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Prädiktive Pharmakologie und Toxikologie: Genetik, Genomik, Systembiologie

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Molekulare Pharmakologie und Toxikologie

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7 Prädiktive Pharmakologie und Toxikologie: Genetik, Genomik, Systembiologie

  • Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M, Numico G, Comino A, Attard M, Reelfs O, Gusterson B, Bell AK, Heath V, Tavassoli M, Farrell PJ, Smith P, Lu X, Crook T (2003) p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 3, 387–402.

    Article  PubMed  CAS  Google Scholar 

  • Bertilsson L (2001) Current Status: Pharmacogenetics/Drug Metabolism. In: Kalow W, Meyer UA, Tyndale RF. Pharmacogenomics. Dekker, New York Basel, pp 33–50

    Google Scholar 

  • Beutler E (1994) G6PD deficiency. Blood 84: 3613–3636

    PubMed  CAS  Google Scholar 

  • Beutler E, Vulliamy TJ (2002) Hematologically important mutations: glucose-6-phosphate dehydrogenase. Blood Cells Mol Dis 28: 93–103

    Article  PubMed  Google Scholar 

  • Blackstock WP, Weir MP (1999) Proteomics: quantitative and physical mapping of cellular proteins. Trends Biotechnol 17: 121–127

    Article  PubMed  CAS  Google Scholar 

  • Bleumink GS, Schut AF, Sturkenboom MC, Deckers JW, van Duijn CM, Stricker BH (2004) Genetic polymorphisms and heart failure. Genet Med 6:465–474

    Article  PubMed  CAS  Google Scholar 

  • Borlak J (2005) Handbook of toxicogenomics. Wiley-VCH, Weinheim

    Google Scholar 

  • Cascorbi I, Paul M, Kroemer HK (2004) Pharmacogenomics of heart failure — focus on drug disposition and action. Cardiovasc Res 64:32–39

    Article  PubMed  CAS  Google Scholar 

  • Cavalli-Sforza LL, Feldman MV (2003) The application of molecular genetic approaches to the study of human evolution. Nat Genet 33(Suppl): 266–275.

    Article  PubMed  CAS  Google Scholar 

  • Daly AK, Fairbrother KS, Smart J (1998) Recent advance in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes. Toxicol Lett 102–103: 143–147

    Article  PubMed  Google Scholar 

  • Efferth T, Volm M (2005). Pharmacogenetics for individualized cancer chemotherapy. Pharmacol Therapeutics 107:155–176

    Article  CAS  Google Scholar 

  • Efferth T, Bachli EB, Schwarzl SM, Goede JS, West C, Beutler E (2004) Glucose-6-phosphate dehydrogenase (G6PD) deficiency-type Zurich: a splice site mutation as an uncommon mechanism producing enzyme deficiency. Blood 104: 2608

    Article  PubMed  CAS  Google Scholar 

  • Efferth T, Sauerbrey A, Steinbach D, Gebhart E, Drexler HG, Miyachi H, Chitambar CR, Becker CM, Humeny A (2003) Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia. Int J Oncol 23: 509–517

    PubMed  CAS  Google Scholar 

  • Goedde HW, Agarwal DP (1992) Pharmacogenetics of aldehyde dehydrogenase. In: H Kalow, ed. Pharmacogenetics of drug metabolism. Pergamon, New York, pp 281–311

    Google Scholar 

  • Gonzalez FJ, Nebert DW (1990) Evolution of the P450 gene superfamily: animalplant ‘warfare’, molecular drive and human genetic differences in drug oxidation. Trends Genet 6: 182–186

    Article  PubMed  CAS  Google Scholar 

  • Gurubhagavatula S, Liu G, Park S, Zhou W, Su L, Wain JC, Lynch TJ, Neuberg S, Christiani DC (2004) XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy. J Clin Oncol 22: 2594–2601

    Article  PubMed  CAS  Google Scholar 

  • Harper PA, Wong JY, Lam MS, Okey AB (2002) Polymorphisms in the human AH receptor. Chem Biol Interact 141: 161–187

    Article  PubMed  CAS  Google Scholar 

  • Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE, Jurutka PW (1998) The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 13: 325–349

    Article  PubMed  CAS  Google Scholar 

  • Kalow W (2001) Interethnic differences in Drug Response. In: Kalow W, Meyer UA, Tyndale RF. Pharmacogenomics. Dekker, New York Basel, pp 109–134

    Google Scholar 

  • Kalow W and Bertilsson L (1994) Interethnic factors affecting drug response. Adv Drug Res 25: 1–59

    CAS  Google Scholar 

  • Kebarle P, Tang L (1993) From ions in solution to ions in the gas phase — the mechanism of electrospray mass spectrometry. Anal Chem 65: 972A–986A

    CAS  Google Scholar 

  • Kim RB (2002) MDR1 single nucleotide polymorphisms: multiplicity of haplotypes and functional consequences. Pharmacogenetics 12: 425–427

    Article  PubMed  CAS  Google Scholar 

  • Marez D, Legrand M, Sabbagh N, Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F (1997) Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics 7: 193–202

    Article  PubMed  CAS  Google Scholar 

  • Marsh S, Kwok P, McLeod HL (2002) SNP databases and pharmacogenetics: great start, but a long way to go. Hum Mutat 20: 174–179

    Article  PubMed  CAS  Google Scholar 

  • Marsh S, McLeod HL (2004) Cancer pharmacogenetics. Br J Cancer 90, 8–11

    Article  PubMed  CAS  Google Scholar 

  • Montano MM, Ekena K, Keller AL, Katzenellenbogen BS (1996) Human estrogen receptor ligand activity inversion mutants: receptors that interpret antiestrogens as estrogens and estrogens as antiestrogens and discriminate among different antiestrogens. Mol Endocrinol 10: 230–242

    Article  PubMed  CAS  Google Scholar 

  • Oscarson M (2003) Pharmacogenetics of drug metabolising enzymes: importance for personalised medicine. Clin Chem Lab Med 41: 573–580.

    Article  PubMed  CAS  Google Scholar 

  • Pasterkamp G, Van Keulen JK, De Kleijn DP (2004) Role of Toll-like receptor 4 in the initiation and progression of atherosclerotic disease. Eur J Clin Invest 34: 328–334

    Article  PubMed  CAS  Google Scholar 

  • Priori SG, Barhanin J, Hauer RN, Haverkamp W, Jongsma HJ, Kleber AG, McKenna WJ, Roden DM, Rudy Y, Schwartz K, Schwartz PJ, Towbin JA, Wilde AM (1999) Genetic and molecular basis of cardiac arrhythmias: impact on clinical management part III. Circulation 99: 674–681

    PubMed  CAS  Google Scholar 

  • Ryu JS, Hong YC, Han HS, Lee JE, Kim S, Park YM, Kim YC, Hwang TS (2004) Association between polymorphisms of ERCC1 and XPD and survival in nonsmall-cell lung cancer patients treated with cisplatin combination chemotherapy. Lung Cancer 44: 311–316.

    Article  PubMed  Google Scholar 

  • Sakaeda T, Nakamura T, Okumura K (2003) Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs. Pharmacogenomics 4: 397–410

    Article  PubMed  CAS  Google Scholar 

  • Schelleman H, Stricker BH, De Boer A, Kroon AA, Verschuren MW, Van Duijn CM, Psaty BM, Klungel OH (2004) Drug-gene interactions between genetic polymorphisms and antihypertensive therapy. Drugs 64: 1801–1816

    Article  PubMed  CAS  Google Scholar 

  • Schwab M, Eichelbaum M, Fromm MF (2003) Genetic polymorphism of the human MDR1 drug transporter. Annu Rev Pharmacol Toxicol 43: 285–307

    Article  PubMed  CAS  Google Scholar 

  • Schwarzl SM, Smith JC, Kaina B, Efferth T (2005) Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms. Int J Mol Med 16:553–557

    PubMed  CAS  Google Scholar 

  • Ujike H, Morita Y (2004) New perspectives in the studies on endocannabinoid and cannabis: cannabinoid receptors and schizophrenia. J Pharmacol Sci 96: 376–381

    Article  PubMed  CAS  Google Scholar 

  • Ulrich CM, Robien K, McLeod HL (2003) Cancer pharmacogenetics: polymorphisms, pathways and beyond. Nat Rev Cancer 3: 912–920

    Article  PubMed  CAS  Google Scholar 

  • Vink A, de Kleijn DP, Pasterkamp G (2004) Functional role for toll-like receptors in atherosclerosis and arterial remodeling. Curr Opin Lipidol 15: 515–521

    Article  PubMed  CAS  Google Scholar 

  • Watters JW, Kraja A, Meucci MA, Province MA, McLeod HL (2004) Genomewide discovery of loci influencing chemotherapy cytotoxicity. Proc Natl Acad Sci USA 101: 11809–11814

    Article  PubMed  CAS  Google Scholar 

  • Weber WW. Pharmacogenetics — Receptors (2001) In: Kalow W, Meyer UA, Tyndale RF. Pharmacogenomics. Dekker, New York Basel, pp 51–80

    Google Scholar 

  • Weir TD, Mallek N, Sandford AJ, Bai TR, Awadh N, Fitzgerald JM, Cockcroft D, James A, Liggett SB, Pare PD (1992) β2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. Am J Respir Crit Care Med 158: 787–791

    Google Scholar 

  • Whitfield JN (1997) Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. Alcohol Alcohol 32: 613–619

    PubMed  CAS  Google Scholar 

  • Zareba W, Moss AJ, Schwartz PJ, Vincent GM, Robinson JL, Priori SG, Benhorin J, Locati EH, Towbin JA, Keating MT, Lehmann MH, Hall WJ (1998) Influence of genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. N Engl J Med 339: 960–965

    Article  PubMed  CAS  Google Scholar 

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(2006). Prädiktive Pharmakologie und Toxikologie: Genetik, Genomik, Systembiologie. In: Molekulare Pharmakologie und Toxikologie. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48245-1_7

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