Abstract
Most carcinomas and sarcomas in man are metastatic neoplasms. On the other hand, most solid tumors in mice, whether spontaneous or experimentally induced, are nonmetastatic. In the absence of mouse metastatic tumors, experimental models for the study of tumor metastasis have been rather limited, hence, the limitations imposed on the study of the mechanisms controlling metastatic spread and progression. In fact, some very basic questions have not been fully investigated, e.g., the question of whether a population of tumor metastasis cells is a random representative of the population of the local growth or whether it is a selected subpopulation possessing cell surface properties which might determine the metastatic properties. Recent studies have indicated that metastatic cells may differ from the primary cell population in a number of properties, such as susceptibility to drugs (Trope 1975), affinity to different organs (Fidler and Nicolson 1976; Nicolson et al. 1976) and chromosome number (Rabotti 1959; Chu and Ulmgren 1961).
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© 1980 Springer-Verlag Berlin Heidelberg
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Gorelik, E., Fogel, M., Segal, S., Feldman, M. (1980). The Control of Tumor Metastasis. In: McKinnell, R.G., DiBerardino, M.A., Blumenfeld, M., Bergad, R.D. (eds) Differentiation and Neoplasia. Results and Problems in Cell Differentiation, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38267-6_30
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DOI: https://doi.org/10.1007/978-3-540-38267-6_30
Publisher Name: Springer, Berlin, Heidelberg
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