Abstract
Almost 50,000,000 people in the world are estimated to have epilepsy, with a prevalence of 1–2 cases per 1000 persons in developed countries [20], and 18 per 1000 persons in developing ones [4]. While most epileptic patients can achieve seizure control with the use of antiepileptic drugs (AEDs), about 25–45% of them continue to have refractory seizures despite an appropriate clinical treatment [20, 26]. Medical refractoriness should be suspected when two appropriately chosen, well-tolerated, first-line AEDs or one monotherapy and one combination regimen have failed to achieve acceptable seizure control [5, 23].
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Inuzuka, M., Schimdt Brock, R., Dal ‘Col Lucio, J. (2008). Epilepsy Surgery. In: Samii's Essentials in Neurosurgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49250-4_32
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DOI: https://doi.org/10.1007/978-3-540-49250-4_32
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