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Role of Immediate Early Gene Expression in Cortical Morphogenesis and Plasticity

  • Chapter
Cortical Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 39))

Summary

During the development of the central nervous system, there is a fundamental requirement for synaptic activity in transforming immature neuronal connections into organized functional circuits (Katz 1996). The molecular mechanisms underlying activity-dependent adaptive changes in neurons are believed to involve regulated cascades of gene expression. Immediate early genes (IEGs) comprise the initial cascade of gene expression responsible for initiating the process of stimulus-induced adaptive change, and were identified initially as transcription factors that were regulated in brain by excitatory synaptic activity. More recently, a class of neuronal immediate early genes has been identified that encodes growth factors, signaling molecules, extracellular matrix and adhesion proteins, and cytoskeletal proteins that are rapidly and transiently expressed in response to glutamatergic neurotransmission. This review focuses on the neuronal immediate early gene (nIEG) response, in particular, the class of “effector” immediate early gene proteins that may directly modify neuronal and synaptic function.

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Authors and Affiliations

  1. Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Meyer 5-119B, Baltimore, Maryland, 21205, USA

    Katrin I. Andreasson

  2. Departments of Neurology, Neuroscience, Pathology, Pediatrics, Psychiatry and Behavioral Studies, and Radiological Science, Johns Hopkins University School of Medicine and the Kennedy Krieger Institute, 600 N. Wolfe Street, Meyer 5-119B, Baltimore, Maryland, 21205, USA

    Walter E. Kaufmann

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  1. Department of Biology, Morgan State University, Cold Spring Lane and Hillen Road, Baltimore, MD, 21251, USA

    Christine Hohmann

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Andreasson, K.I., Kaufmann, W.E. (2002). Role of Immediate Early Gene Expression in Cortical Morphogenesis and Plasticity. In: Hohmann, C. (eds) Cortical Development. Results and Problems in Cell Differentiation, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46006-0_6

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