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The Role of Vascular Endothelial Growth Factor in Lung Injury and Repair

  • Conference paper
Intensive Care Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2007))

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Abstract

Acute lung injury (ALI), along with its most severe form acute respiratory distress syndrome (ARDS), is one of the most challenging conditions in critical care medicine. ARDS continues to have a mortality of more than 35% despite improvements in ventilator strategies and management of sepsis [1]. Inflammation and increased vascular permeability are characteristics of ARDS. Vascular endothelial growth factor-A (VEGF-A) is a multi-functional cytokine known to play a pivotal role in angiogenesis and vascular permeability leading to interest in its potential role in ARDS. There is a body of work suggesting that VEGF plays a major role in lung development; however, it is expressed more highly in the healthy adult lung than any other organ suggesting a physiological role [2]. This apparent contradiction leads to controversy about the role of VEGF in ARDS.

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Authors and Affiliations

  1. Lung Research Group Department of Clinical Science at North Bristol, Southmead Hospital, Westbury on Trym, Bristol, BS10 5NB, UK

    J. Varet & A. B. Millar

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  1. J. Varet
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  2. A. B. Millar
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Varet, J., Millar, A.B. (2007). The Role of Vascular Endothelial Growth Factor in Lung Injury and Repair. In: Intensive Care Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49433-1_27

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  • DOI: https://doi.org/10.1007/978-3-540-49433-1_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-49432-4

  • Online ISBN: 978-3-540-49433-1

  • eBook Packages: MedicineMedicine (R0)

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