Abstract
The majority of primary and secondary malignant hepatic tumors are not suitable for surgical resection, which makes systemic chemotherapy treatments and/or local ablative therapies important components of intention-to-treat concepts or palliation. Tumor load and type of response determine the efficacy of these therapies.
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Andrews JC, Walker SC, Ackermann RJ, Cotton LA, Ensminger WD, Shapiro B (1994) Hepatic radioembolization with yttrium-90 containing glass microspheres: preliminary results and clinical follow-up. J Nucl Med 35:1637–1644
Ariel IM (1964) Radioactive isotopes for adjuvant cancer therapy. Arch Surg 89:244–249
Ariel IM, Padula G (1982) Treatment of asymptomatic metastatic cancer to the liver from primary colon and rectal cancer by the intraarterial administration of chemotherapy and radioactive isotopes. J Surg Oncol 20:151–156
Blanchard RJ, Grotenhuis I, LaFave JW (1964) Treatment of experimental tumors: utilization of radioactive microspheres. Arch Surg 89:406
Blanchard RJ, LaFave JW, Kim YS (1965) Treatment of patients with advanced cancer using Y-90 microspheres. Cancer 18:375
Burton MA, Gray BN, Klemp PF, Kelleher DK, Hardy N (1989) Selective internal radiation therapy: distribution of radiation in the liver. Eur J Cancer Clin Oncol 25:1487–1491
Carr B (2004) Hepatic arterial 90Yttrium glass microspheres (Therasphere) for unresectable hepatocellular carcinoma: interim safety and survival data on 65 patients. Liver Transplant 10[2, Suppl. 1]:107–110
Dancey JE, Shepherd FA, Paul K et al (2000) Treatment of nonresectable hepatocellular carcinoma with intrahepatic 90Y-microspheres. J Nucl Med 41:1673–1681
Dawson LA, McGinn CJ, Normolle D et al (2000) Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies. J Clin Oncol 18:2210–2218
Geschwind JF, Salem R, Carr BI et al (2004) Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Gastroenterology 127:S194–S205
Goin JE, Salem R, Carr BI et al (2005) Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: factors associated with liver toxicities. J Vasc Interv Radiol 16:205–213
Gray B, Van Hazel G, Hope M et al (2001) Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol 12:1711–1720
Gray BN, Burton MA, Kelleher DK, Anderson J, Klemp P (1989) Selective internal radiation (SIR) therapy for treatment of liver metastases: measurement of response rate. J Surg Oncol 42:192–196
Gray BN, Anderson JE, Burton MA et al (1992) Regression of liver metastases following treatment with yttrium-90 microspheres. Aust N Z J Surg 62:105–110
Hashimoto K, Ikeda Y, Korenaga D et al (2005) The impact of preoperative serum C-reactive protein on the prognosis of patients with hepatocellular carcinoma. Cancer 103:1856–1864
Herba MJ, Thirlwell MP (2002) Radioembolization for hepatic metastases. Semin Oncol 29:152–159
Ho S, Lau WY, Leung TW et al (1996) Partition model for estimating radiation doses from yttrium-90 microspheres in treating hepatic tumours. Eur J Nucl Med 23:947–952
Ho S, Lau WY, Leung TW et al (1997a) Tumour-to-normal uptake ratio of 90Y microspheres in hepatic cancer assessed with 99Tcm macroaggregated albumin. Br J Radiol 70:823–828
Ho S, Lau WY, Leung TW, Chan M, Johnson PJ, Li AK (1997b) Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer. Eur J Nucl Med 24:293–298
Kennedy AS, Salem R (2003) Comparison of two 90Yttrium microsphere agents for hepatic artery brachytherapy. Proceedings of the 14th International Congress on Anti-Cancer Treatment 2003, p 156
Kennedy AS, Nutting C, Coldwell D, Gaiser J, Drachenberg C (2004) Pathologic response and microdosimetry of 90Y microspheres in man: review of four explanted whole livers. Int J Radiat Oncol Biol Phys 60:1552–1563
Kennedy AS, Coldwell D, Nutting C et al (2006) Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases: Modern USA Experience. Int J Radiat Oncol Biol Phys 65:412–425
Kulik LM, Mulcahy MF, Hunter RD, Nemcek AA Jr., Abecassis MM, Salem R (2005) Use of yttrium-90 microspheres (TheraSphere) in a patient with unresectable hepatocellular carcinoma leading to liver transplantation: a case report. Liver Transpl 11:1127–1131
Kulik LM, Atassi B, van Holsbeeck L et al (2006) Yttrium-90 microspheres (TheraSphere) treatment of unresectable hepatocellular carcinoma: downstaging to resection, RFA and bridge to transplantation. J Surg Oncol 94:572–586
Lau WY, Ho S, Leung WT, Chan M, Lee WY, Johnson PJ (2001) What determines survival duration in hepatocellular carcinoma treated with intraarterial Yttrium-90 microspheres? Hepatogastroenterology 48:338–340
Lawrence TS, Robertson JM, Anscher MS, Jirtle RL, Ensminger WD, Fajardo LF (1995) Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys 31:1237–1248
Leung TW, Lau WY, Ho SK et al (1995) Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys 33:919–924
Lewandowski RJ, Thurston KG, Goin JE et al (2005) 90Y microsphere (TheraSphere) treatment for unresectable colorectal cancer metastases of the liver: response to treatment at targeted doses of 135–150 Gy as measured by [18F]fluorodeoxyglucose positron emission tomography and computed tomographic imaging. J Vasc Interv Radiol 16:1641–1651
Liu DM, Salem R, Bui JT et al (2005) Angiographic considerations in patients undergoing liver-directed therapy. J Vasc Interv Radiol 16:911–935
Liu MD, Uaje MB, Al-Ghazi MS et al (2004) Use of yttrium-90 TheraSphere for the treatment of unresectable hepatocellular carcinoma. Am Surg 70:947–953
Murthy R, Kennedy AS, Coldwell D et al (2002) Technical aspects of TheraSphere (TS) infusion. J Vasc Interv Radiol 13:S2
Murthy R, Brown DB, Salem R et al (2007) Gastrointestinal complications associated with hepatic arterial Yttrium-90 microsphere therapy. J Vasc Interv Radiol 18:553–561; quiz 562
Popperl G, Helmberger T, Munzing W, Schmid R, Jacobs TF, Tatsch K (2005) Selective internal radiation therapy with SIR-Spheres in patients with nonresectable liver tumors. Cancer Biother Radiopharm 20:200–208
Salem R, Thurston KG (2006) Radioembolization with 90Yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 1: Technical and methodologic considerations. J Vasc Interv Radiol 17:1251–1278
Salem R, Lewandowski RJ, Atassi B et al (2005) Treatment of unresectable hepatocellular carcinoma with use of 90Y microspheres (TheraSphere): safety, tumor response, and survival. J Vasc Interv Radiol 16:1627–1639
Steel J, Baum A, Carr B (2004) Quality of life in patients diagnosed with primary hepatocellular carcinoma: hepatic arterial infusion of Cisplatin versus 90-Yttrium microspheres (Therasphere). Psychooncology 13:73–79
Stefanovic L, Nikolic V, Obradovic M et al (2001) 131-I-lipiodol in therapy of liver carcinoma-methods and case report. Med Pregl 54:387–390
Stubbs RS, O’Brien I, Correia MM (2006) Selective internal radiation therapy with 90Y microspheres for colorectal liver metastases: single-centre experience with 100 patients. ANZ J Surg 76:696–703
Tateishi R, Yoshida H, Shiina S et al (2005) Proposal of a new prognostic model for hepatocellular carcinoma: an analysis of 403 patients. Gut 54:419–425
Van Hazel G, Blackwell A, Anderson J et al (2004) Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer. J Surg Oncol 88:78–85
Varela M, Sala M, Llovet JM, Bruix J (2003) Review article: natural history and prognostic prediction of patients with hepatocellular carcinoma. Aliment Pharmacol Ther 17[Suppl 2]:98–102
Wollner I, Knutsen C, Smith P et al (1988) Effects of hepatic arterial yttrium 90 glass microspheres in dogs. Cancer 61:1336–1344
Wong CY, Salem R, Qing F et al (2004) Metabolic response after intraarterial 90Y-glass microsphere treatment for colorectal liver metastases: comparison of quantitative and visual analyses by 18F-FDG PET. J Nucl Med 45:1892–1897
Wong JY, Shibata S, Williams LE et al (2003) A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer. Clin Cancer Res 9:5842–5852
Yorke ED, Jackson A, Fox RA, Wessels BW, Gray BN (1999) Can current models explain the lack of liver complications in Y-90 microsphere therapy? Clin Cancer Res 5:3024s–3030s
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Helmberger, T.K. (2008). Selective Internal Radiation Therapy. In: Vogl, T.J., Helmberger, T.K., Mack, M.G., Reiser, M.F. (eds) Percutaneous Tumor Ablation in Medical Radiology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68250-9_8
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DOI: https://doi.org/10.1007/978-3-540-68250-9_8
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