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Geneties of Schizophrenia and Bipolar Affective Disorder

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Vogel and Motulsky's Human Genetics

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Abstract

Schizophrenia and bipolar affective disorder (bipolar disorder, manic depression) are the paradigmatic illnesses of psychiatry. They profoundly affect thought, perception, emotion, and behavior, and their symptoms cause significant social and/ or occupational dysfunction. Schizophrenia and bipolar disorder have been recognized for several millennia, and the WHO (2001) ranks both among the top ten leading causes of the global burden of disease for the age group 15–44 years. Schizophrenia and bipolar disorder are illnesses with a largely unknown pathophys-iology and etiology. Evidence of a clear genetic contribution to the development of these disorders has led to important endeavors to discover the responsible genes. This chapter provides a concise and comprehensive review of the current state of genetic research into schizophrenia and bipolar disorder, and also of its limitations and possible future directions.

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  1. Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Str. 25, Bonn, 53127, Germany

    Markus M. Nöthen & Sven Cichon

  2. Department of Genetic Epidemiology in Psychiatry Central Institute of Mental Health Mannheim, University of Heidelberg J5, Mannheim, 68159, Germany

    Christine Schmael & Marcella Rietschel

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  1. Markus M. Nöthen
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  1. Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, Graz, 8010, Austria

    Michael R. Speicher

  2. Departments of Medicine (Division of Medical Genetics) and Genome Sciences, University of Washington School of Medicine, 1705 N.E. Pacific St., 355065, Seattle, WA, 98195-5065, USA

    Arno G. Motulsky (Professor Emeritus) (Professor Emeritus)

  3. Department of Genetic Medicine and Development, University of Geneva Medical School and University Hospitals of Geneva, 1 rue Michel-Servet, Geneva, 1211, Switzerland

    Stylianos E. Antonarakis

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Nöthen, M.M., Cichon, S., Schmael, C., Rietschel, M. (2010). Geneties of Schizophrenia and Bipolar Affective Disorder. In: Speicher, M.R., Motulsky, A.G., Antonarakis, S.E. (eds) Vogel and Motulsky's Human Genetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37654-5_32

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