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Antibiotic Bone Cement as a Prophylactic Means in Joint Replacement Surgery

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Abstract

The use of some form of cement as an alternative to direct mechanical fixation (press-fit, screws etc) dates back to the earliest period of joint replacement surgery. The first void-filling agent to be tried by Gluck in 1890 was a combination of plaster, pumice and resin. At this time there were no antibiotics, and the experiments failed for this and other obvious reasons [13]. When methyl methacrylate as a bone cement was made popular in the field of implant fixation in the 1960’s, antibiotics were available and the first documented use of antibiotic loaded bone cement occurred within this decade [4].

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References

  1. Adalberth G, Nilsson KG, Karrholm J et al (2002) Fixation of the tibial component using CMW-1 or Palacos bone cement with gentamicin: similar outcome in a randomized radiostereometric study of 51 total knee arthroplasties. Acta Orthop Scand 73(5):531–538

    Article  PubMed  Google Scholar 

  2. Armstrong M, Spencer RF, Lovering AM et al (2002) Antibiotic elution from bone cement: A study of common cement-antibiotic combinations. Hip International (12):23–27

    Google Scholar 

  3. van de Belt H, Neut D, Schenk W et al (2000) Gentamicin release from polymethylmethylacrylate bone cement and staphylococcus aureus biofilm formation. Acta Orthop Scand 71(6):625–629

    Article  PubMed  Google Scholar 

  4. Buchholz HW, Elson RA, Engelbrecht E et al (1981) Management of deep infection of total hip replacement. J Bone Joint Surg (Br) 63(3):342–353

    Google Scholar 

  5. Chiu FY, Lin C-FJ, Chen CM et al (2001) Cefuroxime-impregnated cement at primary total knee arthroplasty in diabetes mellitus. A prospective, randomized study. J Bone Joint Surg (Br) 83(5):691–695

    Article  CAS  Google Scholar 

  6. Chiu FY, Chen CM, Lin C-FJ et al (2002). Cefuroxime-impregnated cement in primary total knee arthroplasty: a prospective, randomized study of three hundred and forty knees. J Bone Joint Surg (Am) 84(5):759–762

    PubMed  Google Scholar 

  7. Davies J, O’Connor DO, Harris WH (1984). Comparison of the mechanical properties of Palacos, Palacos-gentamicin and Simplex P. Orthop Trans (8):400–401

    Google Scholar 

  8. Espehaug B, Engesaeter LB, Vollset SE et al (1997). Antibiotic prophylaxis in total hip arthroplasty. Review of 10,905 primary cemented total hip replacements reported to the Norwegian arthroplasty register, 1987 to 1995. J Bone Joint Surg (Br) 79(4):590–595

    Article  CAS  Google Scholar 

  9. Fletcher MDA, Spencer RF, Langkamer VG et al (2004). Gentamicin concentrations in diagnostic aspirates from 25 patients with hip and knee arthroplasties. Acta Orthop Scand 75(2):173–176

    Article  PubMed  Google Scholar 

  10. Forsythe ME, Crawford S, Sterling GJ et al (2006). Safeness of Simplex-tobramycin bone cement in patients with renal dysfunction undergoing total hip replacement. J Orthop Surg 14(1):38–42

    CAS  Google Scholar 

  11. Hansen AD (2004). Prophylactic use of antibiotic bone cement: an emerging standard — in opposition. J Arthroplasty 19(suppl 1):73–77

    Article  Google Scholar 

  12. Josefsson G, Kolmert L (1993). Prophylaxis with systematic antibiotics versus gentamicin bone cement in total hip arthroplasty: A ten-year survey of 1,688 hips. Clin Orthop Relat Res (292):210–214

    PubMed  Google Scholar 

  13. LeVay D (1990). The history of orthopaedics. Parthenon, Carnforth

    Google Scholar 

  14. Lewis G, Bhattaram A (2006). Influence of a pre-blended antibiotic (gentamicin sulfate powder) on various mechanical, thermal and physical properties of three acrylic bone cements. J Biomater Appl 20(4):377–408

    Article  PubMed  CAS  Google Scholar 

  15. Malchau H, Herberts P, Ahnfelt L (1993). Prognosis of total hip replacement in Sweden. Follow-up of 92,675 operations performed 1978–1990. Acta Orthop Scand 64(5):497–506

    Article  PubMed  CAS  Google Scholar 

  16. Masri BA, Duncan CP, Beauchamp CP (1998). Long-term elution of antibiotics from bone cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplasty 13(3):331–338

    Article  PubMed  CAS  Google Scholar 

  17. Neut D, Hendriks JGE, van Horn JR et al (2006). Antimicrobial efficacy of gentamicin-loaded acrylic bone cements with fusidic acid or clindamycin added. J Orthop Res 24(2):291–299

    Article  PubMed  CAS  Google Scholar 

  18. Penner MJ, Duncan CP, Masri BA (1999). The in vitro elution characteristics of antibiotic-loaded CMW and Palacos-R bone cements. J Arthroplasty 14(2):209–214

    Article  PubMed  CAS  Google Scholar 

  19. Powles JW, Spencer RF, Lovering AM (1998). Gentamicin release from old cement during revision hip arthroplasty. J Bone Joint Surg (Br) 80(4):607–610

    Article  CAS  Google Scholar 

  20. Thornes B, Murray P, Bouchier-Hayes D (2002) Development of resistant strains of staphylococcus epidermidis on gentamicin loaded bone cement in vivo. J Bone Joint Surg (Br) 84(5):758–760

    Article  Google Scholar 

  21. Trippel SB (1986) Antibiotic impregnated cement in total joint arthroplasty. J Bone Joint Surg (Am) 68(8):1297–1302

    PubMed  CAS  Google Scholar 

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© 2007 Springer-Verlag Berlin Heidelberg

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Lundberg, A., Hedlund, H. (2007). Antibiotic Bone Cement as a Prophylactic Means in Joint Replacement Surgery. In: Meani, E., Romanò, C., Crosby, L., Hofmann, G., Calonego, G. (eds) Infection and Local Treatment in Orthopedic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47999-4_8

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  • DOI: https://doi.org/10.1007/978-3-540-47999-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-47998-7

  • Online ISBN: 978-3-540-47999-4

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