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PMMA as Drug Delivery System and in vivo Release from Spacers

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Infection and Local Treatment in Orthopedic Surgery

Abstract

Infection is the most serious complication following orthopaedic surgery. The frequency is low, but when present is difficult to treat. Systemic drug administration may not provide inhibitory concentration for a prolonged period, and this is further worsened by the decreased blood supply. The local delivery of antibiotics to the surgical area may may contribute to reduce the infection frequency and the risk of recolonization [16].

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Authors and Affiliations

  1. Department of Medicine and Public Health, Pharmacology Section, University of Verona, Verona

    E. Bertazzoni Minelli & A. Benini

Authors
  1. E. Bertazzoni Minelli
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  2. A. Benini
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Editor information

Editors and Affiliations

  1. Istituto Ortopedico G. Pini Centro per il Trattamento delle Complicanze, Ortopediche Settiche (COS), Piazza Cardinal Ferrari 1, 20122, Milano, Italy

    Enzo Meani MD  & Carlo Romanò MD  & 

  2. Department of Orthopaedic Surgery, 30 East Apple Street, Dayton, Ohio, 45409, USA

    Lynn Crosby MD

  3. Department of Traumatology, BG-Klinikum Bergmannstrost Halle, Merseburger Straße 165, 06112, Halle a. d. Saale, Germany

    Gunther Hofmann MD

  4. Tecres S.p.A., Via A. Doria, 6, 37066, Sommacampagna/VR, Italy

    Giovanni Calonego (Scientific Coordinator) (Scientific Coordinator)

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© 2007 Springer-Verlag Berlin Heidelberg

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Minelli, E.B., Benini, A. (2007). PMMA as Drug Delivery System and in vivo Release from Spacers. In: Meani, E., Romanò, C., Crosby, L., Hofmann, G., Calonego, G. (eds) Infection and Local Treatment in Orthopedic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47999-4_11

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  • DOI: https://doi.org/10.1007/978-3-540-47999-4_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-47998-7

  • Online ISBN: 978-3-540-47999-4

  • eBook Packages: MedicineMedicine (R0)

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