Summary
In the present study the goal was to quantify the stresses acting locally on pulmonary epithelial cells in order to better understand the dynamic behavior of these cells. To quantify mechanotransduction responses, one must first understand the magnitude and distribution of stresses on the epithelial cells. It was investigated a two-dimensional, mathematical model of airway reopening, using a flow-driven semi-infinite bubble progressing through an airway as it clears a liquid occlusion was created. The flow in this system was highly viscous, and thus was governed by Stokes equations. This 2-D model was solved computationally using the boundary element method (BEM) in conjunction with lubrication approximations. Algebraic expressions were developed that could be used simply and accurately predict the fluid stress based upon the fluid viscosity, μ, channel height, H, cell size, A, and flow-rate, Q. From the solution, it was determined the stationary-state stresses acting on the epithelial cells. The results indicated that the magnitude of both the x- and y-stresses acting on the walls’ cells were directly related to the cell protuberance topography and produced a complex stress field.
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Kuraszkiewicz, B. (2008). Modeling and Simulation of Airway Tissues Stresses during Pulmonary Recruitment. In: Pietka, E., Kawa, J. (eds) Information Technologies in Biomedicine. Advances in Soft Computing, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68168-7_22
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DOI: https://doi.org/10.1007/978-3-540-68168-7_22
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