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Polymeric Nano Micelles as a Drug Carrier

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NanoScience in Biomedicine

Abstract

Over recent decades there has been increasing interest in developing drug delivery systems using polymeric micelles with nano size. Major challenges in drug delivery systems associated with nano micelles include achievement of a prolonged blood circulation and controlling appropriate drug release at target sites. The amphiphilic block copolymers show self-assembly behavior in aqueous media leading to micellar systems. Thus, the polymeric micelles formed in aqueous media from amphiphilic block copolymers are currently recognized as one of the most promising modalities of drug carriers. We will focus on the polymeric micelles as drug carrier. First, self-assembly of block copolymers in aqueous to form stable polymeric micelles will be discussed. The basic principles of self-assembly and micellization of block copolymers will be then given. Finally, we will concentrate on polymeric micelles, showing promise as long circulating carriers for drug delivery.

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Authors and Affiliations

  1. Fusion Biotechnology Research Center, Korea Research Institutes of Chemical Technology, Daejeon, 305-606, Korea

    Moon Suk Kim, Hyun Hoon & Hai Bang Lee

  2. BK-21 Polymer BIN Fusion Research Team, Chonbuk National University, Jeonju, 561-756, Korea

    Hyun Hoon & Gilson Khang

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  1. Moon Suk Kim
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  2. Hyun Hoon
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  3. Gilson Khang
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  4. Hai Bang Lee
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Correspondence to Moon Suk Kim .

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Editors and Affiliations

  1. Department of Chemical and Materials Engineering, College of Engineering, University of Cincinnati, Cincinnati, OH, 45221, USA

    Donglu Shi

  2. The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai, 200092, China

    Donglu Shi

  3. Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, 200240, China

    Donglu Shi

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Kim, M.S., Hoon, H., Khang, G., Lee, H.B. (2009). Polymeric Nano Micelles as a Drug Carrier. In: Shi, D. (eds) NanoScience in Biomedicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49661-8_16

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