med 27:210–228
Blake GM, Fogelman I (2007a) The role of DXA bone density scans in the diagnosis and treatment of osteoporosis. Postgrad Med J 83:509–517
Blake GM, Fogelman I (2007b) The correction of BMD measurements for bone strontium content. J Clin Densitom 10:259–265
Blake GM, Wahner HW, Fogelman I (1999) The evaluation of osteoporosis: dual energy X-ray absorptiometry and ultrasound in clinical practice. Martin Dunitz, London
Blake GM, Chinn DJ, Steel SA, Patel R, Panayiotou E, Thorpe J, Fordham JN, National Osteoporosis Society Bone Denstiometry Forum (2005) A list of device-specific thresholds for the clinical interpretation of peripheral X-ray absorptiometry examinations. Osteoporos Int 16:2149–2156
Blake GM, Knapp KM, Spector TD, Fogelman I (2006a) Predicting the risk of fracture at any skeletal site: are all bone mineral density measurement sites equally effective? Calcif Tiss Int 78:9–17
Blake GM, Naeem M, Boutros M (2006b) Comparison of effective dose to children and adults from dual energy X-ray absorptiometry examinations. Bone 38:935–942
Borgstrom F, Johnell O, Kanis JA, Jonsonn B, Rehnberg C (2006) At what hip fracture risk is it cost-effective to treat? International intervention thresholds for the treatment of osteoporosis. Osteoporos Int 17:1459–1471
Bouxsein ML, Parker RA, Greenspan SL (1999) Forearm bone mineral densitometry cannot be used to monitor response to alendronate. Osteoporos Int 10:505–509
Brennan BM, Mughal Z, Roberts SA, Ward K, Shalet SM, Eden TO, Will AM, Stevens RF, Adams JE (2005) Bone mineral density in childhood survivors of acute lymphoblastic leukaemia treated without cranial irradiation. J Clin Endocrinol Metab 90:689–694
Cameron JR, Sorenson J (1963) Measurement of bone mineral density in vivo: an improved method. Science 142:230–232
Carter DR, Bouxsein ML, Marcus R (1992) New approaches for interpreting projected bone densitometry data. J Bone Miner Res 7:137–145
Cheng S, Suominen H, Sakari-Rantala R, Laukkanen P, Avikainen V, Heikkinen E (1997) Calcaneal bone mineral density predicts fracture occurrence: a five-year follow-up study in elderly people. J Bone Miner Res 12:1075–1082
Compston J (2005) Guidelines for the management of osteoporosis: the present and the future. Osteoporos Int 16:1173–1176
Compston JE, Cooper C, Kanis JA (1995) Bone densitometry in clinical practice. Br Med J 310:1507–1510
Cooper C (1996) Epidemiology and definition of osteoporosis. In: Compston JE (ed) Osteoporosis: new perspectives on causes, prevention and treatment. Royal College of Physicians of London p 1–10
Crabtree NJ, Kibirige MS, Fordham J, Banks LM, Muntoni F, Chinn D, Boivin CM, Shaw NJ (2004) The relationship between lean body mass and bone mineral content in paediatric health and disease. Bone 35:965–972
Cullum ID, Ell PJ, Ryder JP (1989) X-ray dual photon absorptiometry: a new method for the measurement of bone density. Brit J Radiol 62:587–592
de Laet CE, Van Hout BA, Burger H, Weel AE, Hofman A, Pols HA (1998) Hip fracture prediction in elderly men and women: validation in the Rotterdam study. J Bone Miner Res 13:1587–1593
Del Rio L, Pons F, Huguet M, Setoain FJ (1995) Anteroposterior versus lateral bone mineral density of spine assessed by dual X-ray absorptiometry. Eur J Radiol 22:407–412
Drage NA, Palmer RM, Blake GM, Wilson R, Crane F, Fogelman I (2007) A comparison of bone mineral density in the spine, hip and jaw of edentulous subjects. Clin Oral Implants Res 18:496–500
Dunn WL, Wahner HW, Riggs BL (1980) Measurement of bone mineral content in human vertebrae and hip by dual photon absorptiometry. Radiology 136:485–487
Eastell R, Wahner HW, O’Fallon WM, Amadio PC, Melton LJ 3rd, Riggs BL (1989). Unequal decrease in bone density of the lumbar spine and ultradistal radius in Colles’ and vertebral fracture syndromes. J Clin Invest 83:168–174
Engelke K, Gluer CC (2006) Quality and performance measures in bone densitometry: part 1: errors and diagnosis. Osteoporos Int 17:1283–1292
Engelke K, Gluer CC (2006) Quality and performance measures in bone densitometry: part 2: fracture risk. Osteoporos Int 17:1449–1458
Eiken P, Kolthoff N, Barenholdt O, Hermansen F, Pors Nielsen S (1994) Switching from pencil-beam to fanbeam. II. Studies in vivo. Bone 15:671–676
European Communities/ European Foundation for Osteoporosis (1998) Building strong bones and preventing fractures. Summary report on osteoporosis in the European Community — action for prevention. European Communities/European Foundation for Osteoporosis, Germany, p 3–12
Faulkner KG, McClung MR (1995) Quality control of DXA instruments in multicenter trials. Osteoporos Int 5:218–227
Faulkner KG, Gluer CC, Majumdar S, Lang P, Engelke K, Genant HK (1991) Non-invasive measurements of bone mass, structure and strength: current methods and experimental techniques. Am J Radiol 157:1229–1237
Faulkner RA, Bailey DA, Drinkwater DT, Wilkinson AA, Houston CS, McKay HA (1993) Regional and total body bone mineral content, bone mineral density, and total body tissue composition in children 8–16 years of age. Calcif Tissue Int 53:7–12
Faulkner KG, McClung M, Cummings SR (1994) Automated evaluation of hip axis length for predicting hip fracture. J Bone Miner Res 9:1065–1070
Faulkner KG, von Stetten E, Miller P (1999) Discordance in patient classification using T-score. J Clin Densitom 2:343–350
Ferrar L, Jiang G, Eastell R, Peel NF (2003) Visual identification of vertebral fractures in osteoporosis using morphometric X-ray absorptiometry. J Bone Miner Res 18:933–938
Ferrar L, Jiang G, Adams J, Eastell R (2005) Identification of vertebral fractures: an update. Osteoporos Int 16:717–728
Fewtrell MS; British Paediatric and Adolescent Bone Group (2003) Bone densitometry in children assessed by dual X-ray absorptiometry: uses and pitfalls. Arch Dis Child 88:795–798
Fogelman I, Blake GM (2005) Bone densitometry: an update. Lancet 366(9503):2068–2070
Franck H, Munz M, Scherrer M (1995) Evaluation of dualenergy X-ray absorptiometry bone mineral measurement — comparison of a single-beam and fan beam design: the effect of osteophytic calcification on spine bone mineral density. Calcif Tissue Int 56:192–195
Frohn J, Wilken T, Falk S, Strutte HJ, Kollath J, Hor G (1991) Effect of aortic sclerosis on bone mineral measurements by dual-photon absorptimetry. J Nucl Med 32:259–262
Genant HK, Grampp S, Glueer CC, Faulkner KG, Jergas M, Engelke K, Hagiwara S, van Kuijk C (1994) Universal standardisation for the dual X-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res 9:1503–1514
Genant HK, Engelke K, Fuerst T, Gluer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M (1996) Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res 11:707–730
Genant HK, Li Y, Wu CY, Shepherd JA (2000) Vertebral fractures in osteoporosis: a new method for clinical assessment. J Clin Densitom 3:281–290
Gilsanz V (1998) Bone density in children: a review of the available techniques and indications. Eur J Radiol 26:177–182
Gluer CC (1999) Monitoring skeletal changes by radiological techniques. J Bone Miner Res 14:1952–1962
Gluer CC, Blake G, Blunt BA, Jergas M, Genant HK (1995) Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int 5:262–270
Goh JC, Low SL, Bose K (1995) Effect of femoral rotation on bone mineral density measurements with dual energy Xray absorptiometry. Calcif Tissue Int 57:340–343
Grampp S, Jergas M, Gluer CC, Lang P, Brastow P, Genant HK (1993) Radiologic diagnosis of osteoporosis: current methods and perspectives. Radiol Clin North Am 31(5):1131–1145
Grampp S, Genant HK, Mathur A, Lang P, Jergas M, Takada M, Gluer CC, Lu Y, Chavez M (1997) Comparisons of non-invasive bone mineral measurements in assessing age-related loss, fracture discrimination and diagnostic classification. J Bone Miner Res 12:697–711
Gregory JS, Testi D, Stewart A, Undrill PE, Reid DM, Aspden RM (2004) A method of assessment of the shape of the proximal femur and its relationship to osteoporotic hip fracture. Osteoporos Int 15:5–11
Gregory JS, Stewart A, Undrill PE, Reid DM, Aspden RM (2005) Bone shape, structure and density as determinants of osteoporotic hip fracture: a pilot study investigating the combination of risk fracture. Invest Radiol 40:591–597
Griffin MC, Kimble R, Hopfer W, Pacifici R (1993) Dualenergy X-ray absorptiometry of the rat: accuracy, precision and measurement of bone loss. J Bone Miner Res 8:795–800
Griffiths MR, Noakes KA, Pocock NA (1997) Correcting the magnification error of fan beam densitometers. J Bone Miner Res 12:119–123
Guglielmi G, Grimston SK, Fischer KC, Pacifici R (1994) Osteoporosis: diagnosis with lateral and posteroanterior dual X-ray absorptiometry compared with quantitative CT. Radiology 192:845–850
Harrison EJ, Adams JE (2006) Application of a triage approach to peripheral bone densitometry reduces requirement for central DXA, but is not cost effective. Calc Tiss Int 79:199–206
Haugeberg G, Emery P (2005) Value of dual-energy X-ray absorptiometry as a diagnostic tool in early rheumatoid arthritis. Rheum Dis Clin North Am 31:715–728
Holmes SJ, Economou G, Whitehouse RW, Adams JE, Shalet SM (1994) Reduced bone mineral density in patients with adult onset growth hormone deficiency. J Clin Endocrinol Metab 78:669–674
Hogler W, Briody J, Woodhead HJ, Chan A, Cowell CT (2003) Importance of lean mass in the interpretation of total body densitometry in children and adolescents. J Pediatr 143:81–88
Horner K, Devlin H, Alsop CW, Hodgkinson IM, Adams JE (1996) Mandibular bone mineral density as a predictor of skeletal osteoporosis. Br J Radiol 69:1019–1025
Huda W, Morin RL (1996) Patient doses in bone densitometry Br J Radiol 69:422–425
Hui SL, Gao S, Zhou XH, Johston CC Jr, Lu Y, Gluer CC, Grampp S, Genant HK (1997) Universal standardization of bone density measurements: a method with optimal properties for calibration among several instruments. J Bone Miner Res 12:1463–1470
International Society for Clinical Densitometry (2005) 342 North Main Street, West Hartford CT06117-2507 USA; www.ISCD.org
Jaovisidha S, Sartoris DJ, Martin EM, De Maeseneer M, Szollar SM, Deftos LJ (1997) Influence of spondylopathy on bone densitometry using dual energy X-ray absorptiometry. Calcif Tissue Int 60:424–429
Jergas M, Breitenseher M, Gluer CC, Black D, Lang P Grampp s, Engelke K, Genant HK (1995) Which vertebrae should be assessed using lateral dual-energy X-ray absorptiometry of the lumbar spine. Osteoporos Int 5:196–204
Kalender WA (1992) Effective dose values in bone mineral measurements by photon absorptiometry and computed tomography. Osteoporos Int 2:82–87
Kalender WA, Felsenberg D, Genant HK, Dequeker J, Reeve J (1995) The European Spine Phantom: a tool for standardization and quality control in spinal bone mineral measurement by DXA and QCT. Eur J Radiol 20:83–92
Kanis JA (2002) Diagnosis of osteoporosis and assessment of fracture risk. Lancet 359(9321):1929–1936
Kanis JA, Delmas P, Burckhardt P, Cooper C, Torgerson D (1997) Guidelines for diagnosis and management of osteoporosis: EFFO report. Osteoporos Int 7:390–406
Kanis JA, Gluer C, for the Committee of the Scientific Advisors, International Osteoporosis Foundation (2000) An update in the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11:192–202
Kanis JA, Johnell O, Oden A, Johansson H, Eisman JA, Fujiwara S, Kroger H, Honkanen R, Melton LJ Jr, O’Neill T, Reeve J, Silman A, Tenenhouse A (2006) The use of multiple sites for the diagnosis of osteoporosis. Osteoporos Int 17:527–534
Kastl S, Sommer T, Klein P, Hohenberger W, Engelke K (2002) Accuracy and precision oof bone mineral density and bone mineral content in the excised rat humeri using fan beam dual-energy X-ray absorptiometry. Bone 30:243–246
Katzman DK, Bachrach LK, Carter DR, Marcus R (1991) Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metab 73:1332–1339
Kelly TL, Slovik DM, Schoenfeld DA, Neer RM (1988) Quantitative digital radiography versus dual photon absorptiometry of the lumbar spine. J Clin Endocrinol Metab 67:839–844
Keen R (2007) Osteoporosis: strategies for prevention and management. Best Pract Res Clin Rheumatol 21:109–122
Kim J, Shen W, Gallagher D, Jones A Jr, Wang Z, Wang J, Heshka S, Heymsfield SB (2006) Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents Am J Nutr 84:1014–1020
Koo WW, Hockman EM, Hammami M (2004) Dual energy X-ray absorptiometry measurements in small subjects: conditions affecting clinical measurements. J Am Coll Nutr 23:212–219
Kroger H, Kotaniemi A, Vainio P, Alhava E (1992) Bone densitometry of the spine and femur in children by dual-energy X-ray absorptiometry. Bone Miner 17:75–85
Kroger H, Huopio J, Honkanen R, Tuppurainen M, Puntila E, Alhava E, Saarikoski S (1995) Prediction of fracture risk using axial bone mineral density in a perimenopausal population: a prospective study. J Bone Miner Res 10:302–306
Laskey MA, Crisp AJ, Compston JE, Khaw KT (1993) Heterogeneity of spine bone density. Br J Radiol 66:480–483
Lewis MK, Blake GM (1995) Patient dose in morphometric X-ray absorptiometry Osteoporos Int 5:281–282
Lewis MK, Blake GM, Fogelman I (1994) Patient doses in dual X-ray absorptiometry. Osteoporos Int 4:11–15
Link TM, Guglielmi G, van Kuijk C, Adams JE (2005) Radiologic assessment of osteoporotic fracture: diagnostic and prognostic implications. Eur Radiol 15:1521–1532
Lu PW, Cowell CT, Lloyd-Jones SA, Briody J, Howman-Giles R (1996) Volumetric bone mineral density in normal subjects, aged 5–27 years. J Clin Endocrinol Metab; 81:1586–1590
Looker AC, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP, Johnston CC Jr, Lindsay R (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468–489
Lu PW, Cowell CT, Lloyd-Jones SA, Briody JN, Howman-Giles R (1996) Volumetric bone mineral density in normal subjects, aged 5-27 years. J Clin Endocrinol Metab 81:1586–1590
Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone density predict occurrence of osteoporotic fractures. Br Med J 312:1254–1259
Melton LJ, Eddy DM, Johnson CC (1990) Screening for osteoporosis. Ann Intern Med 112:516–528
Melton LJ 3rd, Atkinson EJ, O’Fallon WM, Wahner HW, Riggs BL (1993) Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 8:1227–1233
Meunier PJ (2001) Anabolic agents for treatment of postmenopausal osteoporosis. J Bone Spine 68:576–581
Miller P (2000) Controversies in bone mineral density diagnostic classification. Calcif Tissue Int 66:317–319
Miller P, Bonnick SL Rosen CJ (1996) Consensus of an international panel on the clinical utility of bone mass measurements in the detection of low bone mass in the adult population. Calcif Tissue Int 58:207–214
Mølgaard C, Thomsen BL, Prentice A, Cole TJ, Michaelsen KF (1997) Whole body bone mineral content in healthy children and adolescents. Arch Dis Child 76:9–15
National Osteoporosis Society (2001) Position statement on the use of peripheral X-ray absorptiometry in the management of osteoporosis. National Osteoporosis Society, Camerton, Bath, UK, p 1–15
National Osteoporosis Society (2004) A practical guide to bone densitometry in children. National Osteoporosis Society, Camerton, bath, BA2 0PJ, UK
Njeh CF, Apple K, Temperton DH, Boivin CM (1996) Radiological assessment of a new bone densitometer: the Lunar expert. Br J Radiol 69:335–340
Nord RH (1992) Work in progress: a cross-calibration study of four DXA instruments designed to culminate in inter-manufacturer standardization. Osteoporos Int 2:210–211
Orwoll ES, Oviatt SK, Mann T (1990) The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men. J Clin Endocrinol Metab 70:1202–1207
Pacheco EM, Harrison EJ, Ward KA, Lunt M, Adams JE (2002) Detection of osteoporosis by dual energy X-ray absorptiometry (DXA) of the calcaneus: is the WHO criterion applicable? Calcif Tissue Int 70:475–482
Parfitt AM (1990) Interpretation of bone densitometry measurements: disadvantages of a percentage scale and a discussion of some alternatives. J Bone Miner Res 5:537–540
Patel R, Blake GM, Herd RJM, Fogelman I (1997) The effect of weight change on DXA scans in a 2 year prospective clinical trial of cyclical etidronate therapy. Calcif Tissue Int 61:393–399
Patel R, Blake GM, Fogelman I (2004) An evaluation of the United Kingdom Osteoporosis Society position statement on the use of peripheral dual-energy X-ray absorptiometry. Osteoporos Int 15:497–504
Peel N, Eastell R (1993) Measurement of bone mass and turnover. Baillieres Clin Rheumatol 7:479–498
Peel N, Johnson A, Barrington NA, Smith TW, Eastell R (1993) Impact of anomalous vertebral segmentation on the measurements of bone mineral density. J Bone Miner Res 8:719–723
Poole KE, Compston JE (2006) Osteoporosis and its management. BMJ 333(7581):1251–1256
Pietrobelli A, Formica C, Wang Z, Heymsfield SB (1996) Dual-energy X-ray absorptiometry body composition model: review of physical concepts. Am J Physiol 271(6 Pt 1) E941–951
Prentice A, Parsons TJ, Cole TJ (1994) Uncritical use of bone mineral density in absorptiometry may lead to sizerelated artifacts in the identification of bone mineral determinants. Am J Clin Nutr; 60:837–842
Prince RL (2007) Calcium and vitamin D — for whom and when. Menopause Int 13:35–37
Quek ST, Peh WC (2002) Radiology of osteoporosis. Semin Musculoskelet Radiol 6:197–206
Rea JA, Steiger P, Blake GM, Fogelman I (1998) Optimizing data acquisition and analysis of morphometric X-ray absorptiometry. Osteoporos Int 8:177–183
Rea JA, Li J, Blake GM, Steiger P, Genant HK, Fogelman I (2000) Visual assessment of vertebral deformity by X-ray absorptiometry: a highly predictive method to exclude vertebral deformity. Osteoporos Int 11:660–668
Rea JA, Chen MB, Li J, Marsh E, Fan B, Blake GM, Steiger P, Smith IG, Genant HK, Fogelman I (2001) Vertebral morphometry: a comparison of long-term precision of morphometric X-ray absorptiometry and morphometric radiography in normal and osteoporotic subjects. Osteoporos Int 12:158–166
Roberts MG, Cootes TF, Pacheco EM, Adams JE (2007) Quantitative fracture detection on Dual Energy X-ray Absorptiometry (DXA) images using shape and appearance models. Acad Radiol 14:1166–1178
Royal College of Physicians (1999) Osteoporosis: guidelines for prevention and treatment. Royal College of Physicians, London, UK, p 63–70
Royal College of Physicians (2000) Osteoporosis: clinical guidelines for prevention and treatment. Update on pharmacological interventions and an algorithm for management. Royal College of Physicians, London, UK, pp 1–16
Salle BL, Braillon P, Glorieux FH, Brunet J, Cavero E, Meunier PJ (1992) Lumbar bone mineral content measured by dual energy X-ray absorptiometry in newborns and infants. Acta Paediatr 81:953–958
Sambrook P, Cooper C (2006) Osteoporosis. Lancet 367(9527):2010–2018
Sawyer AJ, Bachrach LK, Fung EB (Eds) (2006) Bone densitometry in growing patients; guidelines for clinical practice. Humana Press http://www.humanapress.com
Sanchez MM, Gilsanz V (2005) Pediatric DXA measurements Pediatr Endocrinol Rev 2Suppl 3:337–341
Schott AM, Cormier C, Hans D, Favier F, Hausherr E, Dargent-Molina P, Delmas PD, Ribot C, Sebert JL, Breart G, Meunier PJ (1998) How hip and whole-body bone mineral density predict hip fracture in elderly women: the EPIDOS Prospective Study. Osteoporos Int 8:247–254
Sievanen H, Oja P, Vuori I (1992) Precision of dual energy x-ray absorptiometry in determining bone mineral density and content of various skeletal sites. J Nucl Med 33:1137–1142
Smyth PP, Taylor CJ, Adams JE (1999) Vertebral shape: automatic measurement with active shape models. Radiology 211:571–578
Soininvaara T, Kroger H, Jurvelin JS, Miettinen H, Suomalainen O, Alhava E (2000) Measurement of bone density around total knee arthroplasty using fan-beam dual energy X-ray absorptiometry. Calcif Tissue Int 67:267–272
Tothill P, Hannan WJ (2000) Comparison between Hologic QDR 1000 W, QDR 4500A, and Lunar Expert dual-energy X-ray absorptiometry scanners for measuring total bone and soft tissues. Ann N Y Acad Sci 904:63–71
van Rijn RR, van der Sluis IM, Link TM, Grampp S, Guglielmi G, Imhof H, Glüer C, Adams JE, van Kuijk C (2003) Bone densitometry in children: a critical appraisal. Eur Radiol 13:700–710
van Staa TP, Dennison EM, Leufkens HG, Cooper C (2001) Epidemiology of fractures in England and Wales. Bone 29:517–522
Vokes T, Bachman D, Baim S, Binkley N, Broy S, Ferrar L, Lewiecki EM, Richmand B, Schousboe J; International Society of Clinical Densitometry (2006) Vertebral fracture assessment: the 2005 ISCD Official Positions. J Clin Densitom 9:37–46
Ward KA, Mughal Z, Adams JE (2006) Tools for measuring bone in children and adolescents. In: Bone densitometry in growing patients; guidelines for clinical practice. Editors: Sawyer AJ, Bachrach LK, Fung EB Humana Press http://www.humanapress.com pp 15–40
Ward KA, Ashby RL, Roberts SA, Adams JE, Mughal MZ (2007) UK reference data for the Hologic QDR Discovery dual energy X-ray absorptiometry scanner in healthy children aged 6-17 years. Arch Dis Child 92:53–59
Warner JT, Cowan FJ, Dunstan FD, Evand WD, Webb DK, Gregory JW (1998) Measured and predicted bone mineral content in healthy boys and girls aged 6–18 years: adjustment for body size and puberty. Acta Paediatr 87:244–249
Wilkinson JM, Peel NF, Elson RA, Stockley I, Eastell R (2001) Measuring bone mineral density of the pelvis and proximal femur after total hip arthroplasty. J Bone Joint Surg Br 83:283–288
Wilson CR, Fogelman I, Blake GM, Rodin A (1991) The effect of positioning on dual-energy X-ray absorptiometry of the proximal femur. Bone Miner 13:69–76
Wishart J, Horowitz M, Need A, Nordin BE (1990) Relationship between forearm and vertebral mineral density in postmenopausal women with primary hyperparathyroidism. Arch Intern Med 150:1329–1331
World Health Organisation Study Group (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organisation, Geneva, Switzerland (WHO Technical Report Series 843)
Young JT, Carter K, Marion MS, Greendale GA (2000) A simple method of computing hip axis length using fan-beam densitometry and anthropomorphic measurements. J Clin Densitom 3:325–331
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Adams, J.E. (2008). Dual-Energy X-Ray Absorptiometry. In: Grampp, S. (eds) Radiology of Osteoporosis. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68604-0_7
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