Abstract
-
Clinical presentations
-
Assessment of risk for recurrence
-
Options for treatment
-
Management of the facial nerve
-
Results of treatment of the parotid gland
-
Risks of Malignant Transformation
-
Role of radiation therapy
-
Recurrent submandibular gland pleomorphic adenoma
-
Recurrent minor salivary gland pleomorphic adenoma
-
Conclusion
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alves FA, Perez DEC, Almeida OP, et al. (2002) Pleomorphic adenoma of the submandibular gland. Arch Otolarngol Head Neck Surg 128:1400–1403
Armitstead PR, Smiddy FG, Frank HG (1979) Simple enucleation and radiotherapy in the treatment of pleomorphic adenoma of the parotid gland. Br J Surg 66:716–717
Barton J, Slevin NJ, Gleaves EN (1992) Radiotherapy for pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 22:925–928
Bradley PJ (1999) Submandibular gland and minor salivary gland neoplasms. Curr Opin Otolaryngol Head Neck Surg 7:72–78
Bradley PJ (2001) Recurrent salivary gland pleomorphic adenoma: etiology, management, and results. Curr Opin Otolaryngol Head Neck Surg 9:100–109
Bradley PJ (2004) Editorial overview. Pleomorphic salivary adenoma of the parotid gland: which operation to perform? Curr Opin Otolaryngol Head Neck Surg 12:69–70
Bradley PJ (2005) Metastasizing pleomorphic salivary adenoma should now be considered a low-grade malignancy with a lethal potential. Curr Opin Otolaryngol Head Neck Surg 13:123–126
Bradley PJ, McClelland L, Metha D (2006) Paediatric salivary gland epithelial neoplasms. ORL J Otorhinolaryngol Relat Spec 69:137–145
Buchholz TA, Laramore GE, Griffin TW (1992) Fast neutron radiation for recurrent pleomorphic adenoma of the parotid gland. Am J Clin Oncol 15:441–115
Buchman G, Stringer SP, Mendenhall WM (1994) Pleomorphic adenoma: effect of tumor spill and inadequate resection on tumor recurrence. Laryngoscope 104:1231–1234
Carew JF, Spiro RH, Singh B, et al. (1999) Treatment of recurrent pleomorphic adenoma of the parotid gland. Otolaryngol Head Neck Surg 121:539–542
Chen RL, Wang CM, Wen YM (2004) Study of the relative factors of the biological behaviour of pleomorphic adenoma of parotid. Zhonghua Kou Qiang Yi Xue Za Zhi 39:277–279
Clairmont AA, Richardson GS, Hanna DC (1977) The pseudocapsule of pleomorphic adenoma (benign mixed tumors). Am J Surg 134:242–243
Commins DJ, Roberts D, Fisher C, et al. (1995) Seeding of a parotid pleomorphic adenoma. J Laryngol Otol 109:671–673
Curry JL, Petruzzelli GJ, McClatchey KD, et al. (2002) Synchronous benign and malignant salivary gland tumors in ipsilateral glands: a report of two cases and a review of literature. Head Neck 24:302–306
Dawson AK (1989) Radiation therapy in recurrent pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 16:819–821
Dawson AK, Orr LA (1985) Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 11:451–455
Douglas JG, Einck J, Austin-Seymour M, et al. (2001) Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands. Head Neck 23:1037–1042
Dulguerov P, Marchal F, Lehmann W (1999) Post parotidectomy facial nerve paralysis: possible aetiological factors and results with routine facial nerve monitoring. Laryngoscope 109:754–762
Erol B, Ozer N, Unlu G, et al. (1997) A massive pleomorphic adenoma of the submandibular salivary gland. J Oral Maxillofac Surg 55:1011–1014
Fee WE Jr, Goffinet DR, Calcaterra TC (1987) Recurrent mixed tumors of the parotid gland: results of surgical therapy. Laryngoscope 88:265–273
Fleming WB (1987) Recurrent pleomorphic adenoma of the parotid gland. Aust N Z J Surg 57:173–176
Glas AS, Vermey A, Hollema H, et al. (2001) Surgical treatment of recurrent pleomorphic adenoma of the parotid gland: a clinical analysis of 52 patients. Head Neck 23:311–316
Gnepp DR (1993) Malignant mixed tumors of the salivary glands: a review. Pathol Ann 28:279–328
Gnepp DR, Schroeder W, Heffner D (1989) Synchronous tumors arising in a single major salivary gland. Cancer 63:1219–1224
Graham SM, McCullach TM, Funk GF, et al. (1999) Recurrent benign parotid tumors: the lesson not learnt yet [comment]. Aust N Z Surg 69:531
Hancock BD (1999) Clinically benign parotid tumors: local dissection as an alternative to superficial parotidectomy in selected cases. Ann R Coll Surg Engl 81:299–301
Helmus C, Myssiorek D, Shemem LJ (1999) Clinical challenges in otolaryngology: conservation vs superficial parotidectomy for benign lesions of the parotid tail. Arch Otolaryngol Head Neck Surg 125:1164–1167
Hendrikisson HH, Westrin KM, Carlsoo B, et al. (1998) Recurrent primary pleomorphic adenomas of salivary origin. Cancer 82:617–620
Hodge CW, Morris CG, Werning JW, et al. (2005) Role of radiotherapy for pleomorphic adenoma. Am J Clin Oncol 28:148–151
Hoorweg JJ, Hilgers FJM, Keus RB, et al. (1998) Metastasising pleomorphic adenoma: a report of three cases. Eur J Surg Oncol 24:452–455
Jackson SR, Roland NJ, Clarke RW, et al. (1993) Recurrent pleomorphic adenoma. J Laryngol Otol 103:546–549
Junquera L, Alonso D, Sampedro A, et al. (1999) Pleomorphic adenoma of the salivary glands: prospective clinicopathologic and flow cytometric study. Head Neck 21:652–656
Karatzanis AD, Drivas EI, Giannikaki ES, et al. (2005) Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate. Auris Nasus Larynx 32:435–437
Laskawi R, Ellies M, Arglebe C, et al. (1995) Surgical management of benign tumors of the submandibular gland: a follow-up study. J Oral Maxillofac Surg 53:506–508
Laskawi R, Schott T, Schroder M (1998) Recurrent pleomorphic adenoma of the parotid gland: clinician evaluation and long-term follow up. Br J Oral Maxillofac Surg 36:48–51
Lawson HH (1989) Capsular penetration and perforation in pleomorphic adenoma of the parotid salivary gland. Br J Surg 76:594–596
Leonetti JP, Marzo SJ, Petruzzelli GJ, et al. (2005) Recurrent pleomorphic adenoma of the parotid gland. Otolaryngol Head Neck Surg 133:319–322
Leverstein H, Tiwari RM, Snow GB, et al. (1997) The surgical management of recurrent or residual pleomorphic adenoma of the parotid gland: analysis and results of 40 patients. Eur Arch Otorhinolaryngol 254:313–317
Liu F-F, Rotstein L, Davison AJ, et al. (1995) Benign parotid adenomas: a review of the Princess Margaret Hospital Experience. Head Neck 17:177–183
Mann W, Beck C, Karatay MC (1985) Recurrent benign tumors of the parotid gland and their tendency for becoming malignant. Laryngol Rhinol Otol (Stuttg) 64:133–135
Maran AGD, MacKenzie IJ, Stanley RE (1984) Recurrent pleomorphic adenoma of the parotid gland. Arch Otolaryngol 110:167–171
Makeieff M, Venail F, Cartier C, et al. (2005) Continuous facial nerve monitoring during pleomorphic adenoma recurrence surgery. Laryngoscope 115:1310–1314
Maxwell EL, Hall FT, Freeman JL (2004) Recurrent pleomorphic adenoma of the parotid gland. J Otolaryngol 33:181–184
McEvedy BV, Ross WM (1976) The treatment of mixed parotid tumors by enucleation and radiotherapy. Br J Surg 63:341–342
McGregor AD, Burgoyne M, Tan KC (1988) Recurrent pleomorphic adenoma salivary adenoma: the relevance of age at first presentation. Br J Plast Surg 41:177–181
McGurk M (2004) Benign parotid tumors. BMJ 329:1299–1300
McGurk M, Hussain K (1997) Role of fine needle aspiration cytology in the management of the discrete parotid lump. Ann R Coll Surg Engl 79:198–202
McGurk M, Thomas BL, Renehan AG (2003) Extracapsular dissection for clinically benign parotid lumps: reduced morbidity without oncological compromise. Br J Cancer 89:1610–1613
Munir N, Bradley PJ (2007) Pleomorphic adenoma of the submandibular gland: what form of surgical management should be undertaken? Eur Arch Otorhinolaryngol Head Neck Surg (in press)
Munir N, Bradley PJ (2007) Diagnosis and management of neoplastic lesions of the submandibular triangle. Oral Oncol (in press)
Myssiorek D, Ruah GB, Hybels RL (1990) Recurrent pleomorphic adenomas of the parotid gland. Head Neck 12:332–336
Natvig K, Soberg R (1994) Relationship of intraoperative rupture of pleomorphic adenoma to recurrence: an 11–25 year follow up study. Head Neck 16:213–217
Niparko JK, Beauchamp ML, Krause CJ, et al. (1986) Surgical treatment of recurrent pleomorphic adenoma of the parotid gland. Arch Otolaryngol Head Neck Surg 112:1180–1184
Nouraei SAR, Fergusin MS, Clarke PM, et al. (2006) Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg 132:788–793
Olsen KD, Daube JR (1994) Intra-operative monitoring of the facial nerve: an aid in the management of parotid gland pleomorphic adenomas. Laryngoscope 104:232–239
Olsen KD, Lewis JE (2001) Carcinoma ex-pleomorphic adenoma: a clinicopathologic review. Head Neck 23:705–712
Paris J, Facon F, Chrestian MA, et al. (2003) Recurrences of pleomorphic adenomas of the parotid: changing attitudes. Rev Laryngol Otol Rhinol (Bord) 124:229–234
Patel SG, See ACH, Williamson PA, et al. (1999) Radiation induced sarcoma of the head and neck. Head Neck 21:346–349
Phillips PP, Olsen KD (1995) Recurrent pleomorphic adenoma of the parotid gland: report of 126 cases and a review of the literature. Ann Otol Rhinol Laryngol 104:100–104
Piekarski J, Nejc D, Szymczak W, et al. (2004) Results of extracapsular dissection of pleomorphic adenoma of parotid gland. J Oral MaxilloFac Surg 62:1198–1202
Rabinov CR, Canalis RF, Alavi S, et al. (1997) Recurrent pleomorphic adenoma of the parotid gland involving the osseous external auditory canal. Ann Otol Rhinol Laryngol 106:589–593
Rapidis AD, Stavrianos S, Lagogiannia G, et al. (2004) Tumors of the submandibular gland: clinicopathologic analysis of 23 patients. J Oral Maxillofac Surg 62:1203–1208
Renehan A, Gleaves EN, McGurk M (1996) An analysis of the treatment of 114 patients with recurrent pleomorphic adenoma of the parotid gland. Am J Surg 172:710–714
Samson MJ, Metson R, Wang CC, et al. (1991) Preservation of the facial nerve in the management of recurrent pleomorphic adenomas of the parotid gland. Laryngoscope 101:1060–1062
Schot LJ, Hilgers FJM, Keus RB, et al. (1992) Late effects of radiotherapy on hearing. Eur Arch Otorhinolaryngol 249:305–308
Spiro JD, Spiro RH (1994) Submandibular gland tumors. In: Shockley WW (ed) The Neck: Diagnosis and Surgery. Mosby, St Louis, pp 295–306
Stennert E, Guntinas-Lichius O, Klaussmann JP, et al. (2001) Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 cases. Laryngoscope 111:2195–2200
Stennert E, Wittekindt C, Klaussmann JP, et al. (2004) Recurrent pleomorphic adenoma of the parotid gland: a prospective histological and immunohistochemical study. Laryngoscope 114:158–163
Touquet R, McKenzie IJ, Carrouth JAS (1990) Management of the parotid pleomorphic adenoma: the problem of exposing tumor tissue at operation: the logical pursuit of treatment policies. Br J Oral Maxillofac Surg 28:404–408
van der Laan BFAM, Baris G, Gregor RT, et al. (1995) Radiation induced tumors of the head and neck. J Laryngol Otol 109:346–349
Vaughan ED, Richardson D (1993) Facial nerve reconstruction following ablative parotid surgery. Br J Oral Maxillofac Surg 31:274–280
Wai-Hei E, Tsang WM, Tse GMK (2003) Mucoepidermoid carcinoma ex-pleomorphic adenoma of the submandibular gland. Am J Otolaryngol 24:253–257
Waldron CA (1991) Mixed tumor (pleomorphic adenoma) and myoepithelioma. In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical Pathology of the Salivary Glands. Saunders, Philadelphia, pp 165–186
Waldron CA, El-Mofty S, Gnepp DR (1988) Tumors of the intraoral minor salivary glands. Oral Surg Oral Med Oral Pathol 66:323–333
Webb AJ, Eveson JW (2001) Pleomorphic adenomas of the major salivary glands: a study of the capsule form in relation to surgical management. Clin Otolaryngol 26:134–142
Weber RS, Byers RM, Petit B, et al. (1990) Submandibular gland tumors. Arch Otolaryngol Head Neck Surg 116:1055–1060
Witt RL (2002) The significance of the margin in parotid surgery for pleomorphic adenoma. Laryngoscope 112:2141–2154
Yugueros P, Goellner JR, Petty PM, et al. (1998) Treating recurrence of parotid pleomorphic adenoma. Ann Plast Surg 40:573–576
Zabren P, Tschumi I, Nuyens M, et al. (2005) Recurrent pleomorphic adenoma of the parotid gland. Am J Surg 189:203–207
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Bradley, P.J. (2007). Recurrent Pleomorphic Adenoma. In: Myers, E.N., Ferris, R.L. (eds) Salivary Gland Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47072-4_16
Download citation
DOI: https://doi.org/10.1007/978-3-540-47072-4_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-47070-0
Online ISBN: 978-3-540-47072-4
eBook Packages: MedicineMedicine (R0)