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Control of Genome Integrity in Terminally Differentiating and Postmitotic Aging Cells

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Differentiation and Neoplasia

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 11))

Abstract

During early morphogenesis, organ- or tissue-specific “stem” cell lines are established. Initially multipotent, the progeny become committed to the expression of an increasingly restricted number of specialized phenotypes. The process leading to acquisition by cells of specialized structures and/or functions is called cell differentiation. Implicit in such a process is the progressive loss of the potential for tissue metaplasia, i.e., the ability to be reprogramed and converted into another phenotype. A rare exception to this rule in vertebrates is the Wolffian lens regeneration in lentectomized newts where fully differentiated melanocytes from the dorsal iris dedifferentiate, proliferate and then redifferentiate into lens fiber cells (Yamada 1977).

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Authors and Affiliations

  1. Unit of Developmental Biology, Institute of Pharmacology, CHUV, 1011, Lausanne, Switzerland

    S. P. Modak

  2. Department of Zoology, University of Poona, Pune, 411007, India

    S. P. Modak

  3. Österreichische Akademie der Wissenschaften, Institut für Molekularbiologie, Salzburg, Austria

    C. Unger-Ullmann

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  1. S. P. Modak
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  2. C. Unger-Ullmann
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Editors and Affiliations

  1. Department of Genetics and Cell Biology, University of Minnesota, 250 Biological Sciences Center, St. Paul, MN, 55108, USA

    Robert G. McKinnell

  2. Department of Anatomy, Medical College of Pennsylvania, Philadelphia, PA, 19129, USA

    Marie A. DiBerardino

  3. Department of Genetics and Cell Biology, University of Minnesota, 250 Biological Sciences Center, St. Paul, MN, 55108, USA

    Martin Blumenfeld  & Robert D. Bergad  & 

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© 1980 Springer-Verlag Berlin Heidelberg

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Modak, S.P., Unger-Ullmann, C. (1980). Control of Genome Integrity in Terminally Differentiating and Postmitotic Aging Cells. In: McKinnell, R.G., DiBerardino, M.A., Blumenfeld, M., Bergad, R.D. (eds) Differentiation and Neoplasia. Results and Problems in Cell Differentiation, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38267-6_23

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  • DOI: https://doi.org/10.1007/978-3-540-38267-6_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-11561-9

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