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Hypoxanthine phosphoribosyltransferase

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Class 2 · Transferases VI

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 33))

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References

  1. Flaks, J.G.: Nucleotide synthesis from 5-phosphoribosylpyrophosphate. Methods Enzymol., 6, 136–158 (1963)

    Article  CAS  Google Scholar 

  2. Lukens, L.N.; Herrington, K.A.: Enzymic formation of 6-mercaptopurine ribotide. Biochim. Biophys. Acta, 24, 432–433 (1957)

    Article  PubMed  CAS  Google Scholar 

  3. Nagy, M.; Ribet, A.-M.: Purification and comparative study of adenine and guanine phosphoribosyltransferases from Schizosaccharomyces pombe. Eur. J. Biochem., 77, 77–85 (1977)

    Article  PubMed  CAS  Google Scholar 

  4. Montero, C.; Llorente, P.: Artemia purine phosphoribosyltransferases. Purification and characterization. Biochem. J., 275, 327–334 (1991)

    PubMed  CAS  Google Scholar 

  5. Walter, R.D.; Koenigk, E.: Hypoxanthine-guanine phosphoribosyltransferase and adenine phosphoribosyltransferase from Plasmodium chabaudi, purification and properties. Tropenmed. Parasitol., 25, 227–235 (1974)

    PubMed  Google Scholar 

  6. Allen, T.; Henschel, E.V.; Coons, T.; Cross, L.; Conley, J.; Ullman, B.: Purification and characterization of the adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase activities from Leishmania donovani. Mol. Biochem. Parasitol., 33, 273–281 (1989)

    Article  PubMed  CAS  Google Scholar 

  7. Schimandle, C.M.; Mole, L.A.; Sherman, I.W.: Purification of hypoxanthine-guanine phosphoribosyltransferase of Plasmodium lophurae. Mol. Biochem. Parasitol., 23, 39–45 (1987)

    Article  PubMed  CAS  Google Scholar 

  8. Smithers, G.W.; O’Sullivan, W.J.: Hypoxanthine phosphoribosyltransferase from human brain: purification and partial characterization. Biochem. Med., 32, 106–121 (1984)

    Article  PubMed  CAS  Google Scholar 

  9. Olsen, A.S.; Milman, G.: Hypoxanthine phosphoribosyltransferase from Chinese hamster brain and human erythrocytes. Methods Enzymol., 51, 543–549 (1978)

    PubMed  CAS  Google Scholar 

  10. Hochstadt, J.: Hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase from enteric bacteria. Methods Enzymol., 51, 549–558 (1978)

    Article  PubMed  CAS  Google Scholar 

  11. Veres, G.; Monostori, E.; Rasko, I.: Purification and characterisation of chicken brain hypoxanthine-guanine phosphoribosyltransferase. FEBS Lett., 184, 299–303 (1985)

    Article  PubMed  CAS  Google Scholar 

  12. Ohe, T.; Watanabe, Y.: Purification and properties of hypoxanthine phosphoribosyltransferase from Streptomyces cyanogenus. Agric. Biol. Chem., 44, 1999–2006 (1980)

    CAS  Google Scholar 

  13. Schmidt, R.; Wiegand, H.; Reichert, U.: Purification and characterization of the hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Eur. J. Biochem., 93, 355–361 (1979)

    Article  PubMed  CAS  Google Scholar 

  14. Gutensohn, W.; Huber, M.; Jahn, H.: Facilitated purification of hypoxanthine phosphoribosyltransferase. Hoppe-Seyler’s Z. Physiol. Chem., 357, 1379–1385 (1976)

    PubMed  CAS  Google Scholar 

  15. Arnold, W.J.; Kelley, W.N.: Human hypoxanthine-guanine phosphoribosyltransferase. Purification and subunit structure. J. Biol. Chem., 246, 7398–7404 (1971)

    PubMed  CAS  Google Scholar 

  16. Olsen, A.S.; Milman, G.: Chinese hamster hypoxanthine-guanine phosphoribosyltransferase. Purification, structural, and catalytic properties. J. Biol. Chem., 249, 4030–4037 (1974)

    PubMed  CAS  Google Scholar 

  17. Hughes, S.H.; Wahl, G.M.; Capecchi, M.R.: Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. J. Biol. Chem., 250, 120–126 (1975)

    PubMed  CAS  Google Scholar 

  18. Olsen, A.S.; Milman, G.: Human hypoxanthine phosphoribosyltransferase. Purification and properties. Biochemistry, 16, 2501–2505 (1977)

    Article  PubMed  CAS  Google Scholar 

  19. Miller, R.L.; Ramsey, G.A.; Krenitsky, T.A.; Elion, G.B.: Guanine phosphoribosyltransferase from Escherichia coli, specificity and properties. Biochemistry, 11, 4723–4731 (1972)

    Article  PubMed  CAS  Google Scholar 

  20. Nussbaum, R.L.; Caskey, C.T.: Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry, 20, 4584–4590 (1981)

    Article  PubMed  CAS  Google Scholar 

  21. Dovey, H.F.; McKerrow, J.H.; Aldritt, S.M.; Wang, C.C.: Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy. J. Biol. Chem., 261, 944–948 (1986)

    PubMed  CAS  Google Scholar 

  22. Aldritt, S.M.; Wang, C.C.: Purification and characterization of guanine phosphoribosyltransferase from Giardia lamblia. J. Biol. Chem., 261, 8528–8533 (1986)

    PubMed  CAS  Google Scholar 

  23. Yuan, L.; Craig, S.P.; McKerrow, J.H.; Wang, C.C.: The hypoxanthine-guanine phosphoribosyltransferase of Schistosoma mansoni. Further characterization and gene expression in Escherichia coli. J. Biol. Chem., 265, 13528–13532 (1990)

    PubMed  CAS  Google Scholar 

  24. Muench, H.; Yoshida, A.: Purification and characterization of human hypoxanthine/guanine phosphoribosyltransferase. Eur. J. Biochem., 76, 107–112 (1977)

    Article  Google Scholar 

  25. Heroux, A.; White, E.L.; Ross, L.J.; Davis, R.L.; Borhani, D.W.: Crystal structure of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase with XMP, pyrophosphate, and two Mg2+ Ions Bound: insights into the catalytic mechanism. Biochemistry, 38, 14495–14506 (1999)

    Article  PubMed  CAS  Google Scholar 

  26. Heroux, A.; White, E.L.; Ross, L.J.; Borhani, D.W.: Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and-IMP complexes: comparison of purine binding interactions with the XMP complex. Biochemistry, 38, 14485–14494 (1999)

    Article  PubMed  CAS  Google Scholar 

  27. Jardim, A.; Ullman, B.: The conserved serine-tyrosine dipeptide in Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase is essential for catalytic activity. J. Biol. Chem., 272, 8967–8973 (1997)

    Article  PubMed  CAS  Google Scholar 

  28. Xu, Y.; Eads, J.; Sacchettini, J.C.; Grubmeyer, C.: Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry. Biochemistry, 36, 3700–3712 (1997)

    Article  PubMed  CAS  Google Scholar 

  29. Munagala, N.R.; Chin, M.S.; Wang, C.C.: Steady-state kinetics of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus: the role of threonine-47. Biochemistry, 37, 4045–4051 (1998)

    Article  PubMed  CAS  Google Scholar 

  30. Doyle, P.S.; Kanaani, J.; Wang, C.C.: Hypoxanthine, guanine, xanthine phosphoribosyltransferase activity in Cryptosporidium parvum. Exp. Parasitol., 89, 9–15 (1998)

    Article  PubMed  CAS  Google Scholar 

  31. Munagala, N.R.; Wang, C.C.: Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein. Biochemistry, 37, 16612–16619 (1998)

    Article  PubMed  CAS  Google Scholar 

  32. Shih, S.; Hwang, H.Y.; Carter, D.; Stenberg, P.; Ullman, B.: Localization and targeting of the Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase to the glycosome. J. Biol. Chem., 273, 1534–1541 (1998)

    Article  PubMed  CAS  Google Scholar 

  33. Keough, D.T.; Ng, A.-L.; Winzor, D.J.; Emmerson, B.T.; de Jersey, J.: Purification and characterization of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase and comparison with the human enzyme. Mol. Biochem. Parasitol., 98, 29–41 (1999)

    Article  PubMed  CAS  Google Scholar 

  34. Page, J.P.; Munagala, N.R.; Wang, C.C.: Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis. Eur. J. Biochem., 259, 565–571 (1999)

    Article  PubMed  CAS  Google Scholar 

  35. Sujay Subbayya, I.N.; Sukumaran, S.; Shivashankar, K.; Balaram, H.: Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes. Biochem. Biophys. Res. Commun., 272, 596–602 (2000)

    Article  PubMed  CAS  Google Scholar 

  36. Heroux, A.; White, E.L.; Ross, L.J.; Kuzin, A.P.; Borhani, D.W.: Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis. Structure Fold Des., 8, 1309–1318 (2000)

    Article  PubMed  CAS  Google Scholar 

  37. Wang, F.; Shi, W.; Nieves, E.; Angeletti, R.H.; Schramm, V.L.; Grubmeyer, C: A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase. Biochemistry, 40, 8043–8054 (2001)

    Article  PubMed  CAS  Google Scholar 

  38. Lee, C.C.; Medrano, F.J.; Craig, S.P., 3rd; Eakin, A.E.: Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase. Biochim. Biophys. Acta, 1537, 63–70 (2001)

    PubMed  CAS  Google Scholar 

  39. Monzani, P.S.; Alfonzo, J.D.; Simpson, L.; Oliva, G.; Thiemann, O.H.: Cloning, characterization and preliminary crystallographic analysis of Leishmania hypoxanthine-guanine phosphoribosyltransferase. Biochim. Biophys. Acta, 1598, 3–9 (2002)

    PubMed  CAS  Google Scholar 

  40. Micheli, V.; Gathof, B.S.; Rocchigiani, M.; Jacomelli, G.; Sestini, S.; Peruzzi, L.; Notarantonio, L.; Cerboni, B.; Hayek, G.; Pompucci, G.: Biochemical and molecular study of mentally retarded patient with partial deficiency of hypoxanthine-guanine phosphoribosyltransferase. Biochim. Biophys. Acta, 1587, 45–52 (2002)

    PubMed  CAS  Google Scholar 

  41. Sauve, A.A.; Cahill, S.M.; Zech, S.G.; Basso, L.A.; Lewandowicz, A.; Santos, D.S.; Grubmeyer, C.; Evans, G.B.; Furneaux, R.H.; Tyler, P.C.; McDermott, A.; Girvin, M.E.; Schramm, V.L.: Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases. Biochemistry, 42, 5694–5705 (2003)

    Article  PubMed  CAS  Google Scholar 

  42. Somoza, J.R.; Chin, M.S., Wang, C.C.; Fletterick, R.J.: Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus. Biochemistry, 35, 7032–7040 (1996)

    Article  PubMed  CAS  Google Scholar 

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(2007). Hypoxanthine phosphoribosyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 · Transferases VI. Springer Handbook of Enzymes, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49753-0_8

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