Use of IgY Antibodies in Human and Veterinary Medicine



Celiac Disease Dental Caries Cystic Fibrosis Patient White Spot Syndrome Virus Experimental Dental Caries 
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  1. Ahmed N, Rice GE (2005) Strategies for revealing lower abundance proteins in two-dimensional protein maps. J Chromatogr B 815:39–50.CrossRefGoogle Scholar
  2. Almeida CM, Kanashiro MM, Rangel Filho FB, Mata MF, Kipnis TL, da Silva WD (1998) Development of snake antivenom antibodies in chickens and their purification from yolk. Vet Record 143:579–584.Google Scholar
  3. Arasteh N, Aminirissehei A-H, Yousif AN, Albright LJ, Durance TD (2004) Passive immunization of rainbow trout (Oncorhynchus mykiss) with chicken egg yolk immunoglobulins (IgY). Aquaculture 231:23–36.CrossRefGoogle Scholar
  4. Bilbao GN, Chacana PA, Mendiburu A, Rodríguez E, Blackhall JO, Terzolo HR (2006) Profilaxis de la diarrea neonatal de terneros de tambo mediante suplementación con inmunoglobulinas de yema de huevo (IgY). Rev Med Vet (Bs As) 84:135–139.Google Scholar
  5. Calzado EG, Marino EC, Chavez TS, Vazquez EL, Ochoa ZC, Schade R (2003) Extraction of a monospecific Coombs-reagent from chicken eggs. ALTEX 20:21–25.Google Scholar
  6. Carlander D (2002) Avian IgY antibody, in vitro and in vivo. Acta Universitatis Upsaliensis, Comprehensive summaries of uppsala dissertations from the faculty of medicine 1119, University of Uppsala, Sweden, pp 1–153.Google Scholar
  7. Carlander D, Stalberg J, Larsson A (1999) Chicken antibodies. A clinical chemistry perspective. Upps J Med Sc 104:179–190.CrossRefGoogle Scholar
  8. Carlander D, Kollberg H, Wejaker P-E, Larsson A (2000) Peroral immunotherapy with yolk antibodies for the prevention and treatment of enteric infections. Immunol Res 21:1–6.PubMedCrossRefGoogle Scholar
  9. Carlander D, Kollberg H, Larsson A (2002) Retention of specific yolk IgY in the human oral cavity. BioDrugs 16:433–437.PubMedCrossRefGoogle Scholar
  10. Casswall T (1999) Passive immunisation as therapy for gastrointestinal infections in children. Doctoral Thesis, Karolinska Institute, Stockholm, pp 1–80.Google Scholar
  11. Chacana PA, Terzolo HR, Calzado EG, Schade R (2004) Tecnologia IgYo applicaciones de los anticuerpos de yema de huevo de gallina. Rev Med Veterinaria 85:179–189.Google Scholar
  12. Chang HM, Ou-Yang RF, Chen YT, Chen CC (1999) Productivity and some properties of immunoglobulin specific against Streptococcus mutans serotype c in chicken egg yolk (IgY). J Agric Food Chem 47:61–66.PubMedCrossRefGoogle Scholar
  13. Cova L (2005) DNA-designed avian IgY antibodies: novel tools for research, diagnostics and therapy. J Clin Virol 34 Suppl 1:S70–S74.CrossRefGoogle Scholar
  14. Danielpour D, Roberts AB (1995) Specific and sensitive quantitation of transforming growth factor b3 by sandwich enzyme-linked immunosorbent assay. J Immun Methods 180:265–272.CrossRefGoogle Scholar
  15. De Ceuninck F, Pastoureau P, Agnellet S, Bonnet J, Vanhoutte PM (2001) Development of an enzyme-linked immunoassay for the quantification of YKL-40 (cartilage gp-39) in guinea pig serum using hen egg yolk antibodies. J Immunol Methods 252:153–161.PubMedCrossRefGoogle Scholar
  16. Erhard MH, Bergmann J, Renner M, Hofmann A, Heinritzi K (1996) Prophylactic effect of specific egg yolk antibodies in diarrhoea of weaned piglets caused by Escherichia coli K88 (F4). J Vet Med A 43:217–223.CrossRefGoogle Scholar
  17. Finlay WJJ, deVore NC, Dobrovolskaia EN, Goodyear CS, Slater JE (2005) Exploiting the avian immunoglobulin system to simplify the generation of recombinant antibodies to allergenic proteins. Clin Exp Allergy 35:1040–1048.PubMedCrossRefGoogle Scholar
  18. Gerl M, Steinert C, Quint M, Schade R, Günzler V (1996) Immunisation of chickens with the aminoterminal propeptide of bovine procollagen type III. ALTEX 13 Suppl 1:51–56.Google Scholar
  19. Gomez CM, Biamonte S, Barragan J, Babusci M, Garavano J, Guillen G, Schade R (2006) Production of chicken antibodies against botulinic toxin A. Adv Agric Sci 10:25–32.Google Scholar
  20. Hamada S, Kodoma Y (1996) Passive immunity for protection against mucosal infections and vaccination for dental caries. In: Kiyono H, Ogra PL, McGhee JR (eds) Mucosal vaccines. Academic Press, New York, pp 187–197.CrossRefGoogle Scholar
  21. Hatta H, Mabe K, Kim M, Yamamoto T, Guiterrez MA, Miyazaki T (1994) Prevention of fish disease using egg yolk antibody. In: Sim JS, Nakai S (eds) Egg uses and processing technologies. CAB International, Wallingford, UK, pp 241–249.Google Scholar
  22. Hatta H, Tsuda K, Ozeki M, Kim M, Yamamoto T, Otake S, Hirasawa M, Katz J, Childers NK, Michalek SM (1997) Passive immunization against dental plaque formation in humans: effect of a mouth rinse containing egg yolk antibodies (IgY) specific to Streptococcus mutans. Caries Res 31:268–274.PubMedCrossRefGoogle Scholar
  23. Hau J and Hendriksen CFM (2005) Refinement of polyclonal antibody production by combining oral immunization of chickens with harvest of antibodies from the egg yolk. ILAR 46:294–299.Google Scholar
  24. Hinerfeld D, Innamorati D, Pirro J, Tam SW (2004) Serum/plasma depletion with chicken immunoglobulin Y antibodies for proteomic analysis from multiple mammalian species. J Biomol Tech 15:184–190.PubMedGoogle Scholar
  25. Horie K, Horie N, Abdou AM, Yang JO, Yun SS, Chun HN, Park CK, Kim M, Hatta H (2004) Suppressive effect of functional drinking yogurt containing specific egg yolk immunoglobulin on Helicobacter pylori in humans. J Dairy Sci 87:4073–4079.PubMedCrossRefGoogle Scholar
  26. Huang L, Harvie G, Feitelson JS, Gramatikoff K, Herold DA, Allen DL, Amunngama R, Hagler RA, Pisano MR, Zhang W-W, Fang X (2005) Immunoaffinity separation of plasma proteins by IgY microbeads: Meeting the needs of proteomic sample preparation and analysis. Proteomics 5:3314–3328.PubMedCrossRefGoogle Scholar
  27. Karlsson M, Kollberg H, Larsson A (2004) Chicken IgY: utilizing the evolutionary advantage. World's Poultry Sci J 60:341–347.CrossRefGoogle Scholar
  28. Kim DK, Jang IK, Seo HC, Shin SO, Yang SY, Kim JW (2004) Shrimp protected from WSSV disease by treatment with egg yolk antibodies (IgY) against a truncated fusion protein derived from WSSV. Aquaculture 237:21–30.CrossRefGoogle Scholar
  29. Klemperer F (1893) Ueber natürliche Immunität und ihre Verwerthung für die Immuni-sierungstherapie. Arch Exp Pathol Pharmakol 31:356–382.CrossRefGoogle Scholar
  30. Kollberg H, Carlander D, Olesen H, Wejaker P-E, Johannesson M, Larsson A (2003) Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase I feasibility study. Pediatr Pulmonol 35:433–440.PubMedCrossRefGoogle Scholar
  31. Kovacs-Nolan J, Mine Y (2004) Passive immunization through avian egg antibodies. Food Biotechnol 18:39–62.CrossRefGoogle Scholar
  32. Kuroki M, Ohta M, Ikemori Y, Icatlo FC, Kobayashi C, Yokoyama H, Kodama Y (1997) Field evaluation of chicken egg yolk immunoglobulins specific for bovine rotavirus in neonatal calves. Arch Virol 142:843–851.PubMedCrossRefGoogle Scholar
  33. Larsson A, Karlsson-Parra A, Sjöquist J (1991) Use of chicken antibodies in enzyme immunoassays to avoid interference by rheumatoid factors. Clin Chem 37:411–414.PubMedGoogle Scholar
  34. Larsson A, Wejaker P-E, Forsberg P-O, Lindahl T (1992) Chicken antibodies: a tool to avoid interference by complement activation in ELISA. J Immunol Methods 156:79–83.PubMedCrossRefGoogle Scholar
  35. LeClaire RD, Hunt RE, Bavari S (2002) Protection against bacterial staphylococcal enterotoxin B by passive vaccination. Infect Immun 70:2278–2281.PubMedCrossRefGoogle Scholar
  36. Lee SB, Mine Y, Stevenson MW (2000) Effects of hen egg yolk immunoglobulin in passive protection of rainbow trout against Yersinia ruckeri. J Agric Food Chem 48:110–115.PubMedCrossRefGoogle Scholar
  37. Lee EN, Sunwoo HH, Menninen K, Sim JS (2002) In vitro studies of chicken egg yolk antibody (IgY) against Salmonella enteritidis and Salmonella typhimurium. Poultry Science 81:632–641.PubMedGoogle Scholar
  38. Leenars PPAM, Hendriksen CFM, de Leeuw WA, Carat F, Delahaut P, Fischer R, Halder M, Hanly WC, Hartinger J, Hau J, Lindblad EB, Nicklas W, Outschoorn IM, Stewart-Tull DES (1999) The production of polyclonal antibodies in laboratory animals. The report and recommendations of ECVAM workshop 35. ATLA 27:79–102.Google Scholar
  39. Lemley PV, Thalley BS, Stafford DC (1995) Prophylactic and therapeutic efficacy of an avian antitoxin in ricin intoxication. Therap Immunol 2:59–66.Google Scholar
  40. Lösch U, Schranner I, Wanke R, Jürgens L (1986) The chicken egg: an antibody source. J Vet Med B 33:609–619.Google Scholar
  41. Marquardt RR, Jin LZ, Jung-Woo K, Fang L, Frohlich AA, Baidoo SK (1999) Passive protective effect of egg-yolk antibodies against enterotoxigenic Escherichia coli K88+ infection in neonatal and early weaned piglets. FEMS Immunol Med Microbiol 23:283–88.PubMedCrossRefGoogle Scholar
  42. Mine Y, Kovacs-Nolan J (2002) Chicken egg yolk antibodies as therapeutics in enteric infectious disease: a review. J Med Food 5:159–169.PubMedCrossRefGoogle Scholar
  43. Nakamura N, Shuyama A, Hojyo S, Shimokawa M, Miyamoto K, Kawashima T, Aosasa M, Horiuchi H, Furusawa S, Matsuda H (2004) Establishment of a chicken monoclonal antibody panel against mammalian prion protein. J Vet Med Sci 66:807–814.PubMedCrossRefGoogle Scholar
  44. Narat M (2003) Production of antibodies in chickens. Food Technol Biotechnol 41:259–267.Google Scholar
  45. Nomura S, Suzuki H, Masaoka T, Kurabayashi K, Ishii H, Kitajima M, Nomoto K, Hibi T (2005) Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils. Helicobacter 10:43–52.PubMedCrossRefGoogle Scholar
  46. Otake S, Nishihara Y, Makimura M, Hatta H, Kim M. Yamamoto T, Hirasawa M (1991) Protection of rats against dental caries by passive immunization with hen-egg-yolk antibody (IgY). J Dent Res 70:162–166.PubMedGoogle Scholar
  47. Park KJ, Park DW, Kim CH, Han BK, Park TS, Han JY, Lillehoj HS, Kim J-K (2005) Development and characterization of a recombinant chicken single-chain Fv antibody detecting Eimeria acervulina sporozoite antigen. Biotechnol Letters 27:289–295.CrossRefGoogle Scholar
  48. Pichler H, Krska R, Szekacs A, Grasserbauer M (1998) An enzyme-immunoassay for the detection of the mycotoxin zearalenone by use of yolk antibodies. Fresenius J Analyt Chem 362:176–177.CrossRefGoogle Scholar
  49. Pokorova D, Franz J, Stepanek J (2000) The use of egg yolk immunoglobulin in the diagnostics of canine parvovirus infections. Veterinarni Medicina 45:49–54.Google Scholar
  50. Rosol TJ, Steinmeyer CL, McCauley LK, Merryman JI, Werkmeister JR, Gröne A, Weckman MT, Swayne DE, Capen CC (1993) Studies on chicken polyclonal anti-peptide antibodies specific for parathyroid hormone-related protein (1–36). Vet Immunol Immunopathol 35:321–337.PubMedCrossRefGoogle Scholar
  51. Sarker SA, Casswall TH, Juneja LR, Hoq E, Hossain I, Fuchs GJ, Hammarström L (2001) Randomized, placebo-controlled, clinical trial of hyperimmunized chicken egg yolk immunoglobulin in children with rotavirus diarrhea. J Ped Gastroenterol Nutr 32:9–25.CrossRefGoogle Scholar
  52. Schade R, Behn I, Erhard M, Hlinak A, Staak C (2000) Chicken egg yolk antibodies, production and application: IgY technology. Springer Lab Manuals, Berlin Heidelberg New York, pp 1–255.Google Scholar
  53. Schade R, Calzado EG, Sarmiento R, Chacana PA, Porankiewicz-Asplund J, Terzolo HR (2005) Chicken egg yolk antibodies (IgY-technology): A review of progress in production and use in research and human and veterinary medicine. ATLA 33:129–154.PubMedGoogle Scholar
  54. Schniering A, Schade R, Hiepe T (1996) Development of an IgY-based assay for the detection of Ascaris suum antigens. ALTEX 13 Suppl 1:62–65.Google Scholar
  55. Shimamoto C, Tokioka S, Hirata I, Tani H, Ohishi H, Katsu K (2002) Inhibition of Helicobacter pylori infection by orally administered yolk derived anti-Helicobacter pylori antibody. Hepatogastroenterology 49:709–714.PubMedGoogle Scholar
  56. Shin JH, Nam SW, Kim JT, Yoon JB, Bang WG, Roe IH (2003) Identification of immunodominant Helicobacter pylori proteins with reactivity to H. pylori-specific egg-yolk immunoglobulin. J Med Microbiol 52:217–222.PubMedCrossRefGoogle Scholar
  57. Smith DJ, King WF, Godiska R (2001) Passive transfer of immunoglobulin Y antibody to Streptococcus mutans glucan binding protein B can confer protection against experimental dental caries. Infect Immun 69:3135–3142.PubMedCrossRefGoogle Scholar
  58. Sunwoo HH, Sim JS (2004) IgY as ovo-nutraceuticals: Anti-gluten specific IgY enforced egg products for celiac disease. The 3rd international symposium on egg nutrition for health promotion. April 18–21, Banff, Alberta, Canada.Google Scholar
  59. Sunwoo HH, Lee EN, Menninen K, Suresh MR, Sim JS (2002) Growth inhibitory effect of chicken egg yolk antibody (IgY) on Escherichia coli 0157:H7. J Food Sci 67:1486–1494.CrossRefGoogle Scholar
  60. Suzuki H, Nomura S, Masaoka T, Goshima H, Kamata N, Kodama Y, Ishii H, Kitajima M, Nomoto K, Hibi T (2004) Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection. Aliment Pharmacol Ther 20 Suppl 1:185–192.Google Scholar
  61. Terzolo H, Chacana P, Vivas A, Greco C, Goya R, Schade R (2003) IgY technology in Argentina. ALTEX 20:202–203.Google Scholar
  62. Thalley BS, Carroll SB (1990) Rattlesnake and scorpion antivenoma from the egg yolks of immunized hens. Biotechnol 8:934–938.CrossRefGoogle Scholar
  63. Tsurushita N, Park M, Pakabunto K, Ong K, Avdalovic A, Fu H, Jia A, Vásquez M, Kumar S (2004) Humanization of a chicken anti-IL-12 monoclonal antibody. J Immunol Methods 295:9–19.PubMedCrossRefGoogle Scholar
  64. Wiedemann V, Linckh E, Kühlmann R, Schmidt P, Lösch U (1991) Chicken egg antibodies for prophylaxis and therapy of infectious intestinal disorders. V. In vivo studies on protective effects against Escherichia coli diarrhea in pigs. J Vet Med Series B 38:283–291.CrossRefGoogle Scholar
  65. Worledge KL, Godiska R, Barrett TA, Kink JA (2000) Oral administration of avian tumor necrosis factor antibodies effectively treats experimental colitis in rats. Digest Dis Sci 45:2298–2305.PubMedCrossRefGoogle Scholar
  66. Yolken RH, Leister F, Wee S-B, Miskuff R, Vonderfecht S (1988) Antibodies to rotaviruses in chicken's eggs: a potential source of antiviral immunoglobulins suitable for human consumption. Pediatrics 81:291–295.PubMedGoogle Scholar
  67. Yu QS, Wang GP, Wang W, Qin Y, Huang S (2004) Anti-King cobra egg yolk antibody from the egg yolks of immunized hens and its primary application. Chin J Microbiol Immunol 24:695–698.Google Scholar
  68. Zhou Z, Zhou R, Tang Z (2003) Effects of topical application of immunoglobulin yolk on mutans streptococci in dental plaque. Hua Xi Kou Quiang Yi Xue Za Zhi 21:295–297.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  1. 1.Institut für Pharmakologie und ToxikologieCharité-Universitätsmedizin BerlinBerlinGermany
  2. 2.Institut für Pharmakologie und ToxikologieCharité-Universitätsmedizin BerlinBerlinGermany
  3. 3.Instituto Nacional de Technolog´ia Agropecuaria (INTA)BalcarceArgentina

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