Nuclear Export of Messenger RNA

  • Elisa Izaurralde
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 35)


Messenger RNAs (mRNAs) exist in the cell in dynamic association with multiple distinct proteins. The mRNA export cargo is therefore a ribonucleoprotein particle (mRNP). The most striking example of this are the Balbiani ring (BR) mRNPs of Chironomus tentans which are composed of an RNA molecule of 35–40 kb in length associated with about 500 protein molecules (Mehlin et al. 1992; reviewed by Daneholt 1997). Among the most abundant RNA-binding proteins found associated to heterogeneous (in size) nuclear mRNPs are the hnRNP proteins. There are about 20 different hnRNP proteins in higher eukaryotes (hnRNP A to hnRNP U, reviewed by Dreyfuss et al. 1993).


Nuclear Export Nuclear Pore Complex mRNA Export Balbiani Ring hnRNP Protein 
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© Springer-Verlag Berlin Heidelberg 2002 2002

Authors and Affiliations

  • Elisa Izaurralde
    • 1
  1. 1.EMBLHeidelbergGermany

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