Clinical BOLD fMRI: Artifacts, Tips and Tricks

  • Ronald Peeters
  • Stefan Sunaert
Part of the Medical Radiology book series (MEDRAD)


BOLD-fMRI is prone to different artifacts and sources of error. These artifacts can have a technical origin, like susceptibility artifacts in specific brain regions, but they can also be related to brain physiology such as activation in draining veins that may occur in the vicinity of functionally active regions or flow artifacts. There are also several specific effects related to pathology that can effect clinical fMRI and therefore can lead to medical misinterpretation, e.g. alterations or absence of BOLD-signals induced by various brain lesions. The same holds true for pharmacological effects on BOLD-imaging in patients receiving medication. Reduced cooperation of the patients during scanning or marked head motion are practical problems in clinical neuroimaging and especially in fMRI. Therefore the success of clinical fMRI depends considerably on the clinician’s/technician’s ability to recognize and cope with these technical, physiological and patient induced artifacts and sources of error.


Functional Magnetic Resonance Imaging Blood Oxygenation Level Dependent Magn Reson Image Blood Oxygenation Level Dependent Signal Signal Intensity Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Ronald Peeters
    • 1
  • Stefan Sunaert
    • 1
  1. 1.Department of RadiologyUniversity Hospitals of the Catholic University of LeuvenLeuvenBelgium

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