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Histones, Differentiation, and the Cell Cycle

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Cell Cycle and Cell Differentiation

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 7))

Abstract

Albrecht Kossel discovered a new class of basic proteins known as histones among the nuclear proteins of goose erythrocytes in 1884 (155). In 1900 Traube reported the chemical synthesis and definitive identification of a white crystalline alkaloid called theophylline, which is one of the active ingredients of tea. According to Hnilica (122) theophylline was also discovered in Kossel’s laboratoy. We shall see by the end of this paper that it is possible to use theophylline in cells to determine one of the important functions of the histones and that it is quite intriguing that both of these apparently unrelated discoveries came from the same source.

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  1. Fels Research Institute, Temple University School of Medicine, Philadelphia, PA, USA

    Thaddeus W. Borun

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  1. Department of Anatomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Howard Holtzer

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Borun, T.W. (1975). Histones, Differentiation, and the Cell Cycle. In: Reinert, J., Holtzer, H. (eds) Cell Cycle and Cell Differentiation. Results and Problems in Cell Differentiation, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37390-2_12

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