Abstract
The aging process is one of the most challenging biological pathways to understand. Applications of model systems for aging have contributed significantly to the recent understanding of the aging process. Characteristics of the human Werner syndrome resemble those of normal aging in many ways. The premature aging disease Werner syndrome exhibits many symptoms of genomic instability, and the Werner syndrome protein (WRN) interacts with many proteins that participate in maintaining genomic integrity and repairing damaged DNA. This illustrates a strong correlation between aging and genomic instability. This review summarizes the biochemistry and the main DNA repair pathways of WRN and their impacts on genomic stability and aging.
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Cheng, WH., Opresko, P.L., Kobbe, C.v., Harrigan, J.A., Bohr, a.V.A. The human Werner Syndrome as a model system for aging. In: Model Systems in Aging. Topics in Current Genetics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37005-5_9
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DOI: https://doi.org/10.1007/978-3-540-37005-5_9
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-02490-3
Online ISBN: 978-3-540-37005-5
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