Simultaneous Population Based Image Alignment for Template Free Spatial Normalisation of Brain Anatomy

  • C. Studholme
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2717)


Current approaches to spatial normalisation of brain images have made use of a target image to which each subject image is matched. However, in many cases the use of a single brain template, or a statistical one derived from multiple subjects of another population, does not adequately capture the structure present in a population of anatomies under investigation. In such cases this paper proposes that a better approach may be to seek a method of driving subjects in the group into registration with each other, rather than with an unrepresentative template. This paper explores the approach of extending registration concepts from multi-modality registration, specifically those deriving criteria from the joint probability distribution of image values, to the general case of describing the alignment of a population of images simultaneously. Geometric constraints forcing the convergence to an average geometric shape are discussed and results presented on synthetic images and clinical brain image data.


Mutual Information White Matter Lesion Spatial Normalisation Fronto Temporal Dementia Joint Probability Distribution 
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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • C. Studholme
    • 1
  1. 1.Dept. RadiologyUniversity of CaliforniaSan Francisco

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