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PET Chemistry pp 289–316Cite as

Synthesis Modules and Automation in F-18 Labeling

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Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 64))

Abstract

Fast implementation of PET into clinical studies and research has resulted in high demands in the automated modules for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. 18F-labeled radiotracers are of considerable interest due to longer half-life of fluorine-18 allowing remote site application, as demonstrated by [18F]FDG. In this chapter, the state of the art of commercially available modules for [18F]FDG is reviewed with the emphasis on multibatch production of this important radiotracer. Examples are given on the syntheses of other clinically relevant 18F-labeled radiotracers by using existing [18F]FDG synthesizers or with the help of general-purpose [18F]nucleophilic fluorination modules. On-going research and progress in the automation of complex radio labeling procedures followed by development of flexible multipurpose automated apparatus are discussed. The contribution of radiochemists in facilitating automation via introduction of new 18F-labeling techniques and labeling synthons, on-line reactions and purifications etc. is outlined.

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Authors and Affiliations

  1. Institute of the Human Brain, Russian Academy of Science, 9 Pavlov Str., 197376, St. Petersburg, Russia

    R. Krasikova

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  1. R. Krasikova
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Editors and Affiliations

  1. Animal Imaging Center — PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hönggerberg D-CHAB, Wolfgang-Pauli Str. 10, 8093, Zürich, Switzerland

    P. A. Schubiger

  2. Corporate Research, Schering AG, Müller Str. 178, 13342, Berlin, Germany

    L. Lehmann  & M. Friebe  & 

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Krasikova, R. (2007). Synthesis Modules and Automation in F-18 Labeling. In: Schubiger, P.A., Lehmann, L., Friebe, M. (eds) PET Chemistry. Ernst Schering Research Foundation Workshop, vol 64. Springer, Berlin, Heidelberg . https://doi.org/10.1007/978-3-540-49527-7_11

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  • DOI: https://doi.org/10.1007/978-3-540-49527-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-32623-6

  • Online ISBN: 978-3-540-49527-7

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