Adenosine kinase

Part of the Springer Handbook of Enzymes book series (HDBKENZYMES, volume 35)


EC number

Systematic name

ATP:adenosine 5’-phosphotransferase

Recommended name

adenosine kinase


adenosine kinase (phosphorylating)

kinase, adenosine (phosphorylating)

CAS registry number



Ammonium Sulfate Trypanosoma Cruzi Purine Nucleoside Entamoeba Histolytica Purine Nucleoside Phosphorylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Lazou, A.; Beis, I.: Enzymes of adenosine metabolism in Rana ridibunda heart. Mol. Physiol., 8, 131–142 (1985)Google Scholar
  2. [2]
    Lobelle-Rich, P.A.; Reeves, R.E.: The partial purification and characterization of adenosine kinase from Entamoeba histolytica. Am. J. Trop. Med. Hyg., 32, 976–979 (1983)PubMedGoogle Scholar
  3. [3]
    De Jong, J.W.: Partial purification and properties of rat heart adenosine kinase. Arch. Int. Physiol. Biochim., 85, 557–569 (1977)PubMedCrossRefGoogle Scholar
  4. [4]
    Chen, C.-M.; Eckert, R.L.: Phosphorylation of cytokinin by adenosine kinase from wheat germ. Plant Physiol., 59, 443–447 (1977)PubMedCrossRefGoogle Scholar
  5. [5]
    Divekar, A.Y.; Hakala, M.T.; Chheda, G.B.; Hong, C.I.: 6-Ureido derivatives of 9-(-d-ribofuranosyl)purine as inhibitors of adenosine kinase. Biochem. Pharmacol., 22, 545–548 (1973)PubMedCrossRefGoogle Scholar
  6. [6]
    Lindberg, B.; Klenow, H.; Hansen, K.: Some properties of partially purified mammalian adenosine kinase. J. Biol. Chem., 242, 350–356 (1967)PubMedGoogle Scholar
  7. [7]
    Yamada, Y.; Goto, H.; Ogasawara, N.: Purine nucleoside kinases in human T-and B-lymphoblasts. Biochim. Biophys. Acta, 761, 34–40 (1983)PubMedGoogle Scholar
  8. [8]
    De Jong, J.W.; Kalkman, C.: Myocardial adenosine kinase: activity and localization determined with rapid, radiometric assay. Biochim. Biophys. Acta, 320, 388–396 (1973)PubMedGoogle Scholar
  9. [9]
    Hawkins, C.F.; Bagnara, A.S.: Adenosine kinase from human erythrocytes: kinetic studies and characterization of adenosine binding sites. Biochemistry, 26, 1982–1987 (1987)PubMedCrossRefGoogle Scholar
  10. [10]
    Andres, C.M.; Fox, I.H.: Purification and properties of human placental adenosine kinase. J. Biol. Chem., 254, 11388–11393 (1979)PubMedGoogle Scholar
  11. [11]
    Palella, T.D.; Andres, C.M.; Fox, I.H.: Human placental adenosine kinase. Kinetic mechanism and inhibition. J. Biol. Chem., 255, 5264–5269 (1980)PubMedGoogle Scholar
  12. [12]
    Yamada, Y.; Goto, H.; Ogasawara, N.: Adenosine kinase from human liver. Biochim. Biophys. Acta, 660, 36–43 (1981)PubMedGoogle Scholar
  13. [13]
    Bone, R.; Cheng, Y.-C.; Wolfenden, R.: Inhibition of adenosine and thymidylate kinases by bisubstrate analogs. J. Biol. Chem., 261, 16410–16413 (1986)PubMedGoogle Scholar
  14. [14]
    Rotllan, P.; Miras Portugal, M.T.: Adenosine kinase from bovine adrenal medulla. Eur. J. Biochem., 151, 365–371 (1985)PubMedCrossRefGoogle Scholar
  15. [15]
    Miller, R.L.; Adamczyk, D.L.; Miller, W.H.: Adenosine kinase from rabbit liver. I. Purification by affinity chromatography and properties. J. Biol. Chem., 254, 2339–2345 (1979)PubMedGoogle Scholar
  16. [16]
    Miller, R.L.; Adamczyk, D.L.; Miller, W.H.; Koszalka, G.W.; Rideout, J.L.; Beacham, L.M.; Chao, E.Y.; Haggerty, J.J.; Krenitsky, T.A.; Elion, G.B.: Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity. J. Biol. Chem., 254, 2346–2352 (1979)PubMedGoogle Scholar
  17. [17]
    Drabikowska, A.K.; Halec, L.; Shugar, D.: Purification and properties of adenosine kinase from rat liver: separation from deoxyadenosine kinase activity. Z. Naturforsch. C, 40c, 34–41 (1985)Google Scholar
  18. [18]
    Yamada, Y.; Goto, H.; Ogasawara, N.: Purification and properties of adenosine kinase from rat brain. Biochim. Biophys. Acta, 616, 199–207 (1980)PubMedGoogle Scholar
  19. [19]
    Fisher, M.N.; Newsholme, E.A.: Properties of rat heart adenosine kinase. Biochem. J., 221, 521–528 (1984)PubMedGoogle Scholar
  20. [20]
    Mimouni, M.; Bontemps, F.; Van den Berghe, G.: Kinetic studies of rat liver adenosine kinase. Explanation of exchange reaction between adenosine and AMP. J. Biol. Chem., 269, 17820–17825 (1994)PubMedGoogle Scholar
  21. [21]
    Chang, C.-H.; Brockman, R.W.; Bennett, L.L.: Adenosine kinase from L1210 cells. Purification and some properties of the enzyme. J. Biol. Chem., 255, 2366–2371 (1980)PubMedGoogle Scholar
  22. [22]
    Henderson, J.F.; Mikoshiba, A.; Chu, S.Y.; Caldwell, I.C.: Kinetic studies of adenosine kinase from Ehrlich ascites tumor cells. J. Biol. Chem., 247, 1972–1975 (1972)PubMedGoogle Scholar
  23. [23]
    Guranowski, A.: Plant adenosine kinase: purification and some properties of the enzyme from Lupinus luteus seeds. Arch. Biochem. Biophys., 196, 220–226 (1979)PubMedCrossRefGoogle Scholar
  24. [24]
    Kidder, G.W.: Adenosine kinase from Trypanosoma cruzi. Biochem. Biophys. Res. Commun., 107, 381–388 (1982)PubMedCrossRefGoogle Scholar
  25. [25]
    Datta, A.K.; Bhaumik, D.; Chatterjee, R.: Isolation and characterization of adenosine kinase from Leishmania donovani. J. Biol. Chem., 262, 5515–5521 (1987)PubMedGoogle Scholar
  26. [26]
    Bhaumik, D.; Datta, A.K.: Immunochemical and catalytic characteristics of adenosine kinase from Leishmania donovani. J. Biol. Chem., 264, 4356–4361 (1989)PubMedGoogle Scholar
  27. [27]
    Carson, D.A.; Kaye, J.; Seegmiller, J.E.: Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s). Proc. Natl. Acad. Sci. USA, 74, 5677–5681 (1977)PubMedCrossRefGoogle Scholar
  28. [28]
    Leibach, T.K.; Spiess, G.I.; Neudecker, T.J, Peschke, G.J.; Puchwein, G.; Hartmann, G.R.: Purification and properties of adenosine kinase from dried brewers yeast. Hoppe-Seyler’s Z. Physiol. Chem., 352, 328–344 (1971)PubMedGoogle Scholar
  29. [29]
    Schmidt, G.; Walker, R.D.; Konigk, E.: Adenosine kinase from normal mouse erythrocytes and from Plasmodium chabaudi: partial purification and characterization. Tropenmed. Parasitol., 25, 301–308 (1974)PubMedGoogle Scholar
  30. [30]
    von Schwartzenberg, K.; Kruse, S.; Reski, R.; Moffatt, B.; Laloue, M.: Cloning and characterization of an adenosine kinase from Physcomitrella involved in cytokinin metabolism. Plant J., 13, 249–257 (1998)CrossRefGoogle Scholar
  31. [31]
    Recacha, R.; Talalaev, A.; DeLucas, L.J.; Chattopadhyay, D.: Toxoplasma gondii adenosine kinase: expression, purification, characterization, crystallization and preliminary crystallographic analysis. Acta Crystallogr. Sect. D, 56 (Pt 1), 76–78 (2000)CrossRefGoogle Scholar
  32. [32]
    Carret, C.; Delbecq, S.; Labesse, G.; Carcy, B.; Precigout, E.; Moubri, K.; Schetters, T.P.; Gorenflot, A.: Characterization and molecular cloning of an adenosine kinase from Babesia canis rossi. Eur. J. Biochem., 265, 1015–1021 (1999)PubMedCrossRefGoogle Scholar
  33. [33]
    Barrado, P.; Rodriguez, M.J.; Jimenez, A.; Lobato, M.F.: Expression in Escherichia coli of a recombinant adenosine kinase from Saccharomyces cerevisiae: purification, kinetics and substrate analyses. Yeast, 20, 1145–1150 (2003)PubMedCrossRefGoogle Scholar
  34. [34]
    Faye, F.; Le Floc’h, F.: Adenosine kinase of peach tree flower buds: purification and properties. Plant Physiol. Biochem., 35, 15–22 (1997)Google Scholar
  35. [35]
    Faye, F.; Le Floc’h, F.: Changes in the activity of peach bud adenosine kinase from the dormancy period to bud break. J. Plant Physiol., 154, 471–476 (1999)Google Scholar
  36. [36]
    Laukens, K.; Lenobel, R.; Strnad, M.; Van Onckelen, H.; Witters, E.: Cytokinin affinity purification and identification of a tobacco BY-2 adenosine kinase. FEBS Lett., 533, 63–66 (2003)PubMedCrossRefGoogle Scholar
  37. [37]
    Schumacher, M.A.; Scott, D.M.; Mathews, I.I.; Ealick, S.E.; Roos, D.S.; Ullman, B.; Brennan, R.G.: Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. J. Mol. Biol., 296, 549–567 (2000)PubMedCrossRefGoogle Scholar
  38. [38]
    Maj, M.C.; Singh, B.; Gupta, R.S.: Structure-activity studies on mammalian adenosine kinase. Biochem. Biophys. Res. Commun., 275, 386–393 (2000)PubMedCrossRefGoogle Scholar
  39. [39]
    Maj, M.; Singh, B.; Gupta, R.S.: The influence of inorganic phosphate on the activity of adenosine kinase. Biochim. Biophys. Acta, 1476, 33–42 (2000)PubMedGoogle Scholar
  40. [40]
    Cook, W.J.; DeLucas, L.J.; Chattopadhyay, D.: Crystal structure of adenosine kinase from Toxoplasma gondii at 1.8 A resolution. Protein Sci., 9, 704–712 (2000)PubMedCrossRefGoogle Scholar
  41. [41]
    Sinha, K.M.; Ghosh, M.; Das, I.; Datta, A.K.: Molecular cloning and expression of adenosine kinase from Leishmania donovani: identification of unconventional P-loop motif. Biochem. J., 339, 667–673 (1999)PubMedCrossRefGoogle Scholar
  42. [42]
    Mathews, I.I.; Erion, M.D.; Ealick, S.E.: Structure of human adenosine kinase at 1.5 Å resolution. Biochemistry, 37, 15607–15620 (1998)PubMedCrossRefGoogle Scholar
  43. [43]
    Xiao-Bing, L.V.; Hai-Zhen, W.U.; Jiang, Y.E.; Yi, F.; Hui-Zhan, Z.: Expression, purification and characterization of recombinant Saccharomyces cerevisiae adenosine kinase. Acta Biochim. Biophys. Sin., 35, 666–670 (2003)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Personalised recommendations