Abstract
Hematopoietic transplantation is increasingly being used as treatment for a variety of severe diseases. Data from International Registries indicate that more than 25,000 transplants are performed every year in Europe, and a similar number in the United States (US) (Copelan 2006; Gratwohl et al. 2007). The objectives of this procedure are: (1) to replace hematopoiesis affected by a severe and irreversible disorder, (2) to rescue the patient from intense marrow toxicity induced by high-dose chemotherapy and/or radiation, and (3) to use a fraction of cells contained in the graft as anti-tumor immunotherapy. Of note, one or more of these objectives may be pursued in a particular situation; for example, in a patient with acute leukemia, transplantation aims to replace the neoplastic hematopoiesis by administering high-dose cytotoxic therapy and taking advantage of the graft-versus-leukemia effect of donor T-lymphocytes from the graft. In contrast, in aplastic anemia the only goal of the procedure is to restore an adequate hematopoiesis.
Chapter PDF
Similar content being viewed by others
Keywords
- Bone Marrow Transplantation
- Invasive Aspergillosis
- Chronic GVHD
- Bronchiolitis Obliterans
- Diffuse Alveolar Hemorrhage
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F et al (2006) Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 108:1809–1820
Copelan EA (2006) Hematopoietic stem-cell transplantation. N Engl J Med 354:1813–1826
Gratwohl A, Baldomero H, Frauendorfer K, Urbano-Ispizua A, Niederwieser D for the Joint Accreditation Committee of the International Society for Cellular Therapy ISCT and the European Group for Blood and Marrow Transplantation EBMT (JACIE) (2007). Results of the EBMT activity survey 2005 on haematopoietic stem cell transplantation: focus on increasing use of unrelated donors. Bone Marrow Transplant 39:71–87
Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK et al (2005) Cotransplantation of HLAidentical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 11:389–398
Martino R, Caballero MD, Canals C, Simon JA, Solano C, Urbano-Ispizua A et al (2001) Allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning: results of a prospective multicentre study. Br J Haematol 115:653–659
Martino R, Caballero MD, Simon JA, Canals C, Solano C, Urbano-Ispizua A et al (2002) Evidence for a graft-versus-leukemia effect after allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in acute myelogenous leukemia and myelodysplastic syndromes. Blood 100:2243–2245
Ravandi F, Kantarjian H, Giles F, Cortes J (2004) New agents in acute myeloid leukemia and other myeloid disorders. Cancer 100:441–454
Thomas ED (1999) A history of haemopoietic cell transplantation. Br J Haematol 105:330–339
Thomas ED, Lochte HL, Ching-Lu W, Ferrebee J (1957) Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med 257:491–496
Xia G, Kovochich M, Truitt RL, Johnson BD (2004) Tracking ex vivo-expanded CD4+CD25+ and CD8+CD25+ regulatory T cells after infusion to prevent donor lymphocyte infusion-induced lethal acute graft-versus-host disease. Biol Blood Marrow Transplant 10:748–760
References
Afessa B, Tefferi A, Litzow MR, Peters SG (2002) Outcome of diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med 166:1364–1368
Alam S, Chan KM (1996) Noninfectious pulmonary complications after organ transplantation. Curr Opin Pulm Med 2:412–418
Alangaden GJ, Wahiduzzaman M, Chandrasekar PH (2002) Aspergillosis: the most common community-acquired pneumonia with Gram-negative Bacilli as copathogens in stem cell transplant recipients with graft-versus-host disease. Clin Infect Dis 35:659–664
Aljurf M, Gyger M, Alrajhi A, Sahovic E, Chaudhri N, Musa M, Ayoub 0, Seth P, Aslam M, Al-Fiar F (1999) Mycobacterium tuberculosis infection in allogeneic bone marrow transplantation patients. Bone Marrow Transplant 24:551–554
Allan BT, Patton D, Ramsey NK, Day DL (1988) Pulmonary fungal infections after bone marrow transplantation. Pediatr Radiol 18:118–122
Aquino SL, Kee ST, Warnock ML, Gamsu G (1994) Pulmonary aspergillosis: imaging findings with pathologic correlation. AJR Am J Roentgenol 163:811–815
Aquino SL, Gamsu G, Webb WR, Kee ST (1996) Tree-in-bud pattern: frequency and significance on thin section CT. J Comput Assist Tomogr 20:594–599
Aronchick JM (2000) Pulmonary infections in cancer and bone marrow transplant patients. Semin Roentgenol 35:140–151
Ascioglu S, Rex JH, de Pauw B, Bennett JE, Bille J, Crokaert F, Denning DW, Donnelly JP, Edwards JE, Erjavec Z, Fiere D, Lortholary O, Maertens J, Meis JF, Patterson TF, Ritter J, Selleslag D, Shah PM, Stevens DA, Walsh TJ (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34:7–14
Bag R (2003) Fungal pneumonias in transplant recipients. Curr Opin Pulm Med 9:193–198
Barker CC, Butzner JD, Anderson RA, Brant R, Sauve RS (2003) Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients. Bone Marrow Transplant 32:79–87
Ben-Abraham R, Paret G, Cohen R, Szold O, Cividalli G, Toren A, Nagler A (2003) Diffuse alveolar hemorrhage following allogeneic bone marrow transplantation in children. Chest 124:660–664
Bhagat R, Rizzieri DA, Vredenburgh JJ, Chao NJ, Folz RJ (2004) Pulmonary sarcoidosis following stem cell transplantation: is it more than a chance occurrence? Chest 126:642–644
Bhatia S, Louie AD, Bhatia R, O’Donnell MR, Fung H, Kashyap A, Krishnan A, Molina A, Nademanee A, Niland JC, Parker PA, Snyder DS, Spielberger R, Stein A, Forman SJ (2001) Solid cancers after bone marrow transplantation. J Clin Oncol 19:464–471
Bluemke DA, Fishman EK, Kuhlman JE, Zinreich ES (1991) Complications of radiation therapy: CT evaluation. Radiographies 11:581–600
Bodey GP, Vartivarian S (1989) Aspergillosis. Eur J Clin Microbiol Infect Dis 8:413–437
Boiselle PM, Tocino I, Hooley RJ, Pumerantz AS, Selwyn PA, Neklesa VP, Lange RC (1997) Chest radiograph interpretation of Pneumocystis carinii pneumonia, bacterial pneumonia, and pulmonary tuberculosis in HIV-positive patients: accuracy, distinguishing features, and mimics. J Thorac Imaging 12:47–53
Boiselle PM, Crans CA Jr, Kaplan MA (1999) The changing face of Pneumocystis carinii pneumonia in AIDS patients. AJR Am J Roentgenol 172:1301–1309
Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Cote S, Peret TC, Erdman DD, Anderson LJ (2002) Virological features and clinical manifestations associated with human metapneumovirus: a newparamyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis 186:1330–1334
Bragg DG, Chor PJ, Murray KA, Kjeldsberg CR (1994) Lymphoproliferative disorders of the lung: histopathology, clinical manifestations, and imaging features. AJR Am J Roentgenol 163:273–281
Buff SJ, McLelland R, Gallis HA, Matthay R, Putman CE (1982) Candida albicans pneumonia: radiographie appearance. AJR Am J Roentgenol 138:645–648
Busch FW, Bautz W, Dierkesmann R, Toomes H, Schalk KP, Rusch-Gerdes S, Ehninger G (1991) [Lung changes caused by Mycobacterium xenopi infection in a patient with bone marrow transplantation: problems in differential diagnosis]. Pneumologie 45:340–342
Cameron ML, Bartlett JA, Gallis HA, Waskin HA (1991) Manifestations of pulmonary cryptococcosis in patients with acquired immunodeficiency syndrome. Rev Infect Dis 13:64–67
Cardozo BL, Hagenbeek A (1985) Interstitial pneumonitis following bone marrow transplantation: pathogenesis and therapeutic considerations. Eur J Cancer Clin Oncol 21:43–51
Chakrabarti S, Avivi I, Mackinnon S, Ward K, Kottaridis PD, Osman H, Waldmann H, Hale G, Fegan CD, Yong K, Goldstone AH, Linch DC, Milligan DW (2002) Respiratory virus infections in transplant recipients after reducedintensity conditioning with Campath-1H: high incidence but low mortality. Br J Haematol 119:1125–1132
Chan CK, Hyland RH, Hutcheon MA (1990) Pulmonary complications following bone marrow transplantation. Clin Chest Med 11:323–332
Chen CS, Boeckh M, Seidel K, Clark JG, Kansu E, Madtes DK, Wagner JL, Witherspoon RP, Anasetti C, Appelbaum FR, Bensinger WI, Deeg HJ, Martin PJ, Sanders JE, Storb R, Storek J, Wade J, Siadak M, Flowers ME, Sullivan KM (2003) Incidence, risk factors, and mortality from pneumonia developing late after hematopoietic stem cell transplantation. Bone Marrow Transplant 32:515–522
Choi YH, Leung AN (1999) Radiologic findings: pulmonary infections after bone marrow transplantation. J Thorac Imaging 14:201–206
Conces DJ Jr, Stockberger SM, Tarver RD, Wheat LJ (1993) Disseminated histoplasmosis in AIDS: findings on chest radiographs. AJR Am J Roentgenol 160:15–19
Connolly JE Jr, McAdams HP, Erasmus JJ, Rosado-de-Christenson ML (1999) Opportunistic fungal pneumonia. J Thorac Imaging 14:51–62
Cooke KR, Yanik G (2004) Acute lung injury after allogeneic stem cell transplantation: is the lung a target of acute graft-versus-host disease? Bone Marrow Transplant 34:753–765
Cordonnier C (1990) [Clinical, diagnostic and physiopathological aspects of cytomegalovirus pneumonia after bone marrow transplantation]. Rev Pneumol Clin 46:244–250
Coy DL, Ormazabal A, Godwin JD, Lalani T (2005) Imaging evaluation of pulmonary and abdominal complications following hematopoietic stem cell transplantation. Radiographics 25:305–317; discussion 318
Crawford SW (1999) Noninfectious lung disease in the immunocompromised host. Respiration 66:385–395
Crawford SW, Hackman RC, Clark JG (1988) Open lung biopsy diagnosis of diffuse pulmonary infiltrates after marrow transplantation. Chest 94:949–953
Cunningham I (1992) Pulmonary infections after bone marrow transplant. Semin Respir Infect 7:132–138
Denning DW (2000) Early diagnosis of invasive aspergillosis. Lancet 355:423–424
Denning DW (2001) Chronic forms of pulmonary aspergillosis. Clin Microbiol Infect 7[Suppl 2]:25–31
Doucette K, Fishman JA (2004) Nontuberculous mycobacterial infection in hematopoietic stem cell and solid organ transplant recipients. Clin Infect Dis 38:1428–1439
Ellis SJ, Cleverley JR, Muller NL (2000) Drug-induced lung disease: high-resolution CT findings. AJR Am J Roentgenol 175:1019–1024
Epier GR (1995) Bronchiolitis obliterans organizing pneumonia. Semin Respir Infect 10:65–77
Ettinger NA (1993) Invasive diagnostic approaches to pulmonary infiltrates. Semin Respir Infect 8:168–176
Evans A, Steward CG, Lyburn ID, Grier DJ (2003) Imaging in haematopoietic stem cell transplantation. Clin Radiol 58:201–214
Foot AB, Caul EO, Roome AP, Darville JM, Oakhill A (1993) Cytomegalovirus pneumonitis and bone marrow transplantation: identification of a specific high risk group. J Clin Pathol 46:415–419
Franquet T, Müller NL, Gimenez A, Guembe P, de La Torre J, Bague S (2001) Spectrum of pulmonary aspergillosis: histologie, clinical, and radiologie findings. Radiographies 21:825–837
Franquet T, Serrano F, Gimenez A, Rodriguez-Arias JM, Puzo C (2002) Necrotizing Aspergillosis of large airways: CT findings in eight patients. J Comput Assist Tomogr 26:342–345
Franquet T, Lee KS, Muller NL (2003a) Thin-section CT findings in 32 immunocompromised patients with cytomegalovirus pneumonia who do not have AIDS. AJR Am J Roentgenol 181:1059–1063
Franquet T, Müller NL, Gimenez A, Martinez S, Madrid M, Domingo P (2003b) Infectious pulmonary nodules in immunocompromised patients: usefulness of computed tomography in predicting their etiology. J Comput Assist Tomogr 27:461–468
Franquet T, Müller NL, Oikonomou A, Flint JD (2004) Aspergillus infection of the airways: computed tomography and pathologic findings. J Comput Assist Tomogr 28:10–16
Franquet T, Müller NL, Lee KS, Gimenez A, Flint JD (2005a) High-resolution CT and pathologic findings of noninfectious pulmonary complications after hematopoietic stem cell transplantation. AJR Am J Roentgenol 184:629–637
Franquet T, Muller NL, Lee KS, Oikonomou A, Flint JD (2005b) Pulmonary candidiasis after hematopoietic stem cell transplantation: thin-section CT findings. Radiology 236: 332–337
Franquet T, Rodriguez S, Martino R, Salinas T, Gimenez A, Hidalgo A (2005c) Human metapneumovirus infection in hematopoietic stem cell transplant recipients: high-resolution computed tomography findings. J Comput Assist Tomogr 29:223–227
Franquet T, Rodriguez S, Hernandez JM, Martino R, Gimenez A, Hidalgo A, Domingo P (2007) Air-leak syndromes in hematopoietic stem cell transplant recipients with chronic GVHD. High-resolution CT findings. J Thorac Imaging (in press)
Freudenberger TD, Madtes DK, Curtis JR, Cummings P, Storer BE, Hackman RC (2003) Association between acute and chronic graft-versus-host disease and bronchiolitis obliterans organizing pneumonia in recipients of hematopoietic stem cell transplants. Blood 102:3822–3828
Fukuda T, Boeckh M, Guthrie KA, Mattson DK, Owens S, Wald A, Sandmaier BM, Corey L, Storb RF, Marr KA (2004) Invasive aspergillosis before allogeneic hematopoietic stem cell transplantation: 10-year experience at a single transplant center. Biol Blood Marrow Transplant 10:494–503
Gasparetto EL, Escuissato DL, Marchiori E, Ono S, Fraree Silva RL, Müller NL (2004) High-resolution CT findings of respiratory syncytial virus pneumonia after bone marrow transplantation. AJR Am J Roentgenol 182:1133–1137
Gasparetto EL, Escuissato DL, Inoue C, Marchiori E, Müller NL (2005) Herpes simplex virus type 2 pneumonia after bone marrow transplantation: high-resolution CT findings in 3 patients. J Thorac Imaging 20:71–73
Gaziev D, Baronciani D, Galimberti M, Polchi P, Angelucci E, Giardini C, Muretto P, Perugini S, Riggio S, Ghirlanda S, Erer B, Maiello A, Lucarelli G (1996) Mucormycosis after bone marrow transplantation: report of four cases in thalassemia and review of the literature. Bone Marrow Transplant 17:409–414
Ghosh S, Champlin R, Couch R, Englund J, Raad I, Malik S, Luna M, Whimbey E (1999) Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients. Clin Infect Dis 29:528–532
Giacchino M, Busca A, Miniero R, Defilippi C, Massara FM, Vassallo E, Madon E (1993) [Pulmonary complications after bone marrow transplantation], Minerva Pediatr 45:141–150
Gotway MB, Dawn SK, Caoili EM, Reddy GP, Araoz PA, Webb WR (2002) The radiologie spectrum of pulmonary Aspergillus infections. J Comput Assist Tomogr 26:159–173
Gulbahce HE, Manivel JC, Jessurun J (2000) Pulmonary cytolytic thrombi: a previously unrecognized complication of bone marrow transplantation. Am J Surg Pathol 24:1147–1152
Gulbahce HE, Pambuccian SE, Jessurun J, Woodard P, Steiner ME, Manivel JC, Hite S, Ramsay NK, Baker KS (2004) Pulmonary nodular lesions in bone marrow transplant recipients: impact of histologic diagnosis on patient management and prognosis. Am J Clin Pathol 121:205–210
Heurlin N, Brattstrom C, Lonnqvist B, Westman L, Lidman C, Andersson J (1991) Aetiology of pulmonary diseases in immunocompromised patients. Eur Respir J 4:10–18
Huaringa AJ, Leyva FJ, Signes-Costa J, Morice RC, Raad I, Darwish AA, Champlin RE (2000) Bronchoalveolar lavage in the diagnosis of pulmonary complications of bone marrow transplant patients. Bone Marrow Transplant 25:975–979
Ison MG, Hayden FG, Kaiser L, Corey L, Boeckh M (2003) Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumonia. Clin Infect Dis 36:1139–1143
Jantunen E, Piilonen A, Volin L, Ruutu P, Parkkali T, Koukila-Kahkola P, Ruutu T (2002) Radiologically guided fine needle lung biopsies in the evaluation of focal pulmonary lesions in allogeneic stem cell transplant recipients. Bone Marrow Transplant 29:353–356
Janzen DL, Padley SP, Adler BD, Muller NL (1993) Acute pulmonary complications in immunocompromised non-AIDS patients: comparison of diagnostic accuracy of CT and chest radiography. Clin Radiol 47:159–165
Kaiser L, Huguenin T, Lew PD, Chapuis B, Pittet D (1998) Invasive aspergillosis. Clinical features of 35 proven cases at a single institution. Medicine (Baltimore) 77:188–194
Kang EY, Patz EF Jr, Muller NL (1996) Cytomegalovirus pneumonia in transplant patients: CT findings. J Comput Assist Tomogr 20:295–299
Kantrow SP, Hackman RC, Boeckh M, Myerson D, Crawford SW (1997) Idiopathic pneumonia syndrome: changing spectrum of lung injury after marrow transplantation. Transplantation 63:1079–1086
Kapoor N, Copelan EA, Tutschka PJ (1989) Cytomegalovirus infection in bone marrow transplant recipients: use of intravenous gamma globulin as a prophylactic and therapeutic agent. Transplant Proc 21:3095–3096
Kauffman CA (2002) Endemic mycoses in patients with hematologie malignancies. Semin Respir Infect 17:106–112
Khoury MB, Godwin JD, Ravin CE, Gallis HA, Halvorsen RA, Putman CE (1984) Thoracic cryptococcosis: immunologie competence and radiologie appearance. AJR Am J Roentgenol 142:893–896
Khurshid I, Anderson LC (2002) Non-infectious pulmonary complications after bone marrow transplantation. Postgrad Med J 78:257–262
Kotloff RM, Ahya VN, Crawford SW (2004) Pulmonary complications of solid organ and hematopoietic stem cell transplantation. Am J Respir Crit Care Med 170:22–48
Krinzman S, Basgoz N, Kradin R, Shepard JA, Flieder DB, Wright CD, Wain JC, Ginns LC (1998) Respiratory syncytial virus-associated infections in adult recipients of solid organ transplants. J Heart Lung Transplant 17:202–210
Krowka MJ, Rosenow EC 3rd, Hoagland HC (1985) Pulmonary complications of bone marrow transplantation. Chest 87:237–246
Kuhlman JE, Fishman EK, Siegelman SS (1985) Invasive pulmonary aspergillosis in acute leukemia: characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis. Radiology 157:611–614
Kuhlman JE, Fishman EK, Burch PA, Karp JE, Zerhouni EA, Siegelman SS (1987) Invasive pulmonary aspergillosis in acute leukemia. The contribution of CT to early diagnosis and aggressive management. Chest 92:95–99
Kuhlman JE, Fishman EK, Burch PA, Karp JE, Zerhouni EA, Siegelman SS (1988) CT of invasive pulmonary aspergillosis. AJR Am J Roentgenol 150:1015–1020
Kumar K, Jimenez V (2001) Pulmonary nocardiosis after bone marrow transplantation successfully treated with doxycycline. Int J Infect Dis 5:222–224
Leung AN, Gosselin MV, Napper CH, Braun SG, Hu WW, Wong RM, Gasman J (1999) Pulmonary infections after bone marrow transplantation: clinical and radiographie findings. Radiology 210:699–710
Libshitz HI, Zornoza J, McLarty JW (1978) Lung cancer in chronic leukemia and lymphoma. Radiology 127:297–300
Lin JT, Lee MY, Hsiao LT, Yang MH, Chao TC, Chen PM, Chiou TJ (2004) Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation. Ann Hematol 83:444–446
Ljungman P (2001) Respiratory virus infections in stem cell transplant patients: the European experience. Biol Blood Marrow Transplant Suppl 7:5S–7S
Lorigan JG, Libshitz HI, Peuchot M (1989) Radiation-induced sarcoma of bone: CT findings in 19 cases. AJR Am J Roentgenol 153:791–794
Maertens J, Demuynck H, Verbeken EK, Zachee P, Verhoef GE, Vandenberghe P, Boogaerts MA (1999) Mucormycosis in allogeneic bone marrow transplant recipients: report of five cases and review of the role of iron overload in the pathogenesis. Bone Marrow Transplant 24:307–312
Maertens J, Verhaegen J, Lagrou K, Van Eldere J, Boogaerts M (2001) Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation. Blood 97:1604–1610
Markovic SN, Adlakha A, Smith TF, Walker RC (1998) Respiratory syncytial virus pneumonitis-induced diffuse alveolar damage in an autologous bone marrow transplant recipient. Mayo Clin Proc 73:153–156
Martino R, Manteiga R, Sanchez I, Brunet S, Sureda A, Badell I, Argiles B, Subira M, Bordes R, Domingo-Albos A (1995) Viridans streptococcal shock syndrome during bone marrow transplantation. Acta Haematol 94:69–73
Martino R, Martinez C, Brunet S, Sureda A, Lopez R, Do-mingo-Albos A (1996) Tuberculosis in bone marrow transplant recipients: report of two cases and review of the literature. Bone Marrow Transplant 18:809–812
Maschmeyer G (2001) Pneumonia in febrile neutropenic patients: radiologic diagnosis. Curr Opin Oncol 13:229–235
McAdams HP, Rosado-de-Christenson ML, Lesar M, Templeton PA, Moran CA (1995) Thoracic mycoses from endemic fungi: radiologie-pathologie correlation. Radiographics 15:255–270
McAdams HP, Rosado de Christenson M, Strollo DC, Patz EF Jr (1997) Pulmonary mucormycosis: radiologie findings in 32 cases. AJR Am J Roentgenol 168:1541–1548
Mohite U, Das M, Saikia T, Parikh P, Gopal R, Kelkar R, Advani S (2001) Mycobacterial pulmonary infection post allogeneic bone marrow transplantation. Leuk Lymphoma 40:675–678
Navari RM, Sullivan KM, Springmeyer SC, Siegel MS, Meyers JD, Buckner CD, Sanders JE, Stewart PS, Clift RA, Fefer A et al (1983) Mycobacterial infections in marrow transplant patients. Transplantation 36:509–513
Nichols WG, Corey L, Gooley T, Davis C, Boeckh M (2001) Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome. Blood 98:573–578
Nichols WG, Guthrie KA, Corey L, Boeckh M (2004) Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy. Clin Infect Dis 39:1300–1306
Nusair S, Breuer R, Shapira MY, Berkman N, Or R (2004) Low incidence of pulmonary complications following nonmyeloablative stem cell transplantation. Eur Respir J 23:440–445
Oikonomou A, Muller NL, Nantel S (2003) Radiographie and high-resolution CT findings of influenza virus pneumonia in patients with hematologie malignancies. AJR Am J Roentgenol 181:507–511
Ooi GC, Peh WC, Ip M (1998) High-resolution computed tomography of bronchiolitis obliterans syndrome after bone marrow transplantation. Respiration 65:187–191
Ozkaynak MF, Lenarsky C, Kohn D, Weinberg K, Parkman R (1990) Mycobacterium avium-intracellulare infections after allogeneic bone marrow transplantation in children. Am J Pediatr Hematol Oncol 12:220–224
Patriarca F, Skert C, Sperotto A, Damiani D, Cerno M, Geromin A, Zaja F, Stocchi R, Prosdocimo S, Fili C, Fanin R (2004) Incidence, outcome, and risk factors of late-onset noninfectious pulmonary complications after unrelated donor stem cell transplantation. Bone Marrow Transplant 33:751–758
Paulin T, Ringden O, Nilsson B, Lonnqvist B, Gahrton G (1987) Variables predicting bacterial and fungal infections after allogeneic marrow engraftment. Transplantation 43:393–398
Pickhardt PJ, Siegel MJ, Hayashi RJ, Kelly M (2000) Posttransplantation lymphoproliferative disorder in children: clinical, histopathologic, and imaging features. Radiology 217:16–25
Primack SL, Hartman TE, Lee KS, Muller NL (1994) Pulmonary nodules and the CT halo sign. Radiology 190:513–515
Rappaport DC, Chamberlain DW, Shepherd FA, Hutcheon MA (1998) Lymphoproliferative disorders after lung transplantation: imaging features. Radiology 206:519–524
Resnick IB, Averbuch D, Aker M, Engelhard D (2005) Is Pneumocystis carinii pneumonia after stem cell transplantations a contagious disease? Clin Transplant 19:427–431
Roviaro G, Varoli F, Francese M, Caminiti R, Vergani C, Ma-ciocco M (2002) Thoracoscopy andtransplantation: a new attractive tool. Transplantation 73:1013–1018
Roy V, Weisdorf D (1997) Mycobacterial infections following bone marrow transplantation: a 20 year retrospective review. Bone Marrow Transplant 19:467–470
Saito T, Seo S, Kanda Y, Shoji N, Ogasawara T, Murakami J, Tanosaki R, Tobinai K, Takaue Y, Mineishi S (2001) Early onset Pneumocystis carinii pneumonia after allogeneic peripheral blood stem cell transplantation. Am J Hematol 67:206–209
Schmidt-Wolf I, Schwerdtfeger R, Schwella N, Gallardo J, Schmid HJ, Huhn D, Siegert W (1993) Diffuse pulmonary alveolar hemorrhage after allogeneic bone marrow transplantation. Ann Hematol 67:139–141
Sider L, Westcott MA (1994) Pulmonary manifestations of cryptococcosis in patients with AIDS: CT features. J Thorac Imaging 9:78–84
Snyder CL, Ramsay NK, McGlave PB, Ferrell KL, Leonard AS (1990) Diagnostic open-lung biopsy after bone marrow transplantation. J Pediatr Surg 25: 871–876; discussion 876–877
Soubani AO, Miller KB, Hassoun PM (1996) Pulmonary complications of bone marrow transplantation. Chest 109:1066–1077
Soubani AO, Qureshi MA, Baynes RD (2001) Flexible bronchoscopy in the diagnosis of pulmonary infiltrates following autologous peripheral stem cell transplantation for advanced breast cancer. Bone Marrow Transplant 28:981–985
Springmeyer SC, Hackman RC, Holle R, Greenberg GM, Weems CE, Myerson D, Meyers JD, Thomas ED (1986) Use of bronchoalveolar lavage to diagnose acute diffuse pneumonia in the immunocompromised host. J Infect Dis 154:604–610
Starobin D, Fink G, Shitrit D, Izbicki G, Bendayan D, Bakal I, Kramer MR (2003) The role of fiberoptic bronchoscopy evaluating transplant recipients with suspected pulmonary infections: analysis of 168 cases in a multiorgan transplantation center. Transplant Proc 35:659–660
Stover DE, Zaman MB, Hajdu SI, Lange M, Gold J, Armstrong D (1984) Bronchoalveolar lavage in the diagnosis of diffuse pulmonary infiltrates in the immunosuppressed host. Ann Intern Med 101:1–7
Stringer JR, Beard CB, Miller RF, Wakefield AE (2002) A new name (Pneumocystis jiroveci) for Pneumocystis from humans. Emerg Infect Dis 8:891–896
Tabbara IA, Zimmerman K, Morgan C, Nahleh Z (2002) Allogeneic hematopoietic stem cell transplantation: complications and results. Arch Intern Med 162:1558–1566
Tanaka N, Matsumoto T, Miura G, Emoto T, Matsunaga N (2002) HRCT findings of chest complications in patients with leukemia. Eur Radiol 12:1512–1522
Tazelaar HD, Baird AM, Mill M, Grimes MM, Schulman LL, Smith CR (1989) Bronchocentric mycosis occurring in transplant recipients. Chest 96:92–95
Urbanski SJ, Kossakowska AE, Curtis J, Chan CK, Hutcheon MA, Hyland RH, Messner H, Minden M, Sculier JP (1987) Idiopathic small airways pathology in patients with graft versus-host disease following allogeneic bone marrow transplantation. Am J Surg Pathol 11:965–971
Verfaillie C, Weisdorf D, Haake R, Hostetter M, Ramsay NK, McGlave P (1991) Candida infections in bone marrow transplant recipients. Bone Marrow Transplant 8:177–184
Vilchez RA, Linden P, Lacomis J, Costello P, Fung J, Kusne S (2001) Acute respiratory failure associated with pulmonary cryptococcosis in non-aids patients. Chest 119:1865–1869
Villablanca JG, Steiner M, Kersey J, Ramsay NK, Ferrieri P, Haake R, Weisdorf D (1990) The clinical spectrum of infections with viridans streptococci in bone marrow transplant patients. Bone Marrow Transplant 5:387–393
Wah TM, Moss HA, Robertson RJ, Barnard DL (2003) Pulmonary complications following bone marrow transplantation. Br J Radiol 76:373–379
Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, Wright PF, Crowe JE Jr (2004) Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 350:443–450
Winer-Muram HT, Gurney JW, Bozeman PM, Krance RA (1996) Pulmonary complications after bone marrow transplantation. Radiol Clin North Am 34:97–117
Wong PW, Stefanec T, Brown K, White DA (2002) Role of fine-needle aspirates of focal lung lesions in patients with hematologic malignancies. Chest 121:527–532
Worthy SA, Flint JD, Muller NL (1997) Pulmonary complications after bone marrow transplantation: high-resolution CT and pathologic findings. Radiographics 17:1359–1371
Yen KT, Lee AS, Krowka MJ, Burger CD (2004) Pulmonary complications in bone marrow transplantation: a practical approach to diagnosis and treatment. Clin Chest Med 25:189–201
Young JA, Hopkin JM, Cuthbertson WP (1984) Pulmonary infiltrates in immunocompromised patients: diagnosis by cytological examination of bronchoalveolar lavage fluid. J Clin Pathol 37:390–397
Zihlif M, Khanchandani G, Ahmed HP, Soubani AO (2005) Surgical lung biopsy in patients with hematological malignancy or hematopoietic stem cell transplantation and unexplained pulmonary infiltrates: improved outcome with specific diagnosis. Am J Hematol 78:94–99
Zinck SE, Leung AN, Frost M, Berry GJ, Muller NL (2002) Pulmonary cryptococcosis: CT and pathologic findings. J Comput Assist Tomogr 26:330–334
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Sierra, J., Franquet, T. (2008). Bone Marrow Transplantation. In: Bankier, A.A. (eds) Imaging in Transplantation. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68218-9_6
Download citation
DOI: https://doi.org/10.1007/978-3-540-68218-9_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-40229-9
Online ISBN: 978-3-540-68218-9
eBook Packages: MedicineMedicine (R0)