Abstract
Numerous electrophysiological tests have been proposed for detecting glaucomatous damage. Some involve electrical recordings from the eye, while others involve recordings from the cortex [1]. The focus of this chapter is on the latter, particularly the VEP, an electrical potential recorded with one or more electrodes placed over the occipital region of the skull. A variety of visual displays have been used to record VEPs and standards are available that describe clinical recording and analysis of the “conventional” VEP [2]. While the VEP is useful in the diagnosis of a variety of conditions [3], to date there is no convincing evidence that any of the standard VEP procedures perform better than standard automated perimetry (SAP) for detecting glaucomatous damage. However, a relatively new technique, the multifocal VEP (mfVEP), can be clinically useful.
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References
Hood DC (2003) Objective measurement of visual function in glaucoma. Cur Opin Ophthalmol 14:78–82.
Holder GE, Brigell MG, Hawlina M, et al; International Society for Clinical Electrophysiology of Vision (2007) ISCEV standard for clinical pattern electroretinography – 2007 update. Doc Ophthalmol 114:111–6.
Brigell MG (2001) The visual evoked potential. In: Fishman, GA, Birch DG, Holder GE, Brigell MG (eds.) Electrophysiologic Testing in Disorders of the Retina, Optic Nerve, and Visual Pathway, 2nd edition (Ophthalmology Monographs). San Francisco: The Foundation of the American Academy of Ophthalmology, pp. 237–78.
Baseler HA, Sutter EE, Klein SA, Carney T (1994) The topography of visual evoked response properties across the visual field. Electroencephalogr Clin Neurophysiol 90:65–81.
Hood DC, Greenstein VC (2003) The multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma. Prog Retin Eye Res 22:201–51.
Hood DC, Zhang X, Greenstein VC, et al (2000) An interocular comparison of the multifocal VEP: a possible technique for detecting local damage to the optic nerve. Invest Ophthalmol Vis Sci 41:1580–7.
Goldberg I, Graham SL, Klistorner AI (2002) Multifocal objective perimetry in the detection of glaucomatous field loss. Am J Ophthalmol 133:29–39.
Graham SL, Klistorner AI, Grigg JR, Billson FA (2000) Objective VEP perimetry in glaucoma: asymmetry analysis to identify early deficits. J Glaucoma 9:10–9.
Graham SL, Klistorner AI, Goldberg I (2005) Clinical application of objective perimetry using multifocal visual evoked potentials in glaucoma practice. Arch Ophthalmol 123:729–39.
Fortune B, Hood DC (2003) Conventional pattern-reversal VEPs are not equivalent to summed multifocal VEPs. Invest Ophthalmol Vis Sci 44:1364–7.
Hood DC (2004) Electrophysiologic imaging of retinal and optic nerve damage: the multifocal technique. Ophthalmol Clin North Am 17:69–88.
Hood D, Odel JG, Winn BJ (2003) The multifocal visual evoked potential (VEP): applications and limitations in neuro-ophthalmology. J Neuro Ophthalmol 23:279–89.
Klistorner A, Graham SL (2000) Objective perimetry in glaucoma. Ophthalmol 107:2283–99.
Seiple W, Holopigian K, Clemens C, et al (2005) The multifocal visual evoked potential: an objective measure of visual field? Vision Res 45:1155–63.
Grippo TM, Hood DC, Kanadani FN, et al (2006) A comparison between multifocal and conventional VEP latency changes secondary to glaucomatous damage. Invest Ophthalmol Vis Sci 47:5331–6.
Hood DC, Chen, JY, Yang EB, et al (2006) The role of the multifocal visual evoked potential (mfVEP) latency in understanding optic nerve and retinal diseases. Trans Am Ophthalmol Soc 104:71–7.
Klistorner A, Graham SL, Martins A, et al (2007) Multifocal blue-on-yellow visual evoked potentials in early glaucoma. Ophthalmology 114:1613–21.
Rodarte C, Hood DC, Yang EB, et al (2006) The effects of glaucoma on the latency of the multifocal visual evoked potential. Br J Ophthalmol 90:1132–6.
Hood DC, Odel JG, Zhang X (2000) Tracking the recovery of local optic nerve function after optic neuritis: a multifocal VEP study. Invest Ophthalmol Vis Sci 41:4032–8.
Semela L, Yang EB, Hedges TR, et al (2007) Multifocal visual evoked potential in unilateral compressive optic neuropathy. Br J Ophthalmol 91:445–8.
Chen JY, Hood DC, Odel JG, Behrens MM (2006) The effects of retinal abnormalities on the multifocal visual evoked potential. Invest Ophthalmol Vis Sci 47:4378–85.
Fortune B, Demirel S, Zhang X, et al (2007) Comparing multifocal VEP and standard automated perimetry in high-risk ocular hypertension and early glaucoma. Invest Ophthalmol Vis Sci 48:1173–80.
Thienprasiddhi P, Greenstein VC, Chu DH, et al (2006) Detecting early functional damage in glaucoma suspect and ocular hypertensive patients with the multifocal VEP technique. J Glaucoma 15:321–7
Hood DC, Thienprasiddhi P, Greenstein VC, et al (2004) Detecting early to mild glaucomatous damage; a comparison of the multifocal VEP and automated perimetry. Invest Ophthalmol Vis Sci 45:492–8.
Massicotte EC, Semela L, Hedges TR (2005) Multifocal visual evoked potential in nonorganic visual field loss. Arch Ophthalmol 123:364–7.
Miele DL, Odel JG, Behrens, et al. (2000) Functional bitemporal quadrantopia and the multifocal visual evoked potential. J Neuro Ophthal 20:159–62.
Klistorner AI, Graham SL, Grigg JR, Billson FA (1998) Multifocal topographic visual evoked potential: improving objective detection of local visual field defects. Invest Ophthalmol Vis Sci 39:937–50.
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Hood, D.C., Ritch, R. (2010). Other Tests in Glaucoma: Multifocal Visual Evoked Potential. In: Giaconi, J., Law, S., Coleman, A., Caprioli, J. (eds) Pearls of Glaucoma Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68240-0_21
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