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Genomic Imprinting in Mammals

Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 18)

Abstract

This is a good time to write a general article on imprinting. In the last 5 years or so imprinting has progressed from an intriguing embryological observation to a firmly established biological principle with far-reaching consequences for mammalian development, genetics, and human disease. We now know why parthenogenesis in some mammals is not possible. We know of some imprinted genes and we even know what they do. We know that disomy can cause disease in humans. We know of genetic phenomena that extend classical Mendelian concepts. And we are gaining knowledge of the molecular mechanism of imprinting, knowledge that makes us believe that imprinting-like epigenetic controls guide differentiation in all multicellular organisms.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  1. 1.Department of Molecular EmbryologyInstitute of Animal Physiology and Genetics ResearchBabraham, CambridgeUK

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