Neurogenesis and Specification of Neuronal Identity

  • Bruce Appel
  • Ajay Chitnis
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 40)


Neural development unfolds with remarkable speed in zebrafish embryos where early neurons extend axons in a cell-specific pattern by the first day of development and a functional, though still growing, nervous system permits free-living larvae to hatch from their chorion shells by the second day of development. The relative simplicity of the early nervous system in zebrafish make it attractive to explore mechanisms that determine how specific types of neurons and glia are made in the correct number and location. In this chapter, we will first briefly describe the organization of different cell types in the early zebrafist nervous system and then discuss mechanisms responsible for establishing their organization. Since an exhaustive description of the anatomy and neurogenesis in the entire neural tube would be beyond the scope of this book, we will emphasize studies related to the development of the spinal cors.


Motor Neuron Neural Plate Floor Plate Zebra Fish Proneural Gene 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Bruce Appel
    • 1
  • Ajay Chitnis
    • 2
  1. 1.Department of Biological SciencesVanderbilt UniversityNashvilleUSA
  2. 2.Unit of Vertebrate Neural DevelopmentNIH/NICHD Laboratory of Molecular GeneticsBethesdaUSA

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