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Cell Adhesion pp 343-372 | Cite as

Roles of Nectins in Cell Adhesion, Signaling and Polarization

Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 165)

Abstract

Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules which constitute a family of four members. Nectins homophilically and heterophilically trans-interact and cause cell-cell adhesion. This nectin-based cell-cell adhesion plays roles in the organization of adherens junctions in epithelial cells and fibroblasts and synaptic junctions in neurons in cooperation with cadherins. The nectin-based cell-cell adhesion plays roles in the contacts between commissural axons and floor plate cells and in the organization of Sertoli cell-spermatid junctions in the testis, independently of cadherins. Nectins furthermore regulate intracellular signaling through Cdc42 and Rac small G proteins and cell polarization through cell polarity proteins. Pathologically, nectins serve as entry and cell-cell spread mediators of herpes simplex viruses.

Keywords

Nectin Afadin Adherens junctions Tight junctions Cell signaling Cell polarity Small G proteins 
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© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Department of Molecular Biology and BiochemistryOsaka University Graduate School of Medicine/Faculty of MedicineSuita, OsakaJapan

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