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Rationale of Nail Antibiotic Clothing and “in vivo” Animal Study

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Infection and Local Treatment in Orthopedic Surgery

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Abstract

Osteomyelitis is a severe complication of both fracture osteosynthesis and joint replacement surgery [2, 5, 30, 33]. While healthy bone is very resistant to infections, and bacteria alone will not necessarily cause osteomyelitis, other factors such as vascular stasis, soft tissue injuries, fracture instability and the presence of foreign materials are important pathogenetic factors [9]. Fracture instability, caused by inappropriate repair techniques or by implant failure, allows ongoing interfragmentary motion which impairs vascularization and promotes bone necrosis [9]. Fixation devices and prostheses may assist the bacterial colonization, because bacteria produce a mucoid polysaccharide biofilm which binds them to bone and metallic implants and protects them from host defences such as phagocytes and antibodies [2, 9]. Postoperative osteomyelitis is ususally treated by removal of the infected implanted device, surgical debridement of the implant bed and reimplantation of a new device [5, 25]. Antibiotic therapy is also necessary for a successful treatment [5, 25].

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Authors and Affiliations

  1. Department of Experimental Surgery, Rizzoli Orthopaedic Institutes, Bologna, Italy

    R. Giardino, M. Fini & G. Giavaresi

  2. DMCSS - Microbiology, St. Orsola Hospital, University of Bologna, Bologna, Italy

    V. Sambri

  3. Department of Orthopaedic Surgery C.O.S., “G.Pini” Orthopaedic Institute, Milan, Italy

    C. Romanò & E. Meani

  4. Research & Development, Tecres Spa, Sommacampagna, Verona, Italy

    R. Soffiatti

Authors
  1. R. Giardino
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  2. M. Fini
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  3. G. Giavaresi
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  4. V. Sambri
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  5. C. Romanò
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  6. E. Meani
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Editors and Affiliations

  1. Istituto Ortopedico G. Pini Centro per il Trattamento delle Complicanze, Ortopediche Settiche (COS), Piazza Cardinal Ferrari 1, 20122, Milano, Italy

    Enzo Meani MD  & Carlo Romanò MD  & 

  2. Department of Orthopaedic Surgery, 30 East Apple Street, Dayton, Ohio, 45409, USA

    Lynn Crosby MD

  3. Department of Traumatology, BG-Klinikum Bergmannstrost Halle, Merseburger Straße 165, 06112, Halle a. d. Saale, Germany

    Gunther Hofmann MD

  4. Tecres S.p.A., Via A. Doria, 6, 37066, Sommacampagna/VR, Italy

    Giovanni Calonego (Scientific Coordinator) (Scientific Coordinator)

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© 2007 Springer-Verlag Berlin Heidelberg

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Giardino, R. et al. (2007). Rationale of Nail Antibiotic Clothing and “in vivo” Animal Study. In: Meani, E., Romanò, C., Crosby, L., Hofmann, G., Calonego, G. (eds) Infection and Local Treatment in Orthopedic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47999-4_42

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  • DOI: https://doi.org/10.1007/978-3-540-47999-4_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-47998-7

  • Online ISBN: 978-3-540-47999-4

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