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Current Issues Concerning the Role of Oxidative Stress in Aging: A Perspective

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The Molecular Genetics of Aging

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 29))

Summary

The main tenet of the oxidative stress hypothesis of aging is that accrual of molecular oxidative damage is the principal causal factor in the senescence-related loss of ability to maintain homeostasis. This hypothesis has garnered a considerable amount of supportive correlational evidence, which is now being extended experimentally in transgenic Drosophila overexpressing antioxidative defense enzymes. Some of these studies have reported extensions of life span, while others have not. Interpretation of life spans in poikilotherms is complicated by a number of factors, including the interrelationship between metabolic rate and longevity. The life spans of poikilotherms can be extended multifold by reducing the metabolic rate but without affecting the metabolic potential, i.e., the total amount of energy expended during life. A hypometabolic state in poikilotherms also enhances stress resistance and activities of antioxidative enzymes. It is emphasized that extension of life span without simultaneously increasing metabolic potential is of questionable biological significance.

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Authors and Affiliations

  1. Department of Biological Sciences, Southern Methodist University, Dallas, TX, 75275, USA

    Rajindar S. Sohal, Robin J. Mockett & William C. Orr

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  1. Rajindar S. Sohal
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  2. Robin J. Mockett
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  1. Department of Biology, McGill University, 1205 Ave. Docteur Penfield, H3A 1B1, Montréal, Quebec, Canada

    Siegfried Hekimi

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Sohal, R.S., Mockett, R.J., Orr, W.C. (2000). Current Issues Concerning the Role of Oxidative Stress in Aging: A Perspective. In: Hekimi, S. (eds) The Molecular Genetics of Aging. Results and Problems in Cell Differentiation, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48003-7_3

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