Abstract
The majority of medications used for IOP-lowering in adults are not licensed for use in children. Package inserts on topical medications warn that “safety and efficacy has not been established in children.” Despite this fact, most topical drops are used in children and are safe. Definitive trials to establish their safety and efficacy are unlikely to occur due to medicolegal constraints, namely, the difficulty in establishing accurate outcome measurements, limited sample sizes, and low financial incentives to drug companies evaluating products in the pediatric population [1].
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References
Wallace DK, Steinkuller PG (1998) Ocular medications in children. Clin Pediatr 37:645–652.
Patton TF, Robinson JR (1976) Pediatric dosing considerations in ophthalmology. J Pediatr Ophthalmol 13:171–178.
Shell JW (1982) Pharmacokinetics of topically applied ophthalmic drugs. Surv Ophthalmol 26:207–218.
Levy Y, Zadok D (2004) Systemic side effects of ophthalmic drops. Clin Pediatr (Phila) 43:99–101.
Berlin RJ, Lee UT, Samples JR, et al (2001) Ophthalmic drops causing coma in an infant. J Pediatr 138:441–443.
Passo MS, Palmer EA, Van Buskirk EM (1984) Plasma timolol in glaucoma patients. Ophthalmology 91:1361–1363.
Moore W, Nischal KK (2007) Pharmacologic management of glaucoma in childhood. Paediatr Drugs 9:71–79.
Ott EZ, Mills MD, Arango S, et al (2005) A randomized trial assessing dorzolamide in patient with glaucoma who are younger than 6 years. Arch Ophthalmol 123:1177–1186.
Morris S, Geh V, Nischal KK, et al (2003) Topical dorzolamide and metabolic acidosis in a neonate. Br J Ophthalmol 87:1052–1053.
Futagi Y, Otani K, Abe J (1996) Growth suppression in children receiving acetazolamide with antiepileptic drugs. Pediatr Neurol 15:323–326.
Enyedi LB, Freedman SF (2001) Safety and efficacy of brimonidine in children with glaucoma. J AAPOS 5:281–284.
Daubert GP (2006) Is brimonidine ophthalmic a safe therapy for infants? J Clin Pharm Ther 31:289–292.
Carlsen JO, Zabriskie NA, Kwon YH, et al (1999) Apparent central nervous system depression in infants after the use of topical brimonidine. Am J Ophthalmol 128:255–256.
Korsch E, Grote A, Seybold M, et al (1999) Systemic adverse effects of topical treatment with brimonidine in an infant with secondary glaucoma. Eur J Pediatr 158:685.
Watts P, Satterfield D, Lim MK (2007) Adverse effects of apraclonidine used in the diagnosis of Horner’s syndrome in infants. J AAPOS 11:282–283.
Schmidtborn F (1998) [Systemic side-effects of latanoprost in a child with aniridia and glaucoma]. Ophthalmologe 95: 633–634.
Enyedi LB, Freedman SF, Buckley EG (1999) The effectiveness of latanoprost for the treatment of pediatric glaucoma. J AAPOS 3:33–39.
Enyedi LB, Freedman SF (2002) Latanoprost for the treatment of pediatric glaucoma. Surv Ophthalmol 47: S129–S132.
Armaly MF (1963) Statistical attributes of the steroid hypertensive response in the clinically normal eye. I. The demonstration of three levels of response. Invest Ophthalmol 4:187–197.
Brookes JL, Khaw PT (2005) Steroid response in children. Clin Experiment Ophthalmol 33:229–230.
Lam DS, Fan DS, Ng JS, et al (2005) Ocular hypertensive and anti-inflammatory responses to different dosages of topical dexamethasone in children: A randomized trial. Clin Experiment Ophthalmol 33:252–258.
Lee YJ, Park CY, Woo KI (2006) Ocular hypertensive response to topical dexamethasone ointment in children. Korean J Ophthalmol 20:166–170.
Akingbehin AO (1983) Comparative study of the intraocular pressure effects of fluorometholone 0.1% versus dexamethasone 0.1%. Br J Ophthalmol 67:661–663.
Fan DS, Ng JS, Lam DS (2001) A prospective study on ocular hypertensive and antiinflammatory response to different dosages of fluorometholone in children. Ophthalmology 108:1973–1977.
Khan HA, Amitava AK (2007) Topical diclofenac versus dexamethasone after strabismus surgery: A double-blind randomized clinical trial of anti-inflammatory effect and ocular hypertensive response. Indian J Ophthalmol 55: 271–275.
Biedner BZ, David R, Grudsky A, et al (1980) Intraocular pressure response to corticosteroids in children. Br J Ophthalmol 64:430–431.
Dickerson JE Jr., Steely HT Jr., English-Wright SL, et al (1998) The effect of dexamethasone on integrin and laminin expression in cultured human trabecular meshwork cells. Exp Eye Res 66:731–738.
Putney LK, Brandt JD, O’Donnell ME (1997) Effects of dexamethasone on sodium-potassium-chloride cotransport in trabecular meshwork cells. Invest Ophthalmol Vis Sci 38:1229–1240.
Lo WR, Rowlette LL, Caballero M, et al (2003) Tissue differential microarray analysis of dexamethasone induction reveals potential mechanisms of steroid glaucoma. Invest Ophthalmol Vis Sci 44:473–485.
Reme C, d’Epinay SL (1981) Periods of development of the normal human chamber angle. Doc Ophthalmol 51:241–268.
Knepper PA, Breen M, Weinstein HG, et al (1978) Intraocular pressure and glycosaminoglycan distribution in the rabbit eye: Effect of age and dexamethasone. Exp Eye Res 27:567–575.
Knepper PA, Collins JA, Frederick R (1985) Effects of dexamethasone, progesterone, and testosterone on IOP and GAGs in the rabbit eye. Invest Ophthalmol Vis Sci 26: 1093–1100.
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Giaconi, J.A., Coppens, G., Zeyen, T. (2010). Pediatric Glaucoma: Glaucoma Medications and Steroids. In: Giaconi, J., Law, S., Coleman, A., Caprioli, J. (eds) Pearls of Glaucoma Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68240-0_51
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DOI: https://doi.org/10.1007/978-3-540-68240-0_51
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