Abstract
Over the last few decades, progress in molecular biology and genetics, as well as the development of new experimental approaches, has brought together scientists from all fields. Developmental biologists, geneticists, endocrinologists, and dermatologists now study the many diverse facets of hair follicle biology including neuroectodermal– mesenchymal interactions, immunology, pigmentation, and stem cell biology.
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References
Adolphe C, Narang M, Ellis T et al. (2004) An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 131:5009–5019
Alonso L, Fuchs E (2006) The hair cycle. J Cell Sci 119:391–393
Amoh Y, Li L, Campillo R et al. (2005) Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci U S A 102:17734–17738
Argyris T (1976) Kinetics of epidermal production during epidermal regeneration following abrasion in mice. Am J Pathol 83:329–340
Arnold I, Watt FM (2001) c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 11:558–568
Barman JM, Astore I, Pecoraro V (1965) The normal trichogram of the adult. J Invest Dermatol 44:233–236
Billingham RE (1958) A reconsideration of the phenomenon of hair neogenesis with particular reference to the healing of cutaneous wounds in adult mammals. In: Montagna W, Ellis RA (eds) The biology of hair growth. Academic Press, New York
Blume U, Schon MP, Zouboulis CC et al. (1994) Vellus hair follicle-derived keratinocyte culture: a new experimental model in human hair research. Skin Pharmacol 7:27–32
Breathnach AS, Robins EJ (1981) Ultrastructure of developing hair tract and hair canal in the human fetus. In: Orfanos CE, Montagna W, Stuttgen G (eds) Hair research. Springer Berlin Heidelberg New York
Chambers E (1728) Cyclopaedia, or, an universal dictionary of arts and sciences. Midwinter, London
Christoph T, Muller-Rover S, Audring H et al. (2000) The human hair follicle immune system: cellular composition and immune privilege. Br J Dermatol 142:862–873
Cotsarelis G (2006) Epithelial stem cells: a folliculocentric view. J Invest Dermatol 126:1459–1468
Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329–1337
Courtois M, Loussouarn G, Hourseau S et al. (1996) Periodicity in the growth and shedding of hair. Br J Dermatol 134:47–54
Cui CY, Schlessinger D (2006) EDA signaling and skin appendage development. Cell Cycle 5: 2477–2483
Das BM (1974) A study of cross sections of head hair from some caucasoid and mongoloid populations of Assam, India. Z Morphol Anthropol 65:324–328
Das-Chaudhuri AB, Chopra VP (1984) Variation in hair histological variables: medulla and diameter. Hum Hered 34:217–221
Derham W (1713) Chapter XII, of animals clothing. In: Physico-theology: Or, a demonstration of the being and attributes of god, from his works of creation. W. Innys, London
Ebling FJ (1980) The physiology of hair growth. Cosmetic Science 2:181–232
Elliott K, Stephenson TJ, Messenger AG (1999) Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses. J Invest Dermatol 113:873–877
Ferriman D (1971) Human hair growth in health and disease. Thomas CC Springfield, Illinois
Friedenthal H (1908) Das Dauerhaarkleid des Menschen. Fischer, Jena
Garn SM, Selby S, Young R (1954) Scalp thickness and the fat-loss theory of balding. AMA Arch Derm Syphilol 70:601–608
Gat U, DaGupta R, Degenstein L et al. (1998) De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 95:605–614
Giacometti L (1965) The anatomy of human scalp. Advances in biology of skin. In: Montagna W (ed) Biology of skin, Vol. VI. Pergamon, Oxford
Gilliam AC, Kremer IB, Yoshida Y et al. (1998) The human hair follicle: a reservoir of CD40+ B7-deficient Langerhans cells that repopulate epidermis after UVB exposure. J Invest Dermatol 110:422–427
Gordon MD, Nusse R (2006) Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281:22429–22433
Hardy MK (1969) The differentiation of hair follicles and hairs in organ culture. In: Montagna W, Dobson RL (eds) Advances in biology of skin volume, IX: hair growth. Pergamon, Oxford
Hoffmann R (2001) TrichoScan: combining epiluminescence microscopy with digital image analysis for the measurement of hair growth in vivo. Eur J Dermatol 11:362–368
Holbrook KA, Minami SI (1991) Hair follicle embryogenesis in the human. Characterization of events in vivo and in vitro. Ann N Y Acad Sci 642:167–196
Ito M, Kizawa K, Toyoda M et al. (2002) Label-retaining cells in the bulge region are directed to cell death after plucking, followed by healing from the surviving hair germ. J Invest Dermatol 119:1310–1316
Ito M, Liu Y, Yang Z et al. (2005) Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med 11:1351–1354
Ito T, Ito N, Bettermann A et al. (2004) Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. Am J Pathol 164:623–634
Jahoda CA, Reynolds AJ, Oliver RF (1993) Induction of hair growth in ear wounds by cultured dermal papilla cells. J Invest Dermatol 101:584–590
Kligman AM (1959) The human hair cycle. J Invest Dermatol 33:307–316
Kligman AM (1961) Pathologic dynamics of human hair loss. I. Telogen effuvium. Arch Dermatol 83:175–198
Koch PJ, Mahoney MG, Cotsarelis G et al. (1998) Desmoglein 3 anchors telogen hair in the follicle. J Cell Sci 111 (Pt 17):2529–2537
Kumamoto T, Shalhevet D, Matsue H et al. (2003) Hair follicles serve as local reservoirs of skin mast cell precursors. Blood 102:1654–1660
Lako M, Armstrong L, Cairns PM et al. (2002) Hair follicle dermal cells repopulate the mouse haematopoietic system. J Cell Sci 115:3967–3974
Levy V, Lindon C, Harfe BD et al. (2005) Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell 9:855–861
Loussouarn G, El RC, Genain G (2005) Diversity of hair growth profiles. Int J Dermatol 44 [Suppl 1]:6–9
Matich J, Basford Nicholson LF, Barling PM (2003) Mitotic activity in the growing red deer antler. Cell Biol Int 27:625–632
McElwee KJ, Kissling S, Wenzel E et al. (2003) Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla. J Invest Dermatol 121:1267–1275
McElwee KJ, Yu M, Park SW et al. (2005) What can we learn from animal models of alopecia areata? Dermatology 211:47–53
Mercelot V (1998) Application of a tensile-strength test method to the evaluation of hydrating hair products. Int J Cosmetic Sci 20:241–249
Messenger AG (1984) The culture of dermal papilla cells from human hair follicles. Br J Dermatol 110:685–689
Millar SE (2002) Molecular mechanisms regulating hair follicle development. J Invest Dermatol 118:216–225
Montagna W (1956) The structure and function of skin. Academic Press, New York
Montagna W, Van Scott EJ, The anatomy of the hair follicle. In: Montagna W, Ellia RA (1958) The biology of hair growth, Academic Press, New York
Montagna W, Parakkal PF (1974) The structure and function of skin. Academic Press, New York
Morris RJ (2000) Keratinocyte stem cells: targets for cutaneous carcinogens. J Clin Invest 106:3–8
Morris RJ, Liu Y, Marles L et al. (2004) Capturing and profiling adult hair follicle stem cells. Nat Biotechnol 22:411–417
Muller-Rover S, Handjiski B, van DV et al. (2001) A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 117:3–15
Myers RJ, Hamilton JB (1951) Regeneration and rate of growth of hairs in man. Ann N Y Acad Sci 53:562–568
Nakamura M, Sundberg JP, Paus R (2001) Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables. Exp Dermatol 10:369–390
Narisawa Y, Hashimoto K, Kohda H (1995) Perifollicular clear space under skirt-like epithelial structure of human small vellus hair follicle. J Dermatol Sci 10:110–117
Nishimura EK, Jordan SA, Oshima H et al. (2002) Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416:854–860
Parry DA, Smith TA, Rogers MA et al. (2006) Human hair keratin-associated proteins: sequence regularities and structural implications. J Struct Biol 155:361–369
Paus R, Foitzik K (2004) In search of the “hair cycle clock”: a guided tour. Differentiation 72:489–511
Paus R, Nickoloff BJ, Ito T (2005) A ‘hairy’ privilege. Trends Immunol 26:32–40
Paus R, Theoharides TC, Arck PC (2006) Neuroimmunoendocrine circuitry of the ‘brain-skin connection’. Trends Immunol 27:32–39
Pecoraro V, Astore I, Barman JM (1964) Cycle of the scalp hair of the new-born child. J Invest Dermatol 43:145–147
Pelfini C, Cerimelf D, Pisanu G (1967) Ageing of the skin and hair growth in man. In: Montagna W, Dobson RL (eds) Advances in biology of the skin. Pergamon, Oxford
Peters EM, Arck PC, Paus R (2006) Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control. Exp Dermatol 15:1–13
Philpott MP, Green MR, Kealey T (1992) Rat hair follicle growth in vitro. Br J Dermatol 127:600–607
Pinkus H (1958) Embryology of hair. In: Montagna W, Ellis RA (eds) The biology of hair growth. Academic Press, New York
Randall VA, Sundberg JP, Philpott MP (2003) Animal and in vitro models for the study of hair follicles. J Invest Dermatol Symp Proc 8:39–45
Rebora A, Guarrera M (2002) Kenogen. A new phase of the hair cycle? Dermatology 205:108–110
Reddy S, Andl T, Bagasra A et al. (2001) Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev 107:69–82
Reynolds AJ, Lawrence C, Cserhalmi-Friedman PB et al. (1999) Trans-gender induction of hair follicles. Nature 402:33–34
Rook A (1965) Endocrine influences on hair growth. Br Med J 1:609–614
Rook A (1975) Hair II Racial and other genetic variations in hair form. Br J Dermatol 92:599–600
Rosenblum MD, Yancey KB, Olasz EB et al. (2006) CD200, a “no danger” signal for hair follicles. J Dermatol Sci 41:165–174
Saitoh M, Uzuka M, Sakamoto M (1970) Human hair cycle. J Invest Dermatol 54:65–81
Schmidt-Ullrich R, Paus R (2005) Molecular principles of hair follicle induction and morphogenesis. Bioessays 27:247–261
Schweizer J, Bowden PE, Coulombe PA et al. (2006) New consensus nomenclature for mammalian keratins. J Cell Biol 174:169–174
Schweizer J, Langbein L, Rogers MA et al. (2007) Hair follicle-specific keratins and their diseases. Exp Cell Res Epub ahead of print
Slominski A, Pisarchik A, Tobin DJ et al. (2004) Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology 145:941–950
Slominski A, Wortsman J, Plonka PM et al. (2005) Hair follicle pigmentation. J Invest Dermatol 124:13–21
Stenn KS (2005) Exogen is an active, separately controlled phase of the hair growth cycle. J Am Acad Dermatol 52:374–375
Stenn KS, Paus R (2001) Controls of hair follicle cycling. Physiol Rev 81:449–494
Strumia R, Varotti E, Manzato E et al. (2001) Skin signs in anorexia nervosa. Dermatology 203:314–317
Szabo G (1967) The regional anatomy of the human integument with special reference to the distribution of hair follicles, sweat glands and melanocytes. Philos Trans R Soc Lond Series B Biol Sci 252:447–485
Thomas JA, Biggerstaff M, Sloane JP et al. (1984) Immunological and histochemical analysis of regional variations of epidermal Langerhans cells in normal human skin. Histochem J 16:507–519
Trotter M (1924) The life cycles of hair in selected regions of the dody. Am J Phys Anthropol 7:427–437
Uchigasaki S, Suzuki H, Inoue K (2004) Merkel cells in the vellus hair follicles of human facial skin: a study using confocal laser microscopy. J Dermatol 31:218–222
Van Scott EJ, Reinertson RP, Steinmueller R (1957) The growing hair roots of the human scalp and morphologic changes therein following amethopterin therapy. J Invest Dermatol 29:197–204
Von Koelliker RA (1852) Handbuch der Gewebelehre des Menschen. Engelmann, Leipzig
Watt FM (1998) Epidermal stem cells: markers, patterning and the control of stem cell fate. Philos Trans R Soc Lond Series B Biol Sci 353:831–837
Wolfram L (2003) Human hair: a unique physicochemical composite. J Am Acad Dermatol 48:S106–S114
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Vogt, A., McElwee, K., Blume-Peytavi, U. (2008). Biology of the Hair Follicle. In: Blume-Peytavi, U., Tosti, A., Trüeb, R. (eds) Hair Growth and Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46911-7_1
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DOI: https://doi.org/10.1007/978-3-540-46911-7_1
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