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Genetic Analysis of Eye Development in Zebrafish

  • Chapter
Vertebrate Eye Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 31))

Abstract

The vertebrate eye is a remarkable biological sensor which provides an extraordinary assortment of detailed information about the surrounding world. The accurate performance of the eye requires the cooperation of many elements with fundamentally different functional and structural properties such as the lens, ocular muscles, and the retina. The embryological origins of the eye are as diverse as its structure. The neural retina and the pigmented epithelium originate as an outpocketing of the neural tube, the lens as an ectodermal placode, while the ocular muscles arise from the mesenchyme. In the past decade or so, a small aquatic vertebrate, the zebrafish, has emerged as an excellent model system to study the genetic basis of vertebrate eye development.

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References

  • Adelmann HB (1930) Experimental studies of the development of the eye. III. J Exp Zool 57 : 223–281

    Article  Google Scholar 

  • Allende ML, Amsterdam A, Becker T, Kawakami K, Gaiano N, Hopkins N (1996) Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. Genes Dev 10 : 3141–3155

    Article  PubMed  CAS  Google Scholar 

  • Allwardt B (1999) Ultrastructural analysis of photoreceptors in wild-type and mutant zebrafish larvae. Ph.D. thesis, Harvard University, Cambridge, Massachusetts

    Google Scholar 

  • Altshuler D, Turner D, Cepko C (1991) Specification of cell type in the vertebrate retina. In : Man-Kit Lam D and Shatz C (eds) Development of the Visual System. The MIT Press, Cambridge, Massachusetts, pp 37–58

    Google Scholar 

  • Amsterdam A, Hopkins N (1999) Retrovirus-mediated insertional mutagenesis in zebrafish. Methods Cell Biol 60 : 87–98

    Article  PubMed  CAS  Google Scholar 

  • Baier H, Klostermann S, Trowe T, Karlstrom RO, Nusslein-Volhard C, Bonhoeffer F (1996) Genetic dissection of the retinotectal projection. Development 123 : 415–425

    PubMed  CAS  Google Scholar 

  • Beattie CE, Raible DW, Henion PD, Eisen JS (1999) Early pressure screens. Methods Cell Biol 60:71–86

    Article  PubMed  CAS  Google Scholar 

  • Becker TS, Burgess SM, Amsterdam AH, Allende ML, Hopkins N (1998) not really finished is crucial for development of the zebrafish outer retina and encodes a transcription factor highly homologous to human Nuclear Respiratory Factor-1 and avian Initiation Binding Repressor. Development 125 : 4369–4378

    PubMed  CAS  Google Scholar 

  • Bodick N, Levinthal C (1980) Growing optic nerve fibers follow neighbors during embryogenesis. Proc Natl Acad Sci USA 77 : 4374–4378

    Article  PubMed  CAS  Google Scholar 

  • Branchek T, Bremiller R (1984) The Development of Photoreceptors in the Zebrafish, Brachydanio rerio. I. Structure. J Comp Neurol 224 : 107–115

    Article  PubMed  CAS  Google Scholar 

  • Brand M, Heisenberg CP, Jiang YJ, Beuchle D, Lun K, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane DA, Kelsh RN, Mullins MC, Odenthal J, van Eeden FJ, Nusslein Volhard C (1996a) Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development 123 : 179–190

    PubMed  CAS  Google Scholar 

  • Brand M, Heisenberg CP, Warga RM, Pelegri F, Karlstrom RO, Beuchle D, Picker A, Jiang YJ, Furutani-Seiki M, van Eeden FJ, Granato M, Haffter P, Hammerschmidt M, Kane DA, Kelsh RN, Mullins MC, Odenthal J, Nusslein-Volhard C (1996b) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development 123 : 129–142

    PubMed  CAS  Google Scholar 

  • Brockerhoff SE, Dowling JE, Hurley JB (1998) Zebrafish retinal mutants. Vision Res 38 : 1335–1339

    Article  PubMed  CAS  Google Scholar 

  • Brockerhoff SE, Hurley JB, Janssen-Bienhold U, Neuhauss SC, Driever W, Dowling JE (1995) A behavioral screen for isolating zebrafish mutants with visual system defects. Proc Natl Acad Sci USA 92 : 10545–10549

    Article  PubMed  CAS  Google Scholar 

  • Brockerhoff SE, Hurley JB, Niemi GA, Dowling JE (1997) A new form of inherited red-blindness identified in zebrafish. J Neurosci 17 : 4236–4242

    PubMed  CAS  Google Scholar 

  • Brownlie A, Donovan A, Pratt SJ, Paw BH, Oates AC, Brugnara C, Witkowska HE, Sassa S, Zon LI (1998) Positional cloning of the zebrafish sauternes gene : a model for congenital sideroblastic anaemia. Nat Genet 20 : 244–250

    Article  PubMed  CAS  Google Scholar 

  • Burmeister M, Novak J, Liang MY, Basu S, Ploder L, Hawes NL, Vidgen D, Hoover F, Goldman D, Kalnins VI, Roderick TH, Taylor BA, Hankin MH, McInnes RR (1996) Ocular retardation mouse caused by Chx10 homeobox null allele : impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 12 : 376–384

    Article  PubMed  CAS  Google Scholar 

  • Burrill J, Easter S (1995) The first retinal axons and their microenvironment in zebrafish cryptic pioneers and the pretract. J Neurosci 15 : 2935–2947

    PubMed  CAS  Google Scholar 

  • Burrill JD, Easter SS, Jr. (1994) Development of the retinofugal projections in the embryonic and larval zebrafish (Brachydanio rerio). J Comp Neurol 346 : 583–600

    Article  PubMed  CAS  Google Scholar 

  • Cajal SR (1893) La retine des vertebres. La Cellule 9 : 17–257

    Google Scholar 

  • Chen JN, Haffter P, Odenthal J, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA, Kelsh RN, Mullins MC, Nusslein Volhard C (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123 : 293–302

    PubMed  CAS  Google Scholar 

  • Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407–413

    Article  PubMed  CAS  Google Scholar 

  • Chien C, Bonhoeffer F (1997) Zebrafish retinotectal pathfinding mutants projecting to extratectal targets. Soc Neurosci Abstr 23 : 604

    Google Scholar 

  • Clark T (1981) Visual responses in developing zebrafish (Brachydanio rerio). PhD Thesis, University of Oregon, Eugene, Oregon

    Google Scholar 

  • Corley-Smith GE, Lim CJ, Brandhorst BP (1996) Production of androgenetic zebrafish (Danio rerio). Genetics 142 : 1265–1276

    PubMed  CAS  Google Scholar 

  • Dowling J (1987) The Retina. Harvard University Press, Cambridge, Massachusetts

    Google Scholar 

  • Driever W, Solnica-Krezel L, Schier AF, Neuhauss SC, Malicki J, Stemple DL, Stainier DY, Zwartkruis F, Abdelilah S, Rangini Z, Belak J, Boggs C (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development 123 : 37–46

    PubMed  CAS  Google Scholar 

  • Drummond IA, Majumdar A, Hentschel H, Elger M, Solnica-Krezel L, Schier AF, Neuhauss SC, Stemple DL, Zwartkruis F, Rangini Z, Driever W, Fishman MC (1998) Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development 125 : 4655–4667

    PubMed  CAS  Google Scholar 

  • Easter S, Nicola G (1996) The development of vision in the zebrafish (Danio rerio). Dev Biol 180 : 646–663

    Article  PubMed  CAS  Google Scholar 

  • Fadool JM, Brockerhoff SE, Hyatt GA, Dowling JE (1997) Mutations affecting eye morphology in the developing zebrafish (Danio rerio). Dev Genet 20 : 288–295

    Article  PubMed  CAS  Google Scholar 

  • Fadool JM, Hartl DL, Dowling JE (1998) Transposition of the mariner element from Drosophila mauritiana in zebrafish. Proc Natl Acad Sci USA 95 : 5182–5186

    Article  PubMed  CAS  Google Scholar 

  • Fekany K, Yamanaka Y, Leung T, Sirotkin HI, Topczewski J, Gates MA, Hibi M, Renucci A, Stemple D, Radbill A, Schier AF, Driever W, Hirano T, Talbot WS, Solnica-Krezel L (1999) The zebrafish bozozok locus encodes dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development 126 : 1427–1438

    PubMed  CAS  Google Scholar 

  • Feldman B, Gates MA, Egan ES, Dougan ST, Rennebeck G, Sirotkin HI, Schier AF, Talbot WS (1998) Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature 395 : 181–185

    Article  PubMed  CAS  Google Scholar 

  • Fujisawa H (1971) A complete reconstruction of the neural retina of chick embryo grafted onto the chorio-allantoic membrane. Dev Growth Differ (Nagoya) 13 : 25–36

    Article  CAS  Google Scholar 

  • Fulwiler C, Schmitt EA, Kim JM, Dowling JE (1997) Retinal patterning in the zebrafish mutant cyclops. J Comp Neurol 381 : 449–460

    Article  PubMed  CAS  Google Scholar 

  • Gaiano N, Allende M, Amsterdam A, Kawakami K, Hopkins N (1996a) Highly efficient germline transmission of proviral insertions in zebrafish. Proc Natl Acad Sci USA 93 : 7777–7782

    Article  PubMed  CAS  Google Scholar 

  • Gaiano N, Amsterdam A, Kawakami K, Allende M, Becker T, Hopkins N (1996b) Insertional mutagenesis and rapid cloning of essential genes in zebrafish. Nature 383 : 829–832

    Article  PubMed  CAS  Google Scholar 

  • Gan L, Xiang M, Zhou L, Wagner DS, Klein WH, Nathans J (1996) POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci USA 93:3920–3925

    Article  PubMed  CAS  Google Scholar 

  • Georges-Labouesse E, Mark M, Messaddeq N, Gansmuller A (1998) Essential role of alpha 6 integrins in cortical and retinal lamination. Curr Biol 8 : 983–986

    Article  PubMed  CAS  Google Scholar 

  • Grunwald DJ, Kimmel CB, Westerfield M, Walker C, Streisinger G (1988) A neural degeneration mutation that spares primary neurons in the zebrafish. Dev Biol 126 : 115–128

    Article  PubMed  CAS  Google Scholar 

  • Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W, Rosenthal A (1999) Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol 208 : 473–487

    Article  PubMed  CAS  Google Scholar 

  • Haffter P, Granato M, Brand M, Mullins MC, Hammerschmidt M, Kane DA, Odenthal J, van Eeden FJ, Jiang YJ, Heisenberg CP, Kelsh RN, Furutani-Seiki M, Vogelsang E, Beuchle D, Schach U, Fabian C, Nusslein-Volhard C (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123 : 1–36

    PubMed  CAS  Google Scholar 

  • Hatta K, Puschel AW, Kimmel CB (1994) Midline signaling in the primordium of the zebrafish anterior central nervous system. Proc Natl Acad Sci USA 91 : 2061–2065

    Article  PubMed  CAS  Google Scholar 

  • Heisenberg CP, Brand M, Jiang YJ, Warga R, Beuchle D, Eeden F, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Nusslein-Volhard C (1996) Genes involved in forebrain development in the zebrafish, Danio rerio. Development 123 : 191–203

    PubMed  CAS  Google Scholar 

  • Heisenberg CP, Nusslein-Volhard C (1997) The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Dev Biol 184 : 85–94

    Article  PubMed  CAS  Google Scholar 

  • Henion PD, Raible DW, Beattie CE, Stoesser KL, Weston JA, Eisen JS (1996) Screen for mutations affecting development of Zebrafish neural crest. Dev Genet 18 :11–17

    Article  PubMed  CAS  Google Scholar 

  • Hill Rea (1991) Mouse Small eye results from mutations in a paired-like homeobox-containing gene. Nature 354 : 522–525

    Article  Google Scholar 

  • Hu M, Easter SS (1999) Retinal neurogenesis : the formation of the initial central patch of postmitotic cells. Dev Biol 207 : 309–321

    Article  PubMed  CAS  Google Scholar 

  • Johns PR, Fernald RD (1981) Genesis of rods in teleost fish retina. Nature 293 : 141–142

    Article  PubMed  CAS  Google Scholar 

  • Karlstrom RO, Talbot WS, Schier AF (1999) Comparative synteny cloning of zebrafish you-too : mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Genes Dev 13 : 388–393

    Article  PubMed  CAS  Google Scholar 

  • Karlstrom RO, Trowe T, Bonhoeffer F (1997) Genetic analysis of axon guidance and mapping in the zebrafish. Trends Neurosci 20 : 3–8

    Article  PubMed  CAS  Google Scholar 

  • Karlstrom RO, Trowe T, Klostermann S, Baier H, Brand M, Crawford AD, Grunewald B, Haffter P, Hoffmann H, Meyer SU, Muller BK, Richter S, van Eeden FJ, Nusslein-Volhard C, Bonhoeffer F (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development 123 : 427–438

    PubMed  CAS  Google Scholar 

  • Kelsh RN, Brand M, Jiang YJ, Heisenberg CP, Lin S, Haffter P, Odenthal J, Mullins MC, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Kane DA, Warga RM, Beuchle D, Vogelsang L, Nusslein-Volhard C (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development 123 : 369–389

    PubMed  CAS  Google Scholar 

  • Knapik EW, Goodman A, Ekker M, Chevrette M, Delgado J, Neuhauss S, Shimoda N, Driever W, Fishman MC, Jacob HJ (1998) A microsatellite genetic linkage map for zebrafish (Danio rerio). Nat Genet 18 : 338–343

    Article  PubMed  CAS  Google Scholar 

  • Kwok C, Korn RM, Davis ME, Burt DW, Critcher R, McCarthy L, Paw BH, Zon LI, Goodfellow PN, Schmitt K (1998) Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. Nucleic Acids Res 26 : 3562–3566

    Article  PubMed  CAS  Google Scholar 

  • Larison K, Bremiller R (1990) Early onset of phenotype and cell patterning in the embryonic zebrafish retina. Development 109 : 567–576

    PubMed  CAS  Google Scholar 

  • Li H, Tierney C, Wen L, Wu JY, Rao Y (1997) A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. Development 124 : 603–615

    PubMed  CAS  Google Scholar 

  • Li L, Dowling JE (1997) A dominant form of inherited retinal degeneration caused by a nonphotoreceptor cell-specific mutation. Proc Natl Acad Sci USA 94 : 11645–11650

    Article  PubMed  CAS  Google Scholar 

  • Lin S, Gaiano N, Culp P, Burns JC, Friedmann T, Yee JK, Hopkins N (1994) Integration and germ-line transmission of a pseudotyped retroviral vector in zebrafish. Science 265 : 666–669

    Article  PubMed  CAS  Google Scholar 

  • Lun K, Brand M (1998) A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary. Development 125 : 3049–3062

    PubMed  CAS  Google Scholar 

  • Macdonald R, Barth KA, Xu Q, Holder N, Mikkola I, Wilson SW (1995) Midline signalling is required for Pax gene regulation and patterning of the eyes. Development 121 : 3267–3278

    PubMed  CAS  Google Scholar 

  • Macdonald R, Scholes J, Strahle U, Brennan C, Holder N, Brand M, Wilson SW (1997) The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain. Development 124 : 2397–2408

    PubMed  CAS  Google Scholar 

  • Malicki J (1999) Development of the retina. Methods Cell Biol 59 : 273–299

    Article  PubMed  CAS  Google Scholar 

  • Malicki J, Driever W (1999) oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet. Development 126 : 1235–1246

    PubMed  CAS  Google Scholar 

  • Malicki J, Neuhauss SC, Schier AF, Solnica-Krezel L, Stemple DL, Stainier DY, Abdelilah S, Zwartkruis F, Rangini Z, Driever W (1996a) Mutations affecting development of the zebrafish retina. Development 123 : 263–273

    PubMed  CAS  Google Scholar 

  • Malicki J, Schier AF, Solnica-Krezel L, Stemple DL, Neuhauss SC, Stainier DY, Abdelilah S, Rangini Z, Zwartkruis F, Driever W (1996b) Mutations affecting development of the zebrafish ear. Development 123 : 275–283

    PubMed  CAS  Google Scholar 

  • Marcus RC, Delaney CL, Easter SS, Jr. (1999) Neurogenesis in the visual system of embryonic and adult zebrafish (Danio rerio). Vis Neurosci 16 : 417–424

    Article  PubMed  CAS  Google Scholar 

  • Marlow F, Zwartkruis F, Malicki J, Neuhauss SC, Abbas L, Weaver M, Driever W, Solnica-Krezel L (1998) Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish. Dev Biol 203 : 382–399

    Article  PubMed  CAS  Google Scholar 

  • Marsh-Armstrong N, McCaffery P, Gilbert W, Dowling JE, Drager UC (1994) Retinoic acid is necessary for development of the ventral retina in zebrafish. Proc Natl Acad Sci USA 91 :7286–7290

    Article  PubMed  CAS  Google Scholar 

  • Mascrez B, Mark M, Dierich A, Ghyselinck NB, Kastner P, Chambon P (1998) The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development. Development 125 : 4691–4707

    PubMed  CAS  Google Scholar 

  • Mathers PH, Grinberg A, Mahon KA, Jamrich M (1997) The Rx homeobox gene is essential for vertebrate eye development. Nature 387 : 603–607

    Article  PubMed  CAS  Google Scholar 

  • Moens CB, Cordes SP, Giorgianni MW, Barsh GS, Kimmel CB (1998) Equivalence in the genetic control of hindbrain segmentation in fish and mouse. Development 125 : 381–391

    PubMed  CAS  Google Scholar 

  • Muller H (1857) Anatomisch-physiologische untersuchungen uber die Retina bei Menschen und Wirbelthieren. Z Wiss Zool 8 : 1–122

    Google Scholar 

  • Mullins MC, Hammerschmidt M, Haffter P, Nusslein-Volhard C (1994) Large-scale mutagenesis in the zebrafish : in search of genes controlling development in a vertebrate. Curr Biol 4 : 189–202

    Article  PubMed  CAS  Google Scholar 

  • Nawrocki W (1985) Development of the neural retina in the zebrafish, Brachydanio rerio. PhD Thesis, University of Oregon, Eugine, Oregon

    Google Scholar 

  • Nornes S, Clarkson M, Mikkola I, Pedersen M, Bardsley A, Martinez JP, Krauss S, Johansen T (1998) Zebrafish contains two pax6 genes involved in eye development. Mech Dev 77 :185–196

    Article  PubMed  CAS  Google Scholar 

  • Odenthal J, Haffter P, Vogelsang E, Brand M, van Eeden FJ, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA, Kelsh RN, Mullins MC, Warga RM, Allende ML, Weinberg ES, Nusslein-Volhard C (1996) Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development 123 : 103–115

    PubMed  CAS  Google Scholar 

  • Passini MA, Levine EM, Canger AK, Raymond PA, Schechter N (1997) Vsx-1 and Vsx-2 : differential expression of two paired-like homeobox genes during zebrafish and goldfish retinogenesis. J Comp Neurol 388 : 495–505

    Article  PubMed  CAS  Google Scholar 

  • Pelegri F, Schulte-Merker S (1999) A gynogenesis-based screen for maternal-effect genes in the zebrafish, Danio rerio. Methods Cell Biol 60 : 1–20

    Article  PubMed  CAS  Google Scholar 

  • Pfeffer PL, Gerster T, Lun K, Brand M, Busslinger M (1998) Characterization of three novel members of the zebrafish Pax2/5/8 family : dependency of pax5 and pax8 expression on the pax2.1 (noi) function. Development 125 : 3063–3074

    PubMed  CAS  Google Scholar 

  • Piotrowski T, Schilling TF, Brand M, Jiang YJ, Heisenberg CP, Beuchle D, Grandel H, van Eeden FJ, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane DA, Kelsh RN, Mullins MC, Odenthal J, Warga RM, Nusslein-Volhard C (1996) Jaw and branchial arch mutants in zebrafish II : anterior arches and cartilage differentiation. Development 123 : 345–356

    PubMed  CAS  Google Scholar 

  • Porter FD, Drago J, Xu Y, Cheema SS, Wassif C, Huang SP, Lee E, Grinberg A, Massalas JS, Bodine D, Alt F, Westphal H (1997) Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development 124 : 2935–2944

    PubMed  CAS  Google Scholar 

  • Raymond P, Barthel L, Curran G (1995) Developmental patterning of rod and cone photoreceptors in embryonic zebrafish. J Comp Neurol 359 : 537–550

    Article  PubMed  CAS  Google Scholar 

  • Raymond P, Barthel L, Rounsifer M, Sullivan S, Knight J (1993) Expression of rod and cone visual pigments in godfish and zebrafish : A rhodopsin-like gene is expressed in cones. Neuron 10 : 1161–1174

    Article  PubMed  CAS  Google Scholar 

  • Raz E, van Luenen HG, Schaerringer B, Plasterk RHA, Driever W (1998) Transposition of the nematode Caenorhabditis elegans Tc3 element in the zebrafish Danio rerio. Curr Biol 8 : 82–88

    Article  PubMed  CAS  Google Scholar 

  • Reifers F, Bohli H, Walsh EC, Crossley PH, Stainier DY, Brand M (1998) Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development 125:2381–2395

    PubMed  CAS  Google Scholar 

  • Robinson J, Schmitt E, Dowling J (1995) Temporal and spatial patterns of opsin gene expression in zebrafish (Danio rerio). Visual Neuroscience 12 : 895–906

    Article  PubMed  CAS  Google Scholar 

  • Rodieck RW (1973) The vertebrate retina. Principles of structure and function. W. H. Freeman & Co, San Francisco, California

    Google Scholar 

  • Roessler E, Belloni E, Gaudenz K, Jay P, Berta P, Scherer SW, Tsui LC, Muenke M (1996) Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet 14 : 357–360

    Article  PubMed  CAS  Google Scholar 

  • Sampath K, Rubinstein AL, Cheng AM, Liang JO, Fekany K, Solnica-Krezel L, Korzh V, Halpern ME, Wright CV (1998) Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature 395 : 185–189

    Article  PubMed  CAS  Google Scholar 

  • Schauerte HE, van Eeden FJ, Fricke C, Odenthal J, Strahle U, Haffter P (1998) Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development 125:2983–2993

    PubMed  CAS  Google Scholar 

  • Scheer N, Campos-Ortega JA (1999) Use of the Ga14-UAS technique for targeted gene expression in the zebrafish. Mech Dev 80 : 153–158

    Article  PubMed  CAS  Google Scholar 

  • Schier AF, Neuhauss SC, Harvey M, Malicki J, Solnica-Krezel L, Stainier DY, Zwartkruis F, Abdelilah S, Stemple DL, Rangini Z, Yang H, Driever W (1996) Mutations affecting the development of the embryonic zebrafish brain. Development 123 : 165–178

    PubMed  CAS  Google Scholar 

  • Schier AF, Neuhauss SC, Helde KA, Talbot WS, Driever W (1997) The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail. Development 124 : 327–342

    PubMed  CAS  Google Scholar 

  • Schilling TF, Piotrowski T, Grandel H, Brand M, Heisenberg CP, Jiang YJ, Beuchle D, Hammerschmidt M, Kane DA, Mullins MC, van Eeden FJ, Kelsh RN, Furutani-Seiki M, Granato M, Haffter P, Odenthal J, Warga RM, Trowe T, Nusslein-Volhard C (1996) Jaw and branchial arch mutants in zebrafish I : branchial arches. Development 123 : 329–344

    PubMed  CAS  Google Scholar 

  • Schmitt E, Dowling J (1994) Early eye morphogenesis in the Zebrafish, Brachydanio rerio. J of Comp Neurol 344 : 532–542

    Article  CAS  Google Scholar 

  • Schmitt EA, Dowling JE (1996) Comparison of topographical patterns of ganglion and photoreceptor cell differentiation in the retina of the zebrafish, Danio rerio. J Comp Neurol 371:222–234

    Article  PubMed  CAS  Google Scholar 

  • Sheffield J, Moscona A (1970) Electron microscopic analysis of aggregation of embryonic cells : the structure and differentiation of aggregates of neural retina cells. Dev Biol 23 : 36–61

    Article  PubMed  CAS  Google Scholar 

  • Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ, Weinberg RA (1995) Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82 : 621–630

    Article  PubMed  CAS  Google Scholar 

  • Solnica-Krezel L, Schier A, Driever W (1994) Efficient recovery of ENU-induced mutations from the zebrafish germline. Genetics 136 : 1–20

    Google Scholar 

  • Solnica-Krezel L, Stemple DL, Mountcastle-Shah E, Rangini Z, Neuhauss SC, Malicki J, Schier AF, Stainier DY, Zwartkruis F, Abdelilah S, Driever W (1996) Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development 123 : 67–80

    PubMed  CAS  Google Scholar 

  • Stemple DL, Solnica-Krezel L, Zwartkruis F, Neuhauss SC, Schier AF, Malicki J, Stainier DY, Abdelilah S, Rangini Z, Mountcastle-Shah E, Driever W (1996) Mutations affecting development of the notochord in zebrafish. Development 123 : 117–128

    PubMed  CAS  Google Scholar 

  • Streisinger G, Coale F, Taggart C, Walker C, Grunwald DJ (1989) Clonal origins of cells in the pigmented retina of the zebrafish eye. Dev Biol 131 : 60–69

    Article  PubMed  CAS  Google Scholar 

  • Stuermer CA (1988) Retinotopic organization of the developing retinotectal projection in the zebrafish embryo. J Neurosci 8:4513–4530

    PubMed  CAS  Google Scholar 

  • Stumpo D, Bock C, Tuttle J, Blackshear P (1995) MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc Natl Acad Sci USA 92 : 944–948

    Article  PubMed  CAS  Google Scholar 

  • Talbot WS, Trevarrow B, Halpern ME, Melby AE, Farr G, Postlethwait JH, Jowett T, Kimmel CB, Kimelman D (1995) A homeobox gene essential for zebrafish notochord development. Nature 378 : 150–157

    Article  PubMed  CAS  Google Scholar 

  • Tomasiewicz H (1993) Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central neuvous system. Neuron 11 : 1163–1174

    Article  PubMed  CAS  Google Scholar 

  • Tomita K, Ishibashi M, Nakahara K, Ang SL, Nakanishi S, Guillemot F, Kageyama R (1996) Mammalian hairy and Enhancer of split homolog 1 regulates differentiation of retinal neurons and is essential for eye morphogenesis. Neuron 16 : 723–734

    Article  PubMed  CAS  Google Scholar 

  • Trowe T, Klostermann S, Baier H, Granato M, Crawford AD, Grunewald B, Hoffmann H, Karlstrom RO, Meyer SU, Muller B, Richter S, Nusslein-Volhard C, Bonhoeffer F (1996) Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development 123 : 439–450

    PubMed  CAS  Google Scholar 

  • van Eeden F, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Allende M, Weinberg E, Nusslein-Volhard C (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Dev Suppl 123 : 153–164

    Google Scholar 

  • van Eeden FJ, Granato M, Odenthal J, Haffter P (1999) Developmental mutant screens in the zebrafish. Methods Cell Biol 60 : 21–41

    Article  PubMed  Google Scholar 

  • Vihtelic TS, Doro CJ, Hyde DR (1999) Cloning and characterization of six zebrafish photoreceptor opsin cDNAs and immunolocalization of their corresponding proteins. Vis Neurosci 16:571–585

    Article  PubMed  CAS  Google Scholar 

  • Virbasius CA, Virbasius JV, Scarpulla RC (1993) NRF-1, an activator involved in nuclearmitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes Dev 7: 2431–2445

    Article  PubMed  CAS  Google Scholar 

  • Walker C (1999) Haploid screens and gamma-ray mutagenesis. Methods Cell Biol 60 : 43–70

    Article  PubMed  CAS  Google Scholar 

  • Weinstein BM, Stemple DL, Driever W, Fishman MC (1995) Gridlock, a localized heritable vascular patterning defect in the zebrafish. Nat Med 1 : 1143–1147

    Article  PubMed  CAS  Google Scholar 

  • Whitfield TT, Granato M, van Eeden FJ, Schach U, Brand M, Furutani-Seiki M, Haffter P, Hammerschmidt M, Heisenberg CP, Jiang YJ, Kane DA, Kelsh RN, Mullins MC, Odenthal J, Nusslein-Volhard C (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development 123 : 241–254

    PubMed  CAS  Google Scholar 

  • Woo K, Fraser SE (1995) Order and coherence in the fate map of the zebrafish nervous system. Development 121 : 2595–2609

    PubMed  CAS  Google Scholar 

  • Yamanaka Y, Mizuno T, Sasai Y, Kishi M, Takeda H, Kim CH, Hibi M, Hirano T (1998) A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Genes Dev 12:2345–2353

    Article  PubMed  CAS  Google Scholar 

  • Zhang J, Talbot WS, Schier AF (1998) Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation. Cell 92 : 241–251

    Article  PubMed  CAS  Google Scholar 

  • Zhong TP, Kaphingst K, Akella U, Haldi M, Lander ES, Fishman MC (1998) Zebrafish genomic library in yeast artificial chromosomes. Genomics 48 : 136–138

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Dept. of Ophthalmology, Harvard Medical School/MEEI, 243 Charles St., Boston, Massachusetts, 02114, USA

    Jarema Malicki

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  1. Jarema Malicki
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  1. Vision Research Laboratories, New England Eye Center, Tufts University School of Medicine, 750 Washington Street, Box 450, Boston, MA, 02111, USA

    M. Elizabeth Fini Ph. D.

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© 2000 Springer-Verlag Berlin Heidelberg

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Malicki, J. (2000). Genetic Analysis of Eye Development in Zebrafish. In: Fini, M.E. (eds) Vertebrate Eye Development. Results and Problems in Cell Differentiation, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46826-4_13

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  • DOI: https://doi.org/10.1007/978-3-540-46826-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-53678-6

  • Online ISBN: 978-3-540-46826-4

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