• Caroline Brennan
  • Sharon L. Amacher
  • Peter D. Currie
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 40)


Segmentation, the subdivision of the body into morphologically similar units along its axis, is a fundamental mechanism used to establish embryonic organization and form. The segmental nature of vertebrate development is evident in the formation and organization of the hindbrain, the branchial arches, mesoderm and peripheral nervous system. Here we review somitogenesis, the formation and subsequent differentiation of the segmental units of the mesoderm, in zebrafish and relate it to similar processes in higher vertebrates. For recent reviews of somitogenesis in amniotes and discussion of general mechanisms of somite formation, see also Gossler and Hrabe de Angelis (1998), Pourquie (2000) and Rawls et al. (2000).


Notch Signaling Mutant Embryo Zebra Fish Paraxial Mesoderm Presomitic Mesoderm 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Caroline Brennan
    • 1
  • Sharon L. Amacher
    • 2
  • Peter D. Currie
    • 3
  1. 1.School of Biological Sciences, Queen Mary CollegeUniversity of LondonLondonUK
  2. 2.Department of Molecular and Cell Biology, 555 Life Sciences Addition #3200University of California, BerkeleyBerkeleyUSA
  3. 3.Developmental Genetics Section, MRC Human Genetics UnitWestern General HospitalEdinburghUK

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