Abstract
Among the palliative therapy regimens of hepatocellular carcinoma (HCC), the intra-arterial application of iodine-131-lipiodol (131I-lipiodol) has been established, particularly in Asia and in French-speaking Europe (Lambert and Van de Wiele 2005). Lipiodol (Laboratoire Guerbet, France) is a poppy seed oil containing 38% iodine by weight. It was first used as an X-ray contrast medium for hepatic angiography and has been shown to be cleared less rapidly from HCC cells than normal liver tissue, when injected into the hepatic artery (Nakakuma et al. 1985; Okayasu et al. 1988).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Al-Mufti RA, Pedley RB, Marshall D et al (1999) In vitro assessment of Lipiodol-targeted radiotherapy for liver and colorectal cancer cell lines. Br J Cancer 79:1665–1671
Anonymous (2003) Guidelines for 131I-ethiodised oil (Lipiodol) therapy [No authors listed]. Eur J Nucl Med Mol Imaging 30:BP20–BP22
Bhattacharya S, Dhillon AP, Winslet MC et al (1996) Human liver cancer cells and endothelial cells incorporate iodised oil. Br J Cancer 73:877–881
Lambert B, Van de Wiele C (2005) Treatment of hepatocellular carcinoma by means of radiopharmaceuticals. Eur J Nucl Med Mol Imaging 32:980–989
Leung WT, Lau WY, Ho S et al (1994) Selective internal radiation therapy with intra-arterial iodine-131-Lipiodol in inoperable hepatocellular carcinoma. J Nucl Med 35:1313–1318
Monsieurs MA, Bacher K, Brans B et al (2003) Patient dosimetry for 131I-lipiodol therapy. Eur J Nucl Med Mol Imaging 30:554–561
Nakakuma K, Tashiro S, Hiraoka T et al (1985) Hepatocellular carcinoma and metastatic cancer detected by iodized oil. Radiology 154:15–17
Okayasu I, Hatakeyama S, Yoshida T et al (1988) Selective and persistent deposition and gradual drainage of iodized oil, lipiodol in the hepatocellular carcinoma after injection into the feeding hepatic artery. Am J Clin Pathol 90:536–544
Park CH, Suh JH, Yoo HS et al (1986) Evaluation of intrahepatic I-131 ethiodol on a patient with hepatocellular carcinoma. Therapeutic feasibility study. Clin Nucl Med 11:514–517
Raoul JL, Guyader D, Bretagne JF et al (1994) Randomized controlled trial for hepatocellular carcinoma with portal vein thrombosis: intra-arterial iodine-131-iodized oil versus medical support. J Nucl Med 35:1782–1787
Raoul JL, Guyader D, Bretagne JF et al (1997) Prospective randomized trial of chemoembolization versus intra-arterial injection of 131I-labeled-iodized oil in the treatment of hepatocellular carcinoma. Hepatology 26:1156–1161
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kirsch, M., Zinke, A., Kirsch, G., Hosten, N. (2008). Therapy with Intra-arterial Iodine-131-Lipiodol in Inoperable Hepatocellular Carcinoma. In: Vogl, T.J., Helmberger, T.K., Mack, M.G., Reiser, M.F. (eds) Percutaneous Tumor Ablation in Medical Radiology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68250-9_9
Download citation
DOI: https://doi.org/10.1007/978-3-540-68250-9_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-22518-8
Online ISBN: 978-3-540-68250-9
eBook Packages: MedicineMedicine (R0)