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The Impact of Chronic Disease on Response to Infection

  • Conference paper
Intensive Care Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2007))

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Abstract

Most patients with sepsis have underlying co-morbidities. Co-existing disease is typically thought to influence the pathophysiology and outcome of sepsis by reducing physiological reserve. Certainly this is true: A patient with chronic obstructive pulmonary disease (COPD) will tolerate pneumonia less well than a patient with previously healthy lungs. Additionally, many chronic disease states (or their treatments) alter the pre-existing inflammatory and immune milieu. This effect ranges from the obvious (as in the case of patients taking immunosuppressant therapy) to the underappreciated (as in the inflammatory dysregulation associated with obesity). In seeking explanations for differences in the host response to infection, much has been made of the possible effects of genetic variability. However, subtle variations in the underlying state of the immune and inflammatory systems have received little attention.

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Authors and Affiliations

  1. Department of Critical Care, University of Pittsburgh School of Medicine, 605 Scaife Hall 3550 Terrace Street, Pittsburgh, PA, 15261, USA

    M. C. Reade, E. B. Milbrandt & D. C. Angus

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  1. M. C. Reade
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  2. E. B. Milbrandt
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  3. D. C. Angus
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© 2007 Springer Science + Business Media Inc.

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Reade, M.C., Milbrandt, E.B., Angus, D.C. (2007). The Impact of Chronic Disease on Response to Infection. In: Intensive Care Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49433-1_18

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  • DOI: https://doi.org/10.1007/978-3-540-49433-1_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-49432-4

  • Online ISBN: 978-3-540-49433-1

  • eBook Packages: MedicineMedicine (R0)

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