Regulated Nuclear Transport
The regulated traffic of cargoes between nucleus and cytoplasm is now thought rather to be the rule than the exception in nuclear transport. The biological importance of regulated nuclear transport is intuitively suggestive. A fast transcriptional response may be produced by rapid nuclear import of a transcription factor. Backtransfer to the cytoplasm would cease transcriptional output and the factor can be re-used. This picture is oversimplified as only few thorough studies exist. It remains to be clarified how far regulation of nuclear transport contributes to cellular signal transduction and control of its downstream targets.
KeywordsNuclear Localization Signal Fission Yeast Nuclear Export Nuclear Import Nuclear Accumulation
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