Advertisement

Corneal Inlays (Synthetic Keratophakia)

  • M. Emilia Mulet
  • Jorge L Alió
  • Michael Knorz
Chapter

Abstract

  • The inlay implant technique is associated with specific complications; the most frequent are inlay displacements and intracorneal deposits.

  • Inlay implants correct low hyperopia with poorer results than the LASIK technique with increased ocular aberrations

  • Inlay explantations serve to eliminate complications.

  • Posterior retreatment of cases with explanted inlays is safe.

Keywords

Refractive Error Corneal Opacity Corneal Stroma Corneal Edema Irregular Astigmatism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Alió JL, Mulet ME, Zapata JL, Vidal MT, De Rojas V, Javaloy J (2004) Intracorneal inlay complicated by intrastromal epithelial opacification. Arch Ophthalmol 122:1441–446PubMedCrossRefGoogle Scholar
  2. 2.
    Alió JL, Shabayek MH (2006) Hyperopic LASIK following intracorneal hydrogel lens explantation. J Refract Surg 22:205–207PubMedGoogle Scholar
  3. 3.
    American Academy of Ophthalmology (1996) Epikeratoplasty: ophthalmic procedure assessment. Ophthalmology 103:983–991Google Scholar
  4. 4.
    Arbealaez MC, Perez-Santonja JJ, Ismail MM et al (1977) Automated lamellar keratoplasty (ALK) and laser in situ keratomileusis (LASIK). In: Serdarevic ON (ed) Refractive surgery: current techniques and management. Igaku-Shoin, New York, pp 131–150Google Scholar
  5. 5.
    Barraquer JL (1966) Modification of refraction by means of intracorneal inclusions. Int Ophthalmol Clin 6:53–78PubMedCrossRefGoogle Scholar
  6. 6.
    Barraquer JI, Gomez L (1987) Permalens hydrogel ultracorneal lenses for spherical ametropia. J Refract Surg 13:342–348Google Scholar
  7. 7.
    Beekhuis WH, McCarey BE, Rij GV, Waring GO III (1987) Complications of hydrogel intracorneal lenses in monkeys. Arch Ophthalmol 105:116–122PubMedGoogle Scholar
  8. 8.
    Binder PS, Deg JK, Zavala EY, Grossman KR (1982) Hydrogel keratophakia in non human primates. Curr Eye Res 1:535–542CrossRefGoogle Scholar
  9. 9.
    Binder PS, Zavala EY, Deg JK (1983) Hydrogel refractive keratoplasty. Lens renoval and exchanges. Cornea 2:119–125Google Scholar
  10. 10.
    Binder PS, Zavala EY, Deg JK (1987) Why do some epikeratoplasties fail? Arch Ophthalmol 105:63–69PubMedGoogle Scholar
  11. 11.
    Bleckmann H, Schnoy H, Keuch R (2004) Removal of epikeratophakia lenticules and implantation of intraocular lenses. Ophthalmologe 101,:285–289PubMedCrossRefGoogle Scholar
  12. 12.
    Cavanagh H, Sameh M, Petroll M, Jester J (2000) Specular microscopy confocal, and ultrasound biomicroscopy. Cornea 19:712–722PubMedCrossRefGoogle Scholar
  13. 13.
    Climenhaga H, McCarey BE (1986) Biocompatibility of polysulfone intracorneal lenses in the cat model. Invest Ophthalmol Vis Sci 27(Suppl):14Google Scholar
  14. 14.
    Cotran RS, Kumar V, Collins T (2006) Patologia structural y functional, 6th edn. McGraw-Hill Interamericana de Espa.a, Madrid, Spain, p 208–276Google Scholar
  15. 15.
    Dohlman CH, Refojo MF, Rose J (1967) Synthetic polymers in corneal surgery:glyceryl methacrylate. Arch Ophthalmol 177:52–58Google Scholar
  16. 16.
    Fine BS, Townsed WM, Zimmerman LE, Lashkari MH (1974) Preliminary lipoidal degeneration of the cornea. Am J Ophthalmol 78:12–23PubMedGoogle Scholar
  17. 17.
    Guell JL, Velasco F, Guerrero E, Gris O, Pujol J (2004) Confocal microscopy of cornea with an intracorneal lens for hyperopia. J Refract Surg 20.6:778–782PubMedGoogle Scholar
  18. 18.
    Helena MC, Baeveldt F, Kim WJ, Wilson SE (1997) Epithelial growth within the lamellar interface alter laser in situ keratomileusis (LASIK). Cornea 16:300–305PubMedGoogle Scholar
  19. 19.
    Ismail MM (1999) Management of post-Lasik overcorrections. In: Machat JJ, Slade SG, Probst LE (eds) The art of LASIK, 2nd edn. Slack, Thorofare, NJ, pp 451–457Google Scholar
  20. 20.
    Ismail MM (2002) Correction of hyperopia with intracorneal implants. J Cataract Refract Surg 28:527–530PubMedCrossRefGoogle Scholar
  21. 21.
    Kaminski SL, Biowski R, Koyuncu D, Lukas JR, Grabner G (2003) Ten year follow-up of epikeratophakia for the correction of high myopia. Ophthalmology 110:2147–2152PubMedCrossRefGoogle Scholar
  22. 22.
    Kaufman HE (1980) The correction of aphakia. Am J Ophthalmol 89:1–10PubMedGoogle Scholar
  23. 23.
    Keates RH, Martines E, Tennen DG, Reich C (1995) Small-diameter corneal inlay in presbyopic or pseudophakic patients. J Cataract Refract Surg 21:519–521PubMedGoogle Scholar
  24. 24.
    Lee WB, Mannis MJ (2003) Lasik after epikeratophakia. Cornea 22:382–384PubMedCrossRefGoogle Scholar
  25. 25.
    Martinez I, Mendicute J, Asensio AB, Madarieta I, Alava JI, Garagorri N, Aldazabal P (2005) Two different intracorneal inlay surgical technique in rabbit eyes. Arch Soc Esp Oftalmol 80:581–587Google Scholar
  26. 26.
    Masters B, Böhnke M (2001) Confocal microscopy of the human cornea in vivo. Int Ophthalmol 23:192–206CrossRefGoogle Scholar
  27. 27.
    Maurice DM (1969) Nutritional aspects of corneal grafts and prostheses. In: Rycrofts PV (ed) Corneo-plastic conference. Pergamon, Elmsford, N.Y., pp 197–207Google Scholar
  28. 28.
    McCarey BE (1986) Alloplastic refractive keratoplasty. In: Sanders D (ed) Refractive surgery: a text of radial keratotomy. Slack, Thorofare, N.J., p 530–548Google Scholar
  29. 29.
    McCarey BE, Andrews DM (1981) Refractive keratoplasty with intrastromal lenticular implants. Invest Ophthalmol Vis Sci 21:107–115PubMedGoogle Scholar
  30. 30.
    McCarey BE, McDonald MB, Rij GV, Salmeron B, Pettit DK, Knight PM (1989) Refractive results of hyperopic hydrogel intracorneal Lenses in primate eyes. Arch Ophthalmol 107:724–730PubMedGoogle Scholar
  31. 31.
    McCarey BE, Storie BR, Rij GV, Knight PM (1990) Refractive predictability of myopic hydrogel Intracorneal lenses in nonhuman primate eyes. Arch Ophthalmol 108:1310–1315PubMedGoogle Scholar
  32. 32.
    Mccarey BE, Schmidt FH (1990) Modeling glucose distribution in the cornea. Curr Eye Res 9:1025–1039PubMedCrossRefGoogle Scholar
  33. 33.
    McCarey BE, Waring GO III, Street DA (1987) Refractive keratoplasty in Monkeys using intracorneal lenses of various refractive indexes. Arch Ophthalmol 105:123–126PubMedGoogle Scholar
  34. 34.
    McDonald MB, McCarey BE, Storie B, Beuerman RW, Salmeron B, Rij GV, Knight PM (1993) Assessment of the long-term corneal response to hydrogel intrastromal lenses implanted in monkey eyes four to five years. 19:213–222Google Scholar
  35. 35.
    Miller KH, Green WR, Stark WJ et al (1980) Immunoprotein deposition in the Cornea Ophthalmology 87:944–950PubMedGoogle Scholar
  36. 36.
    Montes R, Rodriguez A, Aliò JL (2006) Femtosecond laser versus mechanical keratome LASIK for myopia. Ophthalmology 114:62–68CrossRefGoogle Scholar
  37. 37.
    Peyman GA, Beyer CF, Bezerra Y, Vincent JM, Arosemena A, Friedlander MH, Hoffman L, Kangeler J, Roussau D (2005) Photoablative inlay laser in situ keratomileusis (PAI-LASIK) in the rabbit model. J Cataract Refract Surg 389–397Google Scholar
  38. 38.
    Refojo MF (1968) Artificial membranes of corneal surgery. J Biomed Mater Res. 3:333–337CrossRefGoogle Scholar
  39. 39.
    Sendele DD, Abelson MB, Kenyon KR, Haninen CA (1983) Intracorneal lens implantation. Arch Ophthalmol 101:940–944PubMedGoogle Scholar
  40. 40.
    Shapiro LA, Farkas TG (1977) Lipid keratopathy following corneal hydrops. Arch Ophthalmol 95:456–458PubMedGoogle Scholar
  41. 41.
    Steirnet RF, Storie B, Smith P, Mcdonald MB, Rij GV, Bores LD et al (1996) Hydrogel intracorneal lenses in Aphakic eyes. Arch Ophthalmol 114:135–141Google Scholar
  42. 42.
    Stone W, Herbert E (1953) experimental study of plastic material as replacement for the cornea. Am J Ophthalmol 36:168–173PubMedGoogle Scholar
  43. 43.
    Wasty MA, McCarey BE, BeeKhuis WH (1985) Predicting refractive alterations with hydrogel keratophakia. Invest Ophthalmol Vis Sci 26:240–243Google Scholar
  44. 44.
    Werblin TP, Blaydes JE, Fryezkowski A et al (1982) Refractive corneal surgery: The use of implantable alloplastic lens material. Aust J Ophthalmol 11:325–331Google Scholar
  45. 45.
    Werblin TP, Patel AS, Barraquer JL (1992) Initial hydrogel intracorneal lens implants. Refract Corneal Surg 8:23–26PubMedGoogle Scholar
  46. 46.
    Xie RZ, Evans MD, Bojarski B, Hughes TC, Chan GY, Nguyen X, Wilkie JS, Mclean KM, Vannas A Sweeney DF (2006) Two-year preclinical testing of perfluoropolyether as a corneal inlay. Invest Ophthalmol Vis Sci 4:574–581CrossRefGoogle Scholar
  47. 47.
    Yamaguchy T, Koening SB, Hamano T et al (1984) Electron microscopic study of intracorneal hydrogel implants in primates. Ophthalmology 91:1170–1175Google Scholar
  48. 48.
    Zavala EY, Krrumeich J, Binder PS (1988) Clinical pathology of non-freeze lamellar refractive keratoplasty. Cornea 7:223–230PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • M. Emilia Mulet
    • 1
  • Jorge L Alió
    • 2
  • Michael Knorz
    • 3
  1. 1.Department of Ophthalmology Miguel Hernández University, Medical SchoolVissum CorporationAlicanteSpain
  2. 2.Miguel Hernández University, Medical SchoolVissum CorporationAlicanteSpain
  3. 3.FreeVis LASIK CenterMedical Faculty Mannheim of the University of Heidelberg Femto LASIK ProfessionalMannheimGermany

Personalised recommendations