Abstract
Recombinant human activated protein C (rhAPC) has been demonstrated to reduce the mortality rate of adult patients with severe sepsis [1]. This effect is thought to be related to a reduction in coagulation and, to a lesser extent, to a reduction in the inflammatory response to sepsis. Data from the Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study demonstrated that the use of rhAPC was associated with a quicker reduction in cardiovascular failure.
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References
Bernard GR, Vincent JL, Laterre PF, et al (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699–709
Monnet X, Lamia B, Anguel N, Richard C, Bonmarchand G, Teboul JL (2005) Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients. Intensive Care Med 31:1573–1576
Kalil AC, Coyle SM, Um JY, et al (2004) Effects of drotrecogin alfa (activated) in human endotoxemia. Shock 21:222–229
Derhaschnig U, Reiter R, Knobl P, Baumgartner M, Keen P, Jilma B (2003) Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia. Blood 102:2093–2098
Isobe H, Okajima K, Uchiba M, et al (2001) Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide. Circulation 104:1171–1175
Favory R, Lancel S, Marechal X, Tissier S, Neviere R (2006) Cardiovascular protective role for activated protein C during endotoxemia in rats. Intensive Care Med 32:899–905
Sennoun S, Desebbe O, Barraud D, Gibot S, Levy B (2006) Hemodynamic effects of activated protein C. Intensive Care Med 32:S74 (abst)
Nick JA, Coldren CD, Geraci MW, et al (2004) Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood 104:3878–3885
Abraham E (2005) Effects of recombinant human activated protein C in human models of endotoxin administration. Proc Am Thorac Soc 2:243–247
Dahlback B, Villoutreix BO (2005) Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol 25:1311–1320
Macias WL, Yan SB, Williams MD, et al (2005) New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated). Crit Care 9(Suppl 4):S38–45
Dahlback B, Villoutreix BO (2005) The anticoagulant protein C pathway. FEBS Lett 579: 3310–3316
Mizutani A, Okajima K, Uchiba M, Noguchi T (2000) Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood 95: 3781–3787
Hoffmann JN, Vollmar B, Laschke MW, et al (2004) Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia. Crit Care Med 32:1011–1017
Uchiba M, Okajima K, Oike Y, et al (2004) Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res 95:34–41
Isobe H, Okajima K, Harada N, Liu W, Okabe H (2004) Activated protein C reduces stress-induced gastric mucosal injury in rats by inhibiting the endothelial cell injury. J Thromb Haemost 2:313–320
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Sennoun, N., Desebbe, O., Levy, B. (2007). Hemodynamic Effects of Activated Protein C in Septic Shock. In: Intensive Care Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49433-1_8
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DOI: https://doi.org/10.1007/978-3-540-49433-1_8
Publisher Name: Springer, Berlin, Heidelberg
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