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Genomic Imprinting in Mammals

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Early Embryonic Development of Animals

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 18))

Abstract

This is a good time to write a general article on imprinting. In the last 5 years or so imprinting has progressed from an intriguing embryological observation to a firmly established biological principle with far-reaching consequences for mammalian development, genetics, and human disease. We now know why parthenogenesis in some mammals is not possible. We know of some imprinted genes and we even know what they do. We know that disomy can cause disease in humans. We know of genetic phenomena that extend classical Mendelian concepts. And we are gaining knowledge of the molecular mechanism of imprinting, knowledge that makes us believe that imprinting-like epigenetic controls guide differentiation in all multicellular organisms.

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Authors and Affiliations

  1. Department of Molecular Embryology, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, CB2 4AT, UK

    Wolf Reik

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  1. Wolf Reik
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  1. Dept. of Molecular and Developmental Genetics, University of Nijmegen, NL-6525 ED, Toernooiveld, Nijmegen, The Netherlands

    Wolfgang Hennig

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© 1992 Springer-Verlag Berlin Heidelberg

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Reik, W. (1992). Genomic Imprinting in Mammals. In: Hennig, W. (eds) Early Embryonic Development of Animals. Results and Problems in Cell Differentiation, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47191-2_5

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  • DOI: https://doi.org/10.1007/978-3-540-47191-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21836-5

  • Online ISBN: 978-3-540-47191-2

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