Abstract
The idea that some event in the cell cycle may be important in making available to a daughter cell genetic information that is not readily available in the parent cell has been interpreted in various more specific ways according to the cell system being studied. On the basis of nuclear transplantation results we have suggested (review by Gurdon and Woodland, 1970) that nuclear swelling and chromosome condensation may be the important cell cycle events, rather than DNA synthesis or any other aspect of mitosis. In this article, we (A) outline the way in which the genetic reprogramming elicited by nuclear transplantation can in principle contribute to our understanding of the relationship between the cell cycle and the control of gene expression; (B) summarize the relevant results of nuclear transfer experiments so far performed, and (C) offer an interpretation of these and some other experiments, emphasizing the potential importance of cycles of nuclear swelling and chromosome condensation.
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© 1975 Springer-Verlag Berlin Heidelberg
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Gurdon, J.B. (1975). Nuclear Transplantation and the Cyclic Reprogramming of Gene Expression. In: Reinert, J., Holtzer, H. (eds) Cell Cycle and Cell Differentiation. Results and Problems in Cell Differentiation, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37390-2_7
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DOI: https://doi.org/10.1007/978-3-540-37390-2_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-21693-4
Online ISBN: 978-3-540-37390-2
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