Abstract
POAG is a less aggressive disease compared to angle-closure glaucoma and exfoliative glaucoma. There is evidence regarding the natural course of untreated glaucoma thanks to the St. Lucia study and the early manifest glaucoma trial (EMGT). In the St. Lucia Study, 29% of eyes that were reexamined after 10 years had developed end-stage glaucoma, while 16% of patients were blind in at least one eye [77]. Most patients were untreated during the 10-year interval between exams. In the EMGT, 76% of untreated early glaucoma patients progressed (according to specific study criteria for progression on visual fields) after a median follow-up of 8 years, although specific data regarding rates of blindness are not available [38].
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References
.The AGIS Investigators. (2000) The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol 130:429–440.
Araie M, Arai M, Koseki N, et al. (1995) Influence of myopic refraction on visual field defects in normal tension and primary open angle glaucoma. Jpn J Ophthalmol 39:60–64.
Bengtsson B, Heijl A. (2005) Diurnal IOP fluctuation: not an independent risk factor for glaucomatous visual field loss in high-risk ocular hypertension. Graefes Arch Clin Exp Ophthalmol 243:513–518.
Bengtsson B, Leske MC, Hyman L, et al. (2007) Fluctuation of intraocular pressure and glaucoma progression in the early manifest glaucoma trial. Ophthalmology 114: 205–209.
Boland MV, Quigley HA. (2007) Risk factors and open-angle glaucoma: classification and application. J Glaucoma 16:406–418.
Bonomi L, Marchini G, Marraffa M, et al. (2000) Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study. Ophthalmology 107:1287–1293.
Brandt JD. (2007) Central corneal thickness, tonometry, and glaucoma risk – a guide for the perplexed. Can J Ophthalmol 42:562–566.
Brandt JD, Beiser JA, Kass MA, et al. (2001) Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology 108:1779–1788.
Buhrmann RR, Quigley HA, Barron Y, et al. (2000) Prevalence of glaucoma in a rural East African population. Invest Ophthalmol Vis Sci 41:40–48.
Caprioli J, Coleman AL. (2008) Intraocular pressure fluctuation a risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study. Ophthalmology 115(7):1123–1129.
Chauhan BC, Hutchison DM, LeBlanc RP, et al. (2005) Central corneal thickness and progression of the visual field and optic disc in glaucoma. Br J Ophthalmol 89: 1008–1012.
Chen PP. (2003) Blindness in patients with treated open-angle glaucoma. Ophthalmology 110:726–733.
Chihara E, Sawada A. (1990) Atypical nerve fiber layer defects in high myopes with high-tension glaucoma. Arch Ophthalmol 108:228–232.
de Voogd S, Ikram MK, Wolfs RC, et al. (2005) Incidence of open-angle glaucoma in a general elderly population: the Rotterdam Study. Ophthalmology 112:1487–1493.
Ehlers N, Bramsen T, Sperling S. (1975) Applanation tonometry and central corneal thickness. Acta Ophthalmol (Copenh) 53:34–43.
Ekstrom C. (1996) Prevalence of open-angle glaucoma in central Sweden. The Tierp Glaucoma Survey. Acta Ophthalmol Scand 74:107–112.
European Glaucoma Prevention Study (EGPS) Group, Miglior S, Pfeiffer N, et al. (2007) Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study. Ophthalmology 114:3–9.
European Glaucoma Prevention Study Group, Pfeiffer N, Torri V, et al. (2007) Central corneal thickness in the European Glaucoma Prevention Study. Ophthalmology 114:454–459.
Feltgen N, Leifert D, Funk J. (2001) Correlation between central corneal thickness, applanation tonometry, and direct intracameral IOP readings. Br J Ophthalmol 85:85–87.
Forsius H. (1988) Exfoliation syndrome in various ethnic populations. Acta Ophthalmol Suppl 184:71–85.
Galassi F, Sodi A, Ucci F, et al. (2003) Ocular hemodynamics and glaucoma prognosis: a color Doppler imaging study. Arch Ophthalmol 121:1711–1715.
Gordon MO, Beiser JA, Brandt JD, et al. (2002) The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 120:714–20; discussion 829–30.
Grant WM, Burke JF, Jr. (1982) Why do some people go blind from glaucoma? Ophthalmology 89:991–998.
Green CM, Kearns LS, Wu J, et al. (2007) How significant is a family history of glaucoma? Experience from the Glaucoma Inheritance Study in Tasmania. Clin Experiment Ophthalmol 35:793–799.
Greve EL, Furuno F. (1980) Myopia and glaucoma. Albrecht Von Graefes Arch Klin Exp Ophthalmol 213:33–41.
Grodum K, Heijl A, Bengtsson B. (2005) Risk of glaucoma in ocular hypertension with and without pseudoexfoliation. Ophthalmology 112:386–390.
Grodum K, Heijl A, Bengtsson B. (2001) Refractive error and glaucoma. Acta Ophthalmol Scand 79:560–566.
Hattenhauer MG, Johnson DH, Ing HH, et al. (1998) The probability of blindness from open-angle glaucoma. Ophthalmology 105:2099–2104.
Heijl A, Leske MC, Bengtsson B, et al. (2002) Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 120:1268–1279.
Jonas JB, Gusek GC, Naumann GO. (1988) Optic disk morphometry in high myopia. Graefes Arch Clin Exp Ophthalmol 226:587–590.
Jonas JB, Stroux A, Velten I, et al. (2005) Central corneal thickness correlated with glaucoma damage and rate of progression. Invest Ophthalmol Vis Sci 46:1269–1274.
Kohlhaas M, Boehm AG, Spoerl E, et al. (2006) Effect of central corneal thickness, corneal curvature, and axial length on applanation tonometry. Arch Ophthalmol 124:471–476.
Kwon YH, Kim CS, Zimmerman MB, et al. (2001) Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma. Am J Ophthalmol 132:47–56.
Leske MC. (2007) Open-angle glaucoma – an epidemiologic overview. Ophthalmic Epidemiol 14:166–172.
Leske MC, Connell AM, Schachat AP, et al. (1994) The Barbados Eye Study. Prevalence of open angle glaucoma. Arch Ophthalmol 112:821–829.
Leske MC, Wu SY, Hennis A, et al. (2008) Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology 115:85–93.
Leske MC, Nemesure B, He Q, et al. (2001) Patterns of open-angle glaucoma in the Barbados Family Study. Ophthalmology 108:1015–1022.
Leske MC, Heijl A, Hyman L, et alet al. (2007) Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology 114:1965–1972.
Leske MC, Connell AM, Wu SY, et al. (2001) Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group. Arch Ophthalmol 119:89–95.
Leske MC, Wu SY, Honkanen R, et al. (2007) Nine-year incidence of open-angle glaucoma in the Barbados Eye Studies. Ophthalmology 114:1058–1064.
Mansberger SL, Cioffi GA. (2006) The probability of glaucoma from ocular hypertension determined by ophthalmologists in comparison to a risk calculator. J Glaucoma 15:426–431.
Mayama C, Suzuki Y, Araie M, et al. (2002) Myopia and advanced-stage open-angle glaucoma. Ophthalmology 109:2072–2077.
Medeiros FA, Sample PA, Weinreb RN. (2003) Corneal thickness measurements and frequency doubling technology perimetry abnormalities in ocular hypertensive eyes. Ophthalmology 110:1903–1908.
Medeiros FA, Sample PA, Weinreb RN. (2003) Corneal thickness measurements and visual function abnormalities in ocular hypertensive patients. Am J Ophthalmol 135:131–137.
Medeiros FA, Sample PA, Zangwill LM, et al. (2003) Corneal thickness as a risk factor for visual field loss in patients with preperimetric glaucomatous optic neuropathy. Am J OphthalÂmol 136:805–813.
Medeiros FA, Weinreb RN, Zangwill LM, et al. (2008) Long-term intraocular pressure fluctuations and risk of conversion from ocular hypertension to glaucoma. OphthalÂmology 115(6):934–940.
Mitchell P, Wang JJ, Hourihan F. (1999) The relationship between glaucoma and pseudoexfoliation: the Blue Mountains Eye Study. Arch Ophthalmol 117:1319–1324.
Mitchell P, Hourihan F, Sandbach J, et al. (1999) The relationship between glaucoma and myopia: the Blue Mountains Eye Study. Ophthalmology 106:2010–2015.
Mukesh BN, McCarty CA, Rait JL, et al. (2002) Five-year incidence of open-angle glaucoma: the visual impairment project. Ophthalmology 109:1047–1051.
Nemesure B, Honkanen R, Hennis A, et al. (2007) Incident open-angle glaucoma and intraocular pressure. OphthalÂmology 114:1810–1815.
Nicolela MT, McCormick TA, Drance SM, et al. (2003) Visual field and optic disc progression in patients with different types of optic disc damage: a longitudinal prospective study. Ophthalmology 110:2178–2184.
Nouri-Mahdavi K, Hoffman D, Coleman AL, et al. (2004) Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study. OphthalÂmology 111:1627–1635.
Ocular Hypertension Treatment Study Group, European Glaucoma Prevention Study Group, Gordon MO, et al. (2007) Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension. Ophthalmology 114:10–19.
Oliver JE, Hattenhauer MG, Herman D, et al. (2002) Blindness and glaucoma: a comparison of patients progressing to blindness from glaucoma with patients maintaining vision. Am J Ophthalmol 133:764–772.
Pache M, Flammer J. (2006) A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma. Surv Ophthalmol 51:179–212.
Perdicchi A, Iester M, Scuderi G, et al. (2007) Visual field damage and progression in glaucomatous myopic eyes. Eur J Ophthalmol 17:534–537.
Quigley HA. (1999) Proportion of those with open-angle glaucoma who become blind. Ophthalmology 106:2039–2041.
Quigley HA. (1996) Number of people with glaucoma worldwide. Br J Ophthalmol 80:389–393.
Quigley HA, Vitale S. (1997) Models of open-angle glaucoma prevalence and incidence in the United States. Invest Ophthalmol Vis Sci 38:83–91.
Quigley HA, Tielsch JM, Katz J, et al. (1996) Rate of progression in open-angle glaucoma estimated from cross-sectional prevalence of visual field damage. Am J Ophthalmol 122:355–363.
Quigley HA, West SK, Rodriguez J, et al. (2001) The prevalence of glaucoma in a population-based study of HispÂanic subjects: Proyecto VER. Arch Ophthalmol 119: 1819–1826.
Racette L, Wilson MR, Zangwill LM, et al. (2003) Primary open-angle glaucoma in blacks: a review. Surv Ophthalmol 48:295–313.
Ramakrishnan R, Nirmalan PK, Krishnadas R, et al. (2003) Glaucoma in a rural population of southern India: the Aravind comprehensive eye survey. Ophthalmology 110:1484–1490.
Rotchford AP, Johnson GJ. (2002) Glaucoma in Zulus: a population-based cross-sectional survey in a rural district in South Africa. Arch Ophthalmol 120:471–478.
Rudnicka AR, Mt-Isa S, Owen CG, et al. (2006) Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis. Invest Ophthalmol Vis Sci 47:4254–4261.
Schwartz B, Takamoto T, Martin J. (2004) Increased rate of visual field loss associated with larger initial visual field threshold values on follow-up of open-angle glaucoma. J Glaucoma 13:120–129.
Siddiqui Y, Ten Hulzen RD, Cameron JD, et al. (2003) What is the risk of developing pigmentary glaucoma from pigment dispersion syndrome? Am J Ophthalmol 135:794–799.
Sommer A, Tielsch JM, Katz J, et al. (1991) Racial differences in the cause-specific prevalence of blindness in east Baltimore. N Engl J Med 325:1412–1417.
Tielsch JM, Katz J, Sommer A, et al. (1995) Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol 113:216–221.
Tielsch JM, Katz J, Sommer A, et al. (1994) Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey. Arch Ophthalmol 112:69–73.
Tielsch JM, Sommer A, Katz J, et al. (1991) Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. JAMA 266:369–374.
Tokunaga T, Kashiwagi K, Tsumura T, et al. (2004) Association between nocturnal blood pressure reduction and progression of visual field defect in patients with primary open-angle glaucoma or normal-tension glaucoma. Jpn J Ophthalmol 48:380–385.
Varma R, Tielsch JM, Quigley HA, et al. (1994) Race-, age-, gender-, and refractive error-related differences in the normal optic disc. Arch Ophthalmol 112:1068–1076.
Varma R, Ying-Lai M, Francis BA, et al. (2004) PrevaÂlence of open-angle glaucoma and ocular hypertension in Latinos: the Los Angeles Latino Eye Study. Ophthalmology 111:1439–1448.
Vesti E, Kivela T. (2000) Exfoliation syndrome and exfoliation glaucoma. Prog Retin Eye Res 19:345–368.
Wiggs JL. (2007) Genetic etiologies of glaucoma. Arch Ophthalmol 125:30–37.
Wilson MR. (2002) Progression of visual field loss in untreated glaucoma patients and suspects in St Lucia, West Indies. Trans Am Ophthalmol Soc 100:365–410.
Wolfs RC, Klaver CC, Ramrattan RS, et al. (1998) Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study. Arch Ophthalmol 116: 1640–1645.
Wong TY, Klein BE, Klein R, et al. (2003) Refractive errors, intraocular pressure, and glaucoma in a white population. Ophthalmology 110:211–217.
Xu L, Li Y, Wang S, et al. (2007) Characteristics of highly myopic eyes: the Beijing Eye Study. Ophthalmology 114: 121–126.
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Nouri-Mahdavi, K. (2010). Risk Factors. In: Giaconi, J., Law, S., Coleman, A., Caprioli, J. (eds) Pearls of Glaucoma Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68240-0_22
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