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Early Mouse Development

Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 18)

Abstract

The mouse is well established as the experimental mammal for developmental and genetic studies. The large interest in mouse development and genetics is founded in our curiosity about human embryonic development and in our interest in understanding genetic diseases perturbing normal embryogenesis. The use of mice (as a mammalian model) is favoured due to their easy maintenance and handling as well as their relatively short generation time.

Keywords

Zona Pellucida Recombinant Inbred Inner Cell Mass Primitive Streak Primitive Endoderm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adamson ED (1982) The location and synthesis of transferrin in mouse embryos and teratocarcinoma cells. Dev Biol 91: 227–234PubMedCrossRefGoogle Scholar
  2. Akam M (1989) Hox and HOM: homologous gene clusters in insects and vertebrates. Cell 57: 347–349PubMedCrossRefGoogle Scholar
  3. Allen ND, Cran DG, Barton SC, Hettle S, Reik W, Surani A (1988) Transgenes as probes for active chromosomal domains in mouse development. Nature 333: 852–855PubMedCrossRefGoogle Scholar
  4. Babinet C, Morello D, Renard JP (1989) Transgenic mice. Genome 31: 938–949PubMedCrossRefGoogle Scholar
  5. Bachvarova R, DeLeon V (1980) Polyadenylated RNA of mouse ova and loss of maternal RNA in early development. Dev Biol 74: 1–8PubMedCrossRefGoogle Scholar
  6. Bailey DW (1971) Recombinant inbred strains, an aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation 11: 325–327PubMedCrossRefGoogle Scholar
  7. Balling R, Deutsch U, Gruss P (1988) undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paried box of Pax 1. Cell 55: 531–535Google Scholar
  8. Beddington RSP (1981) An autoradiographic analysis of the potency of embryonic ectoderm in the 8th day postimplantation mouse embryo. J Embryol Exp Morphol 64: 87–104PubMedGoogle Scholar
  9. Beddington RSP (1982) An autoradiographic analysis of tissue potency of different regions of embryonic ectoderm during gastrulation in the mouse embryo. J Embryol Exp Morphol 69: 265–285PubMedGoogle Scholar
  10. Beddington RSP (1983a) The origin of fetal tissues during gastrulation in the rodent. In: Johnson MH (ed) Development in mammals, vol 5. Elsevier, Amsterdam, pp 1–32Google Scholar
  11. Beddington RSP (1983b) Histogenic and neoplastic potential of different regions of the embryonic egg cylinder. J Embryol Exp Morphol 75: 189–204PubMedGoogle Scholar
  12. Bellen HJ, O’Kane CJ, Wilson C, Grossniklaus U, Pearson RK, Gehring WJ (1989) P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev 3: 1288–1300PubMedCrossRefGoogle Scholar
  13. Bellvé AR, O’Brien DA (1983) The mammalian spermatozoon: structure and temporal assembly. In: Hartmann JF (ed) Mechanism and control of animal fertilization. Academic Press, London, pp 55–137Google Scholar
  14. Bennett D (1975) The t-locus of the mouse. Cell 6: 441–454CrossRefGoogle Scholar
  15. Bleil JD, Wassarman PM (1980a) Structure and function of the zona pellucida: identification and characterization of the mouse oocyte zona pellucida. Dev Biol 76: 185–202PubMedCrossRefGoogle Scholar
  16. Bleil JD, Wassarman PM (1980b) Synthesis of zona pellucida proteins by denuded and follicle-enclosed mouse oocytes during culture in vitro. Proc Natl Acad Sci USA 77: 1029–1033PubMedCrossRefGoogle Scholar
  17. Bleil JD, Wassarman PM (1980c) Mammalian sperm and egg interaction: identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm. Cell 20: 773–882CrossRefGoogle Scholar
  18. Bonhomme F, Guénet J-L (1989) The wild house mouse and its relatives. In: Lyon MF, Searle AG (eds) Genetic variants and strains of the laboratory mouse. Oxford University Press, Oxford, pp 649–662Google Scholar
  19. Bonhomme F, Guénet J-L, Dod B, Moriwaki K, Bulfield G (1987) The phylogenetic origin of laboratory inbred mice and their rate of evolution. Biol J Linn Soc Lond 30: 51–58CrossRefGoogle Scholar
  20. Bopp D, Burri M, Baumgartner S, Frierio G, Noll M (1986) Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila. Cell 47: 1033–1040PubMedCrossRefGoogle Scholar
  21. Bradley A, Evans M, Kaufman MH, Robertson E (1984) Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309: 255–256PubMedCrossRefGoogle Scholar
  22. Braude P, Pelham H, Flach G, Lobatto R (1979) Post-transcriptional control in the early mouse embryo. Nature 282: 102–105PubMedCrossRefGoogle Scholar
  23. Breitman ML, Clapoff S, Rossant J, Tsui LC, Glode LM, Maxwell IH, Bernstein A (1987) Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science 238: 1563–1565PubMedCrossRefGoogle Scholar
  24. Breitman ML, Rombola H, Maxwell IH, Klintworth GK, Bernstein A (1990) Genetic ablation in transgenic mice with an attenuated diphteria toxin A gene. Mol Cell Biol 10: 474–479PubMedGoogle Scholar
  25. Brinster RL, Chen HY, Trumbauer ME, Senear AW, Warren R, Palmiter RD (1981) Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27: 223–231PubMedCrossRefGoogle Scholar
  26. Brinster RL, Chen HY, Trumbauer ME, Yagle MK, Palmiter RD (1985) Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci USA 82: 4438–4442PubMedCrossRefGoogle Scholar
  27. Brinster RL, Chen HY, Warren R, Sarthy A, Palmiter RD (1982) Regulation of metallotheionein-thymidine kinase fusion plasmids injected into mouse eggs. Nature 296: 39–42PubMedCrossRefGoogle Scholar
  28. Capecchi M (1989a) The new mouse genetics: altering the genome by gene targeting. TIG 5: 70–76PubMedCrossRefGoogle Scholar
  29. Capecchi M (1989b) Altering the genome by homologous recombination. Science 244: 1288–1292PubMedCrossRefGoogle Scholar
  30. Carlin B, Jaffe R, Bender B, Chung AE (1981) Entactin, a novel basal lamina associated sulfated glycoprotein. J Biol Chem 256: 5209–5214PubMedGoogle Scholar
  31. Carter TC, Lyon MF, Phillips RJS (1955) Gene-tagged chromosome translocations in eleven stocks of mice. J Genet 53: 154–166CrossRefGoogle Scholar
  32. Carter TC, Lyon MF, Phillips RJS (1956) Further genetic studies of eleven translocations in the mouse. J Genet 54: 462–473CrossRefGoogle Scholar
  33. Cascio S, Wassarman PM (1982) Prograsm of early development in the mammal: post-transcriptional control of a class of proteins synthesized by mouse oocytes and early embryos. Dev Biol 89: 397–408PubMedCrossRefGoogle Scholar
  34. Caspersson T, Farber S, Foley GE, Kudynowski J, Modest EJ, Simonsson E, Wagh U, Zech L (1968) Chemical differentiation along metaphase chromosomes. Exp Cell Res 49: 219–222PubMedCrossRefGoogle Scholar
  35. Castle WE (1903) Mendel’s law of heredity. Proc Am Acad Arts Sci 38: 535–548CrossRefGoogle Scholar
  36. Cattanach BM (1974) Position effect variegation in the mouse. Genet Res Camb 23: 291–306CrossRefGoogle Scholar
  37. Cattanach BM (1975) Control of chromosome inactivation. Annu Rev Genet 9: 1–18PubMedCrossRefGoogle Scholar
  38. Chabot B, Stevenson DA, Chapman VM, Besmer P, Bernstein A (1988) The proto-oncogene c-kit encoding a transmembrane tyrosine receptor maps to the mouse W locus. Nature 353: 88–89CrossRefGoogle Scholar
  39. Chiquoine AD (1954) The identification, origin and migration of the primordial germ cells of the mouse embryo. Anat Rec 118: 135–146PubMedCrossRefGoogle Scholar
  40. Chisaka O, Capecchi MR (1991) Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene Hox 1.5. Nature 350: 473–479PubMedCrossRefGoogle Scholar
  41. Chowdhury K, Deutsch U, Gruss P (1987) A multigene family encoding several “finger” structures is present and differentially active in mammalian genomes. Cell 48: 771–778PubMedCrossRefGoogle Scholar
  42. Clark CC, Crossland J, Kaplan G, Martinez-Hernandez A (1982) Location and identification of the collagen found in the 14.5 day rat embryo visceral yolk sac. J Cell Biol 93: 251–260PubMedCrossRefGoogle Scholar
  43. Clegg KB, Piko L (1977) Size and specific activity of the UTP pool and overall rates of RNA synthesis in early mouse embryos. Dev Biol 58: 76–95PubMedCrossRefGoogle Scholar
  44. Clegg KB, Piko L (1983) Quantitative aspects of RNA synthesis and polyadenylation in 1-cell and 2-cell mouse embryo. J Embryol Exp Morphol 74: 169–182PubMedGoogle Scholar
  45. Cockroft DL (1986) Regional and temporal differences in the parietal endoderm of the midgestation mouse embryo. J Anat 145: 35–47PubMedGoogle Scholar
  46. Constantini F, Lacy E (1981) Introduction of a rabbit globin gene into the mouse germ line. Nature 294: 92–94CrossRefGoogle Scholar
  47. Constantini F, Radice G, Lee JJ, Chada KK, Perry W, Jin Son H (1989) Insertional mutations in transgenic mice. Prog Nucleic Acid Res 36: 159–169CrossRefGoogle Scholar
  48. Copeland NG, Jenkins NA (1991) Development and applications of a molecular genetic linkage map of the mouse genome. TIG 7 (4): 113–118PubMedCrossRefGoogle Scholar
  49. Copp AJ, Roberts HM, Polani PE (1986) Chimaerism of primordial germ cells in the early postimplantation mouse embryo following microsurgical grafting of posterior primitive streak cells in vitro. J Embryol Exp Morphol 95: 95–115PubMedGoogle Scholar
  50. Copp AJ, Cockroft DL (eds) (1990) Postimplantation mammalian embryos: a practical approach. IRL Press, OxfordGoogle Scholar
  51. Cruz YP, Pedersen RA (1985) Cell fate in the polar trophectoderm of mouse blastocysts as studied by microinjection of cell lineage tracers. Dev Biol 112: 73–83PubMedCrossRefGoogle Scholar
  52. Cullen B, Emigholz K, Monohan J (1980) The transient appearance of specific proteins in one-cell embryos. Dev Biol 76: 215–221PubMedCrossRefGoogle Scholar
  53. Davisson MT, Roderick TH (1976) Cytology of inversions in mice. Genetics 83: s19Google Scholar
  54. Deutsch U, Dressler GR, Gruss P (1988) Pax 1, a member of a paired box homologous murine gene family is expressed in segmented structures during development. Cell 53: 617–625Google Scholar
  55. Doetschman TC, Eistetter H, Katz M, Schmidt W, Kemler R (1985) The in vitro development of blastocyst derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 87: 27–45PubMedGoogle Scholar
  56. Doetschman T, Gregg RG, Maeda N, Hooper ML, Melton DW, Thompson S, Smithies O (1987) Targeted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 330: 576–578PubMedCrossRefGoogle Scholar
  57. Donovan PJ, Stott D, Cairns LA, Heasman J, Wylie CC (1986) Migratory and postmigratory mouse primordial germ cells behave differently in culture. Cell 44:831–838Google Scholar
  58. Dove WF (1987) Molecular genetics of Mus musculus: point mutagenesis and millimorgans. Genetics 116: 5–8PubMedGoogle Scholar
  59. Dressler GR, Deutsch U, Balling R, Simon D, Guenét JL, Gruss P (1988) Murine genes with homology to Drosophila segmentation genes. Development 104 (Suppl): 181–186Google Scholar
  60. Dressler GR, Deutsch U, Chowdhury K, Nornes HO, Gruss P (1990) Pax 2, a new murine paried-box-containing gene and its expression in the developing excretory system. Development 109: 787–795Google Scholar
  61. Ducibella T, Anderson E (1975) Cell shape and membrane changes in the eight-cell mouse embryo: prerequisites for morphogenesis of the blastocyst. Dev Biol 47: 45–58PubMedCrossRefGoogle Scholar
  62. Ducibella T, Albertini DF, Anderson E, Biggers JD (1975) The preimplantation mammalian embryo: characterization of intercellular junctions and their appearance during development. Dev Biol 45: 231–250PubMedCrossRefGoogle Scholar
  63. Dyce J, George M, Goddall H, Fleming T (1987) Do trophectoderm and inner cell mass cells in the mouse blastocyst maintain discrete lineages? Development 100: 685–698PubMedGoogle Scholar
  64. Dziadek M, Adamson ED (1978) The localization and synthesis of alpha-fetoprotein in postimplantation mouse embryos. J Embryol Exp Morphol 43: 289–313PubMedGoogle Scholar
  65. Elbrecht A, DeMayo FJ, Tsai MJ, O’Malley BW (1987) Episomal maintenance of a bovine papilloma virus vector in transgenic mice. Mol Cell Bio’. 7: 1276–1279Google Scholar
  66. Enders AC, Given RL, Schlaffke S (1978) Differentiation and migration of endoderm in the rat and mouse at implantation. Anat Rec 190: 65–78PubMedCrossRefGoogle Scholar
  67. Eppig JJ (1985) Oocyte-somatic cell interactions during oocyte growth and maturation in the mammal. In: Browder LW (ed) Developmental biology, vol 1. Oogenesis, Plenum Press, New York, pp 313–347Google Scholar
  68. Epstein, CJ (1986) Generation and properties of mouse aneuploids. In: Epstein CJ (ed) The consequences of chromosome imbalance. Cambridge University Press, Cambridge, pp 207–232CrossRefGoogle Scholar
  69. Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292: 154–158PubMedCrossRefGoogle Scholar
  70. Fawcett DW (1975) The mammalian spermatozoon. Dev Biol 44: 394–436PubMedCrossRefGoogle Scholar
  71. Finn CA (1971) The biology of decidual cells. Adv Reprod Physiol 5: 1–26PubMedGoogle Scholar
  72. Fleming TP (1987) A quantitative analysis of cell allocation to trophectoderm and inner cell mass in the mouse blastocyst. Dev Biol 119: 520–531PubMedCrossRefGoogle Scholar
  73. Fleming TP, Pickering SJ (1985) Maturation and polarization of the endocytotic system in outside blastomeres during mouse preimplantation development. J Embryol Exp Morphol 89: 175–208PubMedGoogle Scholar
  74. Frischauf, AM (1985) The T/t complex of the mouse. TIG 1: 100–103CrossRefGoogle Scholar
  75. Gardner RL (1972) An investigation of inner cell mass and trophoblast tissue following their isolation from the mouse blastocyst. J Embryol Exp Morphol 28: 279–312PubMedGoogle Scholar
  76. Gardner RL (1975) Analysis of determination and differentiation in the early mammalian embryo using intra-and inter-specific chimaeras. In: Markert CL (ed) The developmental biology of reproduction. 33rd Symp of the Society for Developmental Biology. Academic Press, New York, pp 207–238Google Scholar
  77. Gardner RL, Johnson MH (1973) Investigation of early mammalian development using interspecific chimaeras between rat and mouse. Nature (New Biol) Lond 246: 86–89CrossRefGoogle Scholar
  78. Gardner RL, Rossant J (1979) Investigation of the fate of 4.5 day post coitum mouse inner cell mass cells by blastocyst injection. J Embryo! Exp Morphol 52: 141–152Google Scholar
  79. Gardner RL, Papaiaonoou VE, Barton SC (1973) Origin of the ectoplacental cone and secondary giant cells in mouse blastocysts reconstituted from isolated trophoblast and inner cell mass. J Embryol Exp Morphol 30: 561–572PubMedGoogle Scholar
  80. Gehring, WJ, Hiromi Y (1986) Homeotic genes and the homeobox. Annu Rev Genet 20: 147–173PubMedCrossRefGoogle Scholar
  81. Giebelhaus DH, Weitlauf HM, Schultz GA (1985) Actin mRNA content in normal and delayed implanting mouse embryos. Dev Biol 107: 407–413PubMedCrossRefGoogle Scholar
  82. Ginsburg M, Snow MHL, McLaren A (1990) Primordial germ cells in the mouse embryo during gastrulation. Development 110: 521–528PubMedGoogle Scholar
  83. Godin I, Wylie C, Heasman J (1990) Genital ridges exert long range effects on mouse primordinal germ cell numbers and direction of migration in culture. Development 108: 357–363PubMedGoogle Scholar
  84. Gordon JW (1983) Transgenic mice: a new and powerful experimental tool in mammlian developmental genetics. Dev Genet 4: 1–20CrossRefGoogle Scholar
  85. Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle FH (1980) Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77: 7380–7384PubMedCrossRefGoogle Scholar
  86. Gossler A, Doetschman T, Korn R, Serfling E, Kemler R (1986) Transgenesis by means of blastocyst derived embryonic stem cell lines. Proc Natl Acad Sci USA 83: 9065–9069PubMedCrossRefGoogle Scholar
  87. Gossler A, Joyner AL, Rossant J, Skarnes WC (1989) Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244: 463–465PubMedCrossRefGoogle Scholar
  88. Graham A, Papalopoulu N, Krumlauf R (1989) The murine and Drosophila homoebox gene complexes have common features of organization and expression. Cell 57: 367–378PubMedCrossRefGoogle Scholar
  89. Graves RA, Marzluff DH, Giebelhaus DH, Schultz GA (1985) Quantitative and qualitative changes in histone gene expression during early mous development. Proc Natl Acad Sci USA 82: 5685–5689PubMedCrossRefGoogle Scholar
  90. Greve JM, Wassarman PM (1985) Mouse egg extracellular coat is a matrix of interconnected filaments possessing a structural repeat. J Mol Biol 181: 253–264PubMedCrossRefGoogle Scholar
  91. Gridley T, Soriano P, Jaenisch R (1987) Insertional mutagenesis in transgenic mice. TIG 3: 162–166CrossRefGoogle Scholar
  92. Gropp A, Winking H (1981) Robertsonian translocations: cytology, meiosis, segregation patterns and biological consequences of heterozygosity. In: Berry RJ (ed) Biology of the house mouse. Academic Press, London, pp 141–181Google Scholar
  93. Gropp A, Winking H, Zech U, Müller H (1972) Robertsonian chromosomal variation and identification of metacentric chromosomes in feral mice. Chromosoma 39: 265–288PubMedCrossRefGoogle Scholar
  94. Grüneberg H (1954) Genetical studies on the development of the mouse. XII. The development of undulated. J Genet 52: 441–455CrossRefGoogle Scholar
  95. Guénet J-L, Simon-Chazottes D, Avner PR (1988) The use of interspecific mouse crosses for gene localization: present status aand future perspectives. In: Mock B, Potter M (eds) Current topics of microbiology and immunology 137. Springer, Berlin Heidelberg New York, pp 13–17Google Scholar
  96. Haldane JBS, Sprunt AD, Haldane NM (1915) Reduplication in mice. J Genet 5: 133–135CrossRefGoogle Scholar
  97. Hastie ND (1989) Highly repeated DNA families in the genome of Mus musculus. In: Lyon M F, Searle AG (eds) Genetic variants and strains of the laboratory mouse. Oxford University Press, Oxford, pp 559–573Google Scholar
  98. Heller DT, Cahill DM, Schultz RM (1981) Biochemical studies of mammalian oogenesis: metabolic cooperativity between granulosa cells and growing mouse oocytes. Dev Biol 84: 455–464PubMedCrossRefGoogle Scholar
  99. Herrmann BG, Labeit S, Poustka A, King TR, Lehrach H (1990) Cloning of the T gene required in mesoderm formation in the mouse. Nature 343: 617–622PubMedCrossRefGoogle Scholar
  100. Hillmann N, Sherman MI, Graham C (1972) The effect of spatial arrangement on cell determination during mouse development. J Embryol Exp Morphol 28: 263–278Google Scholar
  101. Hitotsumachi S, Carpenter DA, Russell WL (1985) Dose repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc Natl Acad Sci USA 82: 6619–6621PubMedCrossRefGoogle Scholar
  102. Hogan BLM, Newman R (1984) A scanning electron microscope study of the extraembryonic endoderm of the 8th-day mouse embryo. Differentiation 26: 138–143PubMedCrossRefGoogle Scholar
  103. Hogan BLM, Tilly R (1981) Cell interactions and endoderm differentiation in culture mouse embryos. J Embryol Exp Morphol 62: 379–394PubMedGoogle Scholar
  104. Hogan BLM, Cooper AR, Kurkinen M (1980) Incorporation into Reichert’s membrane of laminin-like extracellular proteins synthesized by parietal endoderm cells of the mouse embryo. Dev Biol 80: 289–300PubMedCrossRefGoogle Scholar
  105. Hogan BLM, Taylor A, Cooper AR (1982) Murine parietal endoderm cells synthesize heparan sulphate and 170 k and 145 k sulphated glycoproteins as components of Reichert’s membrane. Dev Biol 90: 210–214PubMedCrossRefGoogle Scholar
  106. Hogan BLM, Holland P, Schofield P (1985) How is the mouse segmented? TIG 1: 67–74CrossRefGoogle Scholar
  107. Hogan B, Constantini F, Lacy E (1986) Manipulating the mouse embryo. A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New YorkGoogle Scholar
  108. Hollander WF, Strong LC (1950) Intrauterine mortality and placental fusions in the mouse. J Exp Zool 115: 131–150CrossRefGoogle Scholar
  109. Hsu YC (1982) Development of mouse embryos in vitro: preimplantation to limb bud stage. Science 218: 66–68PubMedCrossRefGoogle Scholar
  110. Huszar D, Balling R, Kothary R, Magli MC, Hozumi N, Rossant J, Bernstein A (1985) Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector. Proc Natl Acad Sci USA 82: 8587–8591PubMedCrossRefGoogle Scholar
  111. Hyafil F, Morello D, Babinet C, Jacob F (1980) A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos. Cell 21: 927–934PubMedCrossRefGoogle Scholar
  112. Jaenisch R (1976) Germline integration and mendalian transmission of the exogenous Moloney leukemia virus. Proc Natl Acad Sci USA 73: 1260–1264PubMedCrossRefGoogle Scholar
  113. Jaenisch R (1980) Retroviruses and embryogenesis: microinjection of Moloney leukemia virus into midgestation mouse embryos. Cell 19: 181–188PubMedCrossRefGoogle Scholar
  114. Jaenisch R, Harbers K, Schnieke A, Lohler J, Chumakov I, Jähner D, Grotkopp D, Hoffmann E (1983) Germ line integration of Moloney murine leukemia virus at the Mov 13 locus leads to recessive lethal mutation and early embryonic death. Cell 32: 209–216PubMedCrossRefGoogle Scholar
  115. Jähner D, Haase K, Mulligan R, Jaenisch R (1985) Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection. Proc Natl Acad Sci USA 82: 6927–6931PubMedCrossRefGoogle Scholar
  116. Johnson MH (1986) Manipulation of early mammalian development: what does it tell us about cell lineages? In: Gwatkin RBL (ed) Developmental biology: a comprehensive synthesis. Plenum Press, New York, pp 279–296Google Scholar
  117. Johnson MH, Maro B (1984) The distribution of cytoplasmic actin in mouse eight cell blastomeres. J Embryol Exp Morphol 82: 97–117PubMedGoogle Scholar
  118. Johnson MH, Ziomek CA (1981) The foundation of two distinct cell lineages within the mouse morula. Cell 24: 71–80PubMedCrossRefGoogle Scholar
  119. Joyner AL, Herrup K, Auerbach A, Davis CA, Rossant R (1991) Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 251: 1239–1243PubMedCrossRefGoogle Scholar
  120. Joyner AL, Skarnes WC, Rossant R (1989) Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells. Nature 338: 153–156PubMedCrossRefGoogle Scholar
  121. Jurand A (1974) Some aspects of the development of the notochord in mouse embryos. J Embryol Exp Morphol 32: 1–33PubMedGoogle Scholar
  122. Kaufman MH (1990) Morphological stages of postimplantation development. In: Copp AJ, Cockroft DL (eds) Postimplantation mammalian embryos: a practical approach. IRL Press, Oxford, pp 81–91Google Scholar
  123. Kelly SJ (1977) Studies on the developmental potential of 4- and 8-cell stage mouse blastomeres. J Exp Zool 200: 365–376PubMedCrossRefGoogle Scholar
  124. Kemler R, Babinet C, Eisen H, Jacob F (1977) Surface antigen in early differentiation. Proc Natl Acad Sci USA 74: 4449–4452PubMedCrossRefGoogle Scholar
  125. King TR, Dove WF, Herrmann B, Moser AR, Shedlovsky A (1989) Mapping to molecular resolution in the T to H-2 region of the mouse genome with a nested set of meiotic recombinants. Proc Natl Acad Sci USA 86: 222–226PubMedCrossRefGoogle Scholar
  126. Koller BH, Hagemann LJ, Doetschman T, Hagaman JR, Huang S, Williams PJ, First NL, Maeda N, Smithies 0 (1989) Germ line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci USA 86: 8927–8931Google Scholar
  127. Kothary R, Clapoff S, Brown A, Campbell R, Peterson A, Rossant J (1989) A transgene containing a lacZ inserted into the dystonia locus is expressed in the neural tube. Nature 335: 435–437CrossRefGoogle Scholar
  128. Kuehn MR, Bradley A, Robertson EJ, Evans MJ (1987) A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326: 295–298PubMedCrossRefGoogle Scholar
  129. Lallemand Y, Brulet P (1990) An in situ assessment of the routes and extents of colonization of the mouse embryo by embryonic stem cells and their descendants. Development 110: 1241–1248PubMedGoogle Scholar
  130. Lawson KA, Pedersen RA (1987) Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse. Development 101: 627–652PubMedGoogle Scholar
  131. Lawson KA, Meneses JJ, Pedersen RA (1986) Cell fate and cell lineage in the endoderm of the presomite mouse embryo studies with an intracellular tracer. Dev Biol 115: 325–339PubMedCrossRefGoogle Scholar
  132. Le Douarin N (1982) The neural crest. Cambridge University Press, CambridgeGoogle Scholar
  133. Le Mouellic H, Lallemand Y, B1-filet P (1990) Targeted replacement of the homeobox gene Hox 3.1 by the Escherichia coli lacZ in mouse chimeric embryos. Proc Natl Acad Sci USA 87: 4712–4716Google Scholar
  134. Levey IL, Stull GB, Brinster RL (1978) Poly(A) and synthesis of polyadenylated RNA in the preimplantation mouse embryo. Dev Biol 64: 140–148PubMedCrossRefGoogle Scholar
  135. Lufkin T, Dierich A, LeMeur M, Mark M, Chambon P (1991) Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell 66: 1105–1119PubMedCrossRefGoogle Scholar
  136. Lyon MF, Searle AG eds (1989) Genetic variants and strains of the laboratory mouse. Oxford University Press, OxfordGoogle Scholar
  137. Lyon MF, Phillips RJS, Fisher G (1982) Use of an inversion to test for induced X-linked lethals in mice. Mutat Res 92: 217–228PubMedCrossRefGoogle Scholar
  138. Mansour SL, Thomas KR, Capecchi MR (1988) Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336: 348–352PubMedCrossRefGoogle Scholar
  139. Mansour SL, Thomas KR, Deng C, Capecchi MR (1990) Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc Natl Acad Sci USA 87: 7688–7692PubMedCrossRefGoogle Scholar
  140. Maro B, Johnson MH, Pickering SJ, Louvard D (1985) Changes in the distribution of membranous organelles during mouse early development. J Embryol Exp Morphol 90: 287–309PubMedGoogle Scholar
  141. Martin GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Nat Acad Sci USA: 78: 7634–7638PubMedCrossRefGoogle Scholar
  142. McGrath J, Solter D (1983) Nuclear transplantation in the mouse embryo by microsurgery and cell fusion. Science 220: 1300–1302PubMedCrossRefGoogle Scholar
  143. McGrath J, Solter D (1984) Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro. Science 226: 1317–1319PubMedCrossRefGoogle Scholar
  144. McGrath J, Solter D (1986) Nucleocytoplasmic interactions in the mouse embryo. J Embryol Exp Morphol 97 (Suppl): 277–289PubMedGoogle Scholar
  145. McMahon AP, Bradley A (1990) The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62: 1073–1085PubMedCrossRefGoogle Scholar
  146. Meehan RR, Barlow DP, Hill RE, Hogan BLM, Hastie ND (1984) Pattern of serum protein gene expression in mouse visceral yolk sac and fetal liver. EMBO J 3: 1881–1885PubMedGoogle Scholar
  147. Meier S, Tam PPL (1982) Metameric pattern development in the embryonic axis of the mouse. I. Differentiation of the cranial segments. Differentiation 21: 95–108Google Scholar
  148. Miller DA, Miller OJ (1972) Chromosome mapping in the mouse. Science 178: 949–955PubMedCrossRefGoogle Scholar
  149. Miller OJ, Miller DA (1975) Cytogenetics of the mouse. Annu Rev Genet 9: 285–303PubMedCrossRefGoogle Scholar
  150. Monk M (ed) (1987) Mammalian development: a practical approach. IRL Press, OxfordGoogle Scholar
  151. Nadeau JH, Reiner AH (1989) Linkage and synteny relationships in mouse and man. In: Lyon MF, Searle AG (eds) Genetic variants and strains of the laboratory mouse. Oxford University Press, Oxford, pp 506–536Google Scholar
  152. Nadijcka M, Hillman N (1974) Ultrastructural studies of the mouse blastocyst substages. J Embryol Exp Morphol 32: 675–695PubMedGoogle Scholar
  153. Nagy A, Gócza E, Merentes Diaz E, Prideaux VR, Ivânyi E, Markkula M, Rossant R (1990) Embryonic stem cells alone are able to support embryonic development in the mouse. Development 110: 815–821PubMedGoogle Scholar
  154. Nocka K, Majumder S, Chabot B, Ray P, Cervone M, Bernstein A, Besmer P (1989) Expression of the c-kit gene products in known cellular targets of W mutations in normal and W mutant mice — evidence for an impaired c-kit kinase in mutant mice. Genes Dev 3: 816–826PubMedCrossRefGoogle Scholar
  155. O’Kane C, Gehring W (1987) Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci USA 84: 9123–9127PubMedCrossRefGoogle Scholar
  156. Painter TS (1927) The chromosome constitution of Gates’ “non disjunction” (v-o) mice. Genetics 12: 379–392PubMedGoogle Scholar
  157. Palmiter RD, Brinster RL (1986) Germ line transformation of mice. Annu Rev Genet 20: 465–499PubMedCrossRefGoogle Scholar
  158. Palmiter RD, Behringer RR, Quaife CJ, Maxwell IH, Brinster RL (1987) Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell 50: 435–443PubMedCrossRefGoogle Scholar
  159. Panthier J-J, Condamine H, Jacob F (1988) Inoculation of newborn SWR/J females with an ecotropic murine leukemia virus can produce transgenic mice. Proc Natl Acad Sci USA 85: 1156–1160PubMedCrossRefGoogle Scholar
  160. Papaioannou VE (1982) Lineage analysis of inner cell mass and trophectoderm using microsurgically reconstituted mouse blastocysts. J Embryol Exp Morphol 68: 199–209PubMedGoogle Scholar
  161. Pedersen RA, Wu K, Balakier H (1986) Origin of the inner cell mass in mouse embryos: cell lineage analysis by microinjection. Dev Biol 117: 581–595PubMedCrossRefGoogle Scholar
  162. Perona RM, Wassarman PM (1986) Mouse blastocysts hatch in vitro by using a trypsin-like proteinase associated with cells of mural trophectoderm. Dev Biol 114: 42–52PubMedCrossRefGoogle Scholar
  163. Petzhold U, Hoppe PC, Illmensee K (1980) Protein synthesis in enucleated fertilized and unfertilized mouse eggs. Wilhelm Roux’s Arch Dev Biol 189: 215–219CrossRefGoogle Scholar
  164. Piko L, Clegg KB (1982) Quantitative changes in total RNA, total poly(A) and ribosomes in early mouse embryos. Dev Biol 89: 362–378PubMedCrossRefGoogle Scholar
  165. Poelman RE (1981a) The formation of embryonic mesoderm in the early post-implantation mouse embryo. Anat Embryol 162: 29–40CrossRefGoogle Scholar
  166. Poelman RE (1981b) The head process and the formation of the diefinitive endoderm in the mouse. Anat Embryol 162: 41–49CrossRefGoogle Scholar
  167. Pohl TM, Mattei MG, Rüther U (1990) Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt). Development 110: 1153–1157PubMedGoogle Scholar
  168. Pratt HPM (1985) Membrane organization in the preimplantation mouse embryo. J Embryol Exp Morphol 90: 101–121PubMedGoogle Scholar
  169. Price J (1987) Retroviruses and the study of cell lineages. Development 101: 409–419PubMedGoogle Scholar
  170. Price J, Turner DL, Cepko CL (1987) Lineage analysis in the vertebrate nervous system by retrovirus mediated gene transfer. Proc Natl Acad Sci USA 84: 156–160PubMedCrossRefGoogle Scholar
  171. Rassoulzadegan M, Leopold P, Vailly J, Cuzin F (1986) Germ line transmission of autonomous genetic elements in transgenic mouse strains. Cell 46: 513–519PubMedCrossRefGoogle Scholar
  172. Rastan S (1983) Non-random X inactivation in mouse X-autosome translocation embryos — location of the inactivation centre. J Embryol Exp Morphol 78: 1–2PubMedGoogle Scholar
  173. Reeve WJD, Ziomek CA (1981) Distribution of microvilli on dissociated blastomeres from mouse embryos: evidence for surface polarization at compaction. J Embryol Exp Morphol 62: 339–350PubMedGoogle Scholar
  174. Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A (1990) W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev 4: 390–400PubMedCrossRefGoogle Scholar
  175. Rinchik EM (1991) Cemical mutagenesis and fine-structure functional analysis of the mouse genome. TIG 7: 15–21PubMedCrossRefGoogle Scholar
  176. Rinchik EM, Bangham JW, Hundsicker PR, Cacheiro NLA, Kwon BS, Jackson IJ, Russell LB (1990a) Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse. Proc Natl Acad Sci USA 87: 1416–1420PubMedCrossRefGoogle Scholar
  177. Rinchik EM, Carpenter DA, Selby PB (1990b) A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci USA 87: 896–900PubMedCrossRefGoogle Scholar
  178. Robert B, Barton P, Minty A, Daubas P, Weydert A, Bonhomme F, Catalan J, Chazottes D, Guénet J-L, Buckingham M (1985) Investigation of genetic linkage between myosin and actin genes using an interspecific mouse backcross. Nature 314: 181–183PubMedCrossRefGoogle Scholar
  179. Robertson E, Bradley A, Kuehn M, Evans M (1986) Germ line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 323: 445–448PubMedCrossRefGoogle Scholar
  180. Robertson EJ (ed) (1987) Teratocarcinomas and embryonic stem cells: a practical approach. IRL Press, OxfordGoogle Scholar
  181. Roderick TH, Hawes NL (1970), Two radiation induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci USA 67: 961–967PubMedCrossRefGoogle Scholar
  182. Roderick TH, Hawes NL (1974) Nineteen paracentric chromosomal inversion in mice. Genetics 76: 109–117PubMedGoogle Scholar
  183. Rosenberg UB, Schröder C, Preiss A, Kienlin A, Cote S, Riede I, Jäckle H (1986) Structural homology of the Drosophila Krüppel gene with Xenopus transcription factor ILIA. Nature 319: 336–339CrossRefGoogle Scholar
  184. Rossant J (1976a) Postimplantation development of blastomeres isolated from 4- and 8-cell mouse eggs. J Embryol Exp Morphol 36: 283–290PubMedGoogle Scholar
  185. Rossant J (1976b) Investigation of inner cell mass determination by aggregation of isolated rat inner cell masses with mouse morulae. J Embryol Exp Morphol 36: 163–174PubMedGoogle Scholar
  186. Rossant J (1977) Cell commitment in early rodent development. In: Johnson MH (ed) Development in mammals, vol 2. North Holland, Amsterdam, pp 119–150Google Scholar
  187. Rossant J, Joyner AL (1989) Towards a molecular genetic analysis of mammalian development. TIG 5: 277–283PubMedCrossRefGoogle Scholar
  188. Rossant J, Lis WT (1979) The possible dual origin of the ectoderm of the chorion in the mouse embryo. Dev Biol 70: 249–254PubMedCrossRefGoogle Scholar
  189. Rossant J, Ofer L (1977) Properties of extraembryonic ectoderm isolated from postimplantation mouse embryos. J Embryol Exp Morphol 39: 183–194PubMedGoogle Scholar
  190. Rossant J, Vijh KM (1980) Ability of outside cells from preimplantation mouse embryos to form inner cell mass derivatives. Dev Biol 76: 475–482PubMedCrossRefGoogle Scholar
  191. Rossant J, Gardner RL, Alexandre HL (1978) Investigation of the potency of cells from the mouse postimplantation embryo by blastocystinjection: a preliminary report. J Embryol Exp Morphol 48: 239–247PubMedGoogle Scholar
  192. Rugh R (1990) The mouse. Its reproduction and development. Oxford University Press, LondonGoogle Scholar
  193. Russell ES (1979) Hereditary anemias of the mouse: a review for geneticists. Adv Genet 20: 357–459PubMedCrossRefGoogle Scholar
  194. Russell ES (1985) A history of mouse genetics. Annu Rev Genet 19: 1–28PubMedCrossRefGoogle Scholar
  195. Russel LB (1983) X-autosome translocations in the mouse: their characterization and use as tools to investigate gene inactivation and gene action. In: Sandberg AA (ed) Cytogenetics of the mammalian X chromosome, Part A. Alan Liss, New York, pp 205–250Google Scholar
  196. Russell WL (1962) An augmenting effect of dose fractionation on radiation induced mutation rate in mice. Proc Natl Acad Sci USA 48: 1724–1727PubMedCrossRefGoogle Scholar
  197. Sanes JR, Rubenstein JLR, Nicolas JF (1986) Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J 5: 3133–3142PubMedGoogle Scholar
  198. Sawicki JA, Magnuson T, Epstein CJ (1981) Evidence for expression of the paternal genome in the two-cell mouse embryo. Nature 295: 450–451CrossRefGoogle Scholar
  199. Schnedl W (1971) The karyotype of the mouse. Chromosoma 35: 111–116PubMedCrossRefGoogle Scholar
  200. Schultz GA (1986) Molecular biology of the early mouse embryo. Biol Bull 171: 291–309CrossRefGoogle Scholar
  201. Sawicki JA, Magnuson T, Epstein CJ (1982) Evidence for expression of the paternal genome in the two-cell mouse embryo. Nature 294: 450–451CrossRefGoogle Scholar
  202. Schultz RM, Letourmeau GE, Wassarman PM (1979) Program of early development in the mammal: changes in patterns and absolute rates of synthesis of tubulin and total protein synthesis during oogenesis and early embryogenesis in the mouse. Dev Biol 68: 341–359PubMedCrossRefGoogle Scholar
  203. Searle AG (1989) Chromosomal variants. In: Lyon MF, Searle AG (eds) Genetic variants and strains of the laboratory mouse. Oxford University Press, Oxford, pp 582–616Google Scholar
  204. Shashikant CS, Utset MF, Violette SM, Wise TL, Einat M, Einat J, Pendleton JW, Schughart K, Ruddle FH (1991) Homeobox genes in mouse development. Crit Rev Eucaryotic Gene Expression 1 (3): 207–245Google Scholar
  205. Shedlovsky A, Guénet J-L, Johnson LL, Dove WF (1986) Introduction of induced recessive lethal mutations in the T/t-H2 region of the mouse genome via a point mutagen. Genet Res 47: 135–142PubMedCrossRefGoogle Scholar
  206. Shedlovsky A, King TR, Dove WF (1988) Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus. Proc Natl Acad Sci USA 85: 180–184PubMedCrossRefGoogle Scholar
  207. Shur BD, Hall NG (1982a) Sperm surface galactosyltransferase activities during in vitro capacitation. J Cell Biol 95: 567–573PubMedCrossRefGoogle Scholar
  208. Shur BD, Hall NG (1982b) A role for mouse sperm surface galactosyltransferase in sperm binding to the egg zona pellucida. J Cell Biol 95: 574–579PubMedCrossRefGoogle Scholar
  209. Silver, L (1985) Mouse t-haplotypes. Annu Rev Genet 19: 179–208PubMedCrossRefGoogle Scholar
  210. Smith KK, Strickland S (1981) Structural components and characteristics of Reichert’s membrane, an extra-embryonic basement membrane. J Biol Chem 256: 4654–4661PubMedGoogle Scholar
  211. Smith LJ (1980) Embryonic axis orientation in the mouse and its correlation with blastocyst relationships to the uterus, Part I. Relationships between 82 hours and 41/4 days. J Embryol Exp Morphol 55: 257–272PubMedGoogle Scholar
  212. Smith LJ (1985) Embryonic axis orientation in the mouse and its correlation with blastocyst relationships to the uterus, Part II. Relationships from 4 1/4 to 91 days. J Embryol Exp Morphol 89: 15–35PubMedGoogle Scholar
  213. Smith R, McLaren A (1977) Factors affecting the time of formation of the blastocoele. J Embryol Exp Morphol 41: 79–92PubMedGoogle Scholar
  214. Snell GD (1946) An analysis of translocations in the mouse. Genetics 31: 157–180Google Scholar
  215. Snell GD, Stevens LC (1966) Early embryology. In: Green EL (ed) Biology of the laboratory mouse, 2nd edn. McGraw-Hill, New York, pp 205–245Google Scholar
  216. Snow MHL (1977) Gastrulation in the mouse: growth and regionalization of the epiblast. J Embryol Exp Morphol 42: 293–303Google Scholar
  217. Soriano P, Jaenisch R (1986) Retroviruses as probes for mammalian development: Allocation of cells to the somatic and germ cell lineage. Cell 46: 19–29Google Scholar
  218. Soriano P, Cone RD, Mulligan RC, Jaenisch R (1986) Tissue specific and ectopic expression of genes introduced into transgenic mice by retroviruses. Science 234: 1409–1413PubMedCrossRefGoogle Scholar
  219. Soriano P, Gridley T, Jaenisch R (1987) Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death. Genes Dev 1: 366–375PubMedCrossRefGoogle Scholar
  220. Stambaugh R, Buckley U (1960) Identification and subcellular localization of the enzymes affecting the penetration of the zona pellucida by rabbit spermatozoa. J Reprod Fertil 19: 423–432Google Scholar
  221. Stambaugh R, Mastroianni L (1980) Stimulation of rhesus monkey (Macaca mulatta) proacrosin activation by oviduct fluid. J Reprod Fertil 59: 479–484PubMedCrossRefGoogle Scholar
  222. Stewart CL, Schuetze S, Vanek M, Wagner EF (1987) Expression of retroviral vectors in transgenic mice obtained by embryo infection. EMBO J 6: 383–388PubMedGoogle Scholar
  223. Stewart CL, Vanek M, Wagner EF (1985) Expression of foreign genes from retroviral vectors in mouse teratocarcinoma chimaeras. EMBO J 4: 3701–3709PubMedGoogle Scholar
  224. Tam PPL (1986) A study on the pattern of prospective somites in the presomitic mesoderm of mouse embryos. J Embryol Exp Morphol 92: 269–285PubMedGoogle Scholar
  225. Tam PPL (1989) Regionalisation of the mouse embryonic ectoderm: allocation of prospective ectodermal tissues during gastrulation. Development 107: 55–67PubMedGoogle Scholar
  226. Tam PPL, Beddington RSP (1987) The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis. Development 99: 109–126PubMedGoogle Scholar
  227. Tam PPL, Snow MHL (1981) Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos. J Embryol Exp Morphol 64: 133–147PubMedGoogle Scholar
  228. Tam PPL, Meier S, Jacobson AG (1982) Differentiation of the metameric pattern in the embryonic axis of the mouse. II. Somitomeric organization in the presomitic mesoderm. Differentiation 21: 109–122Google Scholar
  229. Tarkowski AK (1959) Experiments on the development of isolated blastomeres of mouse eggs. Nature 184: 1286–1287PubMedCrossRefGoogle Scholar
  230. Tarkowski AK, Wróblewska J (1967) Development of blastomeres of mouse eggs isolated at the 4- and 8- cell stage. J Embryol Exp Morphol 18: 155–180PubMedGoogle Scholar
  231. te Riele H, Maandag ER, Clarke A, Hooper M, Berns A (1990) Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells. Nature 348: 649–651CrossRefGoogle Scholar
  232. Theiler K (1989) The house mouse. Atlas of embryonic development. Springer, Berlin Heidelberg New YorkGoogle Scholar
  233. Thomas KR, Capecchi M (1987) Site-directed mutagenesi by gene targeting in mouse embryo-derived stem cells. Cell 51: 503–512PubMedCrossRefGoogle Scholar
  234. Turner DL, Cepko CL (1987) A common progenitor for neurons and glia persists in rat retina late development. Nature 328: 131–136PubMedCrossRefGoogle Scholar
  235. Van der Putten H, Botteri FM, Miller AD, Rosenfeld MG, Fan H, Evans RM, Verma IM (1985) Efficient insertion of genes into the mouse germ line via retroviral vectors. Proc Natl Acad Sci USA 82: 6148–6152PubMedCrossRefGoogle Scholar
  236. Vestweber D, Kemler R (1984) Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with adult tissues. Exp Cell Res 152: 169–178PubMedCrossRefGoogle Scholar
  237. Vestweber D, Gossler A, Boller K, Kemler R (1987) Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos. Dev Biol 124: 451–456PubMedCrossRefGoogle Scholar
  238. Wagner EF, Stewart TA, Mintz B (1981) The human β-globin gene and a functional thymidine kinase gene in developing mice. Proc Natl Acad Sci USA 78: 5016–5020PubMedCrossRefGoogle Scholar
  239. Wagner TE, Hoppe PC, Jollik JD, Scholl DR, Hodinka RL, Gault JB (1981) Microinjection of a rabbit (3-globin gene into zygotes and its subsequent expression in adult mice and their offspring. Proc Natl Acad Sci USA 78: 6376–6380PubMedCrossRefGoogle Scholar
  240. Walther C, Guenét JL, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R, Gruss P (1991) Pax: a murine multigene family of paired box containing genes. Genomics 11: 424–434Google Scholar
  241. Warner CM, Versteegh LR (1974) In vivo and in vitro effect of u-amanitin on preimplantation mouse embryo RNA polymerase. Nature 248: 678–680PubMedCrossRefGoogle Scholar
  242. Wassarman PM (1987) The biology and chemistry of fertilization. Science 235: 553–560PubMedCrossRefGoogle Scholar
  243. Whitten W (1971) Nutrient requirements for the culture of preimplantation embryos in vitro. Adv Biosci 6: 129–140Google Scholar
  244. Wilson C, Pearson RK, Bellen HJ, O’Kane CJ, Grossniklaus U, Gehring WJ (1989) P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev 3: 1301–1313PubMedCrossRefGoogle Scholar
  245. Willison K (1990) The mouse brachyury gene and mesoderm formation. TIG 6: 104–105PubMedCrossRefGoogle Scholar
  246. Wincek TJ, Parrish RF, Polakoski KL (1979) Fertilization: a uterine glycosaminoglycan stimulates the conversion of sperm proacrosin to acrosin. Science 203: 553–554PubMedCrossRefGoogle Scholar
  247. Woychik RW, Stewart TA, Davis LG, D’Eustachio P, Leder P (1985) An inherited limb deformity created by insertional mutagenesis in a transgenic mouse. Nature 318: 36–40PubMedCrossRefGoogle Scholar
  248. Wudl L, Chapman V (1976) The expression of 3-glucuronidase during preimplantation development of mouse embryos. Dev Biol 48: 104–109PubMedCrossRefGoogle Scholar
  249. Wylie CC, Stott D, Donovan PJ (1985) Primordial germ cells migration. In: Browder LW (ed) Developmental biology, vol 2. Plenum Press, New York, pp 433–448Google Scholar
  250. Xin Xiang, KF Benson, Chada K (1990) Mini mouse: disruption of the Pygmy locus in a transgenic insertional mutant. Science 247: 967–969PubMedCrossRefGoogle Scholar
  251. Yagi T, Ikawa Y, Yoshida K, Shigetani Y, Takeda N, Mabuchi I, Yamamoto T, Aizawa S (1990) Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphteria toxin A fragment gene in negative selection. Proc Natl Acad Sci USA 87: 9918–9922PubMedCrossRefGoogle Scholar
  252. Yoshida-Noro C, Suzuki N, Takeichi M (1984) Molecular nature of calcium-dependent cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody. Dev Biol 101: 19–27PubMedCrossRefGoogle Scholar
  253. Zijlstra M, Li E, Sajjadi F, Subramani S, Jaenisch R (1989) Germ line transmission of a disrupted 132-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342: 435–428PubMedCrossRefGoogle Scholar
  254. Zimmer A, Gruss P (1989) Production of chimaeric mice containing ES cells carrying a homeobox Hox 1.1 allele mutated by homologous recombination. Nature 338: 150–153PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  1. 1.Max-Delbrück-Laboratorium in der MPGKöln 30Germany

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