Abstract
The genetic mechanisms that are involved in the differentiation of a wide spectrum of cell types as well as those affecting higher levels of biological organization remain largely unknown in mammals. In part, this is due to the lack of a ready source of experimentally useful, mutant genes for study. Mammalian genetics, instead, has had to content itself primarily with mutants fortuitously obtained without specific selection and which often have fairly gross phenotypes, without a defined molecular basis, such as coat color changes or behavior defects. On the other hand, there has evolved work on somatic cell genetics in culture that has enabled mutagenesis and selection of specific biochemical mutations to be realized at the cellular level, albeit without appreciable differentiation.
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Dewey, M.J., Mintz, B. (1980). Teratocarcinoma Cells as Agents for Producing Mutant Mice. In: McKinnell, R.G., DiBerardino, M.A., Blumenfeld, M., Bergad, R.D. (eds) Differentiation and Neoplasia. Results and Problems in Cell Differentiation, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38267-6_35
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DOI: https://doi.org/10.1007/978-3-540-38267-6_35
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